Efficiency of herbal medicine Dai-kenchu-to on portal blood flow in rat models

Abstract

IntroductionTo clarify the influence of Dai-Kenchu-To (DKT) on portal blood flow (PBF), PBF was continuously measured with Doppler ultrasound.MethodsNormal liver rats were divided into a DKT 90 mg/kg, DKT 270 mg/kg administered group, and control, while cirrhotic liver rats were divided into a DKT-LC 90 mg/kg administered group and Control-LC. The PBF was measured after the administration of either DKT or water for 60 min by laser Doppler flowmetry system.ResultsThe PBF in the DKT 90 increased approximately 10 min after DKT was administrated, and elevated levels were maintained for approximately 10 min. A comparison of the increase in PBF by the calculating the area under the curve (AUC) revealed that flow was significantly higher in the DKT 90 compared to either the control or the DKT 270 (p < 0.05). The cirrhotic liver group showed stable PBF in both the DKT-LC and Control-LC. The AUC, revealed no significant difference between the DKT-LC and Control-LC.DiscussionDKT induced an increase in PBF in normal livers; however, its effects were insufficient to increase PBF in the cirrhotic livers. No increase in the portal blood flow in the cirrhotic liver rats was probably the result of the cirrhotic liver, which had fibrotic change, and, therefore, may not have had sufficient compliance to accept the increasing blood flow volume from the intestinal tract.ConclusionWe suggested DKT has the potential to protect the liver by increasing PBF when the liver has either normal or mild to moderate dysfunction.

Daikenchuto improved perioperative nutritional status of the patients with colorectal cancer: A prospective open-labeled randomized exploratory study

“…Basically, the active ingredient in TJ-100 most attributable to this effect is dried ginger rhizome [13]. Our previous study demonstrated an increase in the PBF after intragastric administration of TJ-100 in the normal liver rat model [14]. Theoretically, increase of the intestinal blood flow volume should increase the volume of PBF.…”

A Pilot Study Evaluating the Effectiveness and Safety of Daikenchuto (TJ-100) for the Treatment of Postoperative Abdominal Pain or Bloating in Patients Undergoing Hepatectomy: Study Protocol for a Randomized, Open, Controlled Trial

“…TJ-100 TSUMURA Daikenchuto Extract Granules consist of a dried extract of a mixture containing processed ginger, ginseng, zanthoxylum fruit, and maltose. It is clinically used to treat postoperative symptoms accompanied by abdominal pain and bloating sensation such as paralytic ileus and bowel move-ment disturbance, and the reported action mechanisms are enhanced gastrointestinal motility [1][2][3], increased intestinal blood flow [4,5] and anti-inflammatory effects [6,7]. Previous studies reported postoperative effects of DKT as shortening of the time to first defecation [8], first gas passage [9], and oral intake recovery [10] after abdominal surgery.…”