Imunossupressão com tacrolimus favorece a regeneração hepática induzida por hepatectomia ampla em ratos

Filho, Ozimo Gama; Toderke, Edimar Leandro; Baretta, Giórgio Alfredo Pedroso; Sakamoto, Daniele Giacometti; Agulham, Miguel Ângelo; Tâmbara, Elizabeth Milla; Matias, Jorge Eduardo Fouto

doi:10.1590/s0100-69912010000300010

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…It is known that some substances affect this process of regeneration. One study showed that the immunosuppressant tacrolimus has stimulatory effect on the process of liver regeneration after partial hepatectomy in rats 14 .…”

Section: Discussionmentioning

confidence: 99%

Proliferative effect of aqueous extract of Hyptis fructicosa on liver regeneration after partial hepatectomy in rats

Lima

Viana²,

Santana³

et al. 2012

Acta Cir. Bras.

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PURPOSE:To evaluate the effect of aqueous extract of Hyptis fructicosa on hepatic regeneration after partial hepatectomy in rats. METHODS:Sixteen rats were divided in two groups: C (Control Group) and HF (Whose rats received aqueous extract of Hyptis fructicosa during 4 days using the dose of 100 mg/kg/day). On the consecutive day of this treatment, the animals of both groups underwent hepatectomy of about 67% of liver. Twenty four hours later, they were sacrificed, and the remaining mass of liver was removed and prepared to be studied through the PCNA immunohistochemical technique. RESULTS:The liver regeneration index of HF group was 53.56 ± 18.91%, while in C group was 21.12 ± 8.29% (p=0.0003). CONCLUSION:These results show that the administration of aqueous extract of Hyptis fructicosa using the dose of 100mg/kg/day increased the hepatocyte proliferation in the group HF.Key words: Plants, Medicinal. Hepatectomy. Proliferating Cell Nuclear Antigen. Liver Regeneration. Hyptis. Rats. RESUMO OBJETIVO:Avaliar o efeito do extrato aquoso da Hyptis fructicosa sobre a regeneração hepática após hepatectomia parcial em ratos. MÉTODOS:Dezesseis ratos foram divididos em dois grupos: C (grupo controle) e HF (ratos que receberam o extrato aquoso da Hyptis fructicosa durante quatro dias na dose de 100mg/kg/dia). No dia consecutivo deste tratamento, os animais de ambos os grupos foram submetidos a hepatectomia de aproximadamente 67% do fígado. Vinte e quatro horas depois, eles foram sacrificados, e que a massa restante do fígado foi retirado e preparado para ser estudado através da técnica de imuno-histoquímica PCNA. RESULTADOS:O índice de regeneração hepática do grupo HF foi 53,56 ± 18,91%, enquanto no grupo C foi de 21,12 ± 8,29%(p=0,0003). CONCLUSÃO:Estes resultados mostram que a administração do extrato aquoso da Hyptis fructicosa na dose de 100mg/kg/dia aumentou a proliferação de hepatócitos no grupo HF.

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Section: Discussionmentioning

confidence: 99%

Proliferative effect of aqueous extract of Hyptis fructicosa on liver regeneration after partial hepatectomy in rats

Lima

Viana²,

Santana³

et al. 2012

Acta Cir. Bras.

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“…Moreira described that tacrolimus produces histological changes such as edema, inflammatory infiltration and atrophy in the pancreas, in the presence of acute pancreatitis induced in experimental models 4 . Gama Filho published on the effects of tacrolimus in liver regeneration after partial hepatectomy in rats 5 . Vizzotto Junior quantified the inflammatory response in a study on the influence of cisplatin administered preoperatively and postoperatively on the healing of colonic anastomoses in rats 6 .…”

Section: It Has the Effect Of Inhibiting The Signal Transduction Betwmentioning

confidence: 99%

“…The biochemical and histological effects of tacrolimus has been demonstrated in various organs in various animal studies4,5,9 . The evaluation of creatinine and urea in Wistar ratshas well established parameters under normal conditions.…”

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Analysis of the histology of the scar bladder and biochemical parameters of rats with a solitary kidney undergoing immunosuppression with tacrolimus

et al. 2014

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Aminodihydrophthalazinedione Sodium Transdermal Therapeutic System Specific Activity on an ExperimentalModel of Extensive Liver Resection

Кузнецова

Salomatina

Kuryleva

et al. 2023

Life

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Previously, the authors showed that the application of the aminodihydrophthalazinedione sodium (ADPS) immunomodulator transdermal therapeutic system (TTS) to laboratory animals provides bioavailability analogous to the intramuscular administration of this drug at the same dose. At the same time, its maximum blood concentration is significantly reduced, and the retention time of the drug in the body is increased more than 10-fold, which can contribute to prolonging the drug effect. The aim of the work was to identify a possible positive effect of the transdermal administration of the ADPS immunomodulator on reparative liver regeneration on an experimental model of extensive liver resection (ELR). It has been shown that at a period of 48 h after ELR, the percutaneous administration of the immunomodulator has a pronounced stimulating effect on the mitotic activity of rat liver cells; by 72 h after ELR, an accelerated rate of recovery of hepatic homeostasis in the body was observed in laboratory animals in groups with the application of the ADPS TTS versus the control group.

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Imunossupressão com tacrolimus favorece a regeneração hepática induzida por hepatectomia ampla em ratos

Abstract: Tacrolimus-based immunossuppression has stimulatory effect on liver regeneration process induced by 70% hepatectomy in adult Wistar rats.

Cited by 3 publications

References 19 publications

Proliferative effect of aqueous extract of Hyptis fructicosa on liver regeneration after partial hepatectomy in rats

Proliferative effect of aqueous extract of Hyptis fructicosa on liver regeneration after partial hepatectomy in rats

Analysis of the histology of the scar bladder and biochemical parameters of rats with a solitary kidney undergoing immunosuppression with tacrolimus

Aminodihydrophthalazinedione Sodium Transdermal Therapeutic System Specific Activity on an ExperimentalModel of Extensive Liver Resection

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