Omega-3 fatty acids inhibit oxidative stress in a rat model of liver regeneration

Abstract

PurposeLipid peroxidation and consequent reactive oxygen species in the setting of oxidative stress have crucial roles in liver regeneration, which may adversely affect the regeneration itself and lead to liver failure. The aim of the current study is to investigate whether omega-3 fatty acid supplementation inhibits oxidative stress in an experimental model of liver regeneration.MethodsForty rats were allocated to four groups. Rats in group A received a sham operation. Rats in group B were subjected to right portal vein ligation (RPVL) and saline infusion. Rats in groups C and D were subjected to RPVL and total parenteral nutrition (TPN) with an all-in-one admixture containing a soybean oil based lipid emulsion. Rats in group D were additionally supplemented with omega-3 fatty acid infusion. Oxidative stresses in the blood and liver were measured by glutathione, superoxide dismutase, catalase, glutathione peroxidase, malondialdehyde, and nitric oxide.ResultsOmega-3 supplementation to the TPN solution significantly corrected alterations in the blood and tissue concentrations of oxidants and anti-oxidants during regeneration (P < 0.05).ConclusionOmega-3 fatty acid supplementation to the TPN solution revealed promising results in removal of oxidative stress that emerges during liver regeneration.

Comparative Effects of Dietary Hemp and Poppy Seed Oil on Lipid Metabolism and the Antioxidant Status in Lean and Obese Zucker Rats

“…However, in the lean rats, dietary hemp seed oil was even able to favorably increase the hepatic ratio of GSH/GSSG, suggesting that PUFAs can have positive effects on the antioxidant status, if not disturbed by an obesogenic state. This seems to be in agreement with Firat et al [37], who observed an inhibition of oxidative stress in rat livers by omega-3 fatty acids.…”

Maresin 1, a Proresolving Lipid Mediator, Ameliorates Liver Ischemia-Reperfusion Injury and Stimulates Hepatocyte Proliferation in Sprague-Dawley Rats

“…The molecular mechanism may involve the increase of Nrf-2 in the nucleus and be correlated with cell proliferation. Firat et al reported the negative impact of oxidative stress via the production of ROS in cell proliferation, mainly due to the arrest of cell growth and activation of proteins that inhibit the cell cycle [54]. They found that the omega-3 parenteral administration to Wistar rats with right portal vein ligation, can reduce the levels of nitric oxide (NO) and ROS, with an increase in glutathione peroxidase and reduced glutathione (GSH), among other antioxidants' systems of defense, improving the system of regeneration in the contralateral lobe [54].…”

Comparison of olive leaf, olive oil, palm oil, and omega-3 oil in acute kidney injury induced by sepsis in rats

“…Fish oil contains a high concentration of omega-3 polyunsaturated fatty acids. Omega-3 fatty acids and their longer-chain downstream products, such as eicosapentaenoic acid (EPA), docosapentaenoic acid, and docosahexaenoic acid (DHA) have been reported to be beneficial in models of critical illness (Firat et al, 2017). The effects of omega-3 fatty acids include modulation of the immune response, inhibition of proinflammatory factors, and promotion of anti-inflammatory mediators.…”