Interaction study of moxifloxacin with Cu(II) ion using square-wave voltammetry and its application in the determination in tablets

Abstract

This work presents an electroanalytical method for the determination of moxifloxacin (MOXI) in tablets by its interaction with Cu(II) ion and subsequent electrochemical reduction at hanging mercury drop electrode (HMDE). A well-defined reduction peak at -0.21 V vs. Ag/AgCl in Phosphate buffer 0.04 mol L-1 pH 8.0 was observed for the complex reduction MOXI-Cu(II), using square-wave voltammetry (SWV). Using a 10 s of accumulation time at -0.40 V was found a limit detection of 3.60x10-8 mol l-1. The obtained results have shown good agreement with those obtained by spectrophotometric method.

Synthesis of moxifloxacin–Au (III) and Ag (I) metal complexes and their biological activities

“…The solid residues above 530 and 500°C were identified as Au and Ag metal oxides, respectively. In all the complexes, the final products are metal oxides (Chawla et al 2012;Trindade et al 2006). The molar conductance of complexes in DMF (~10-3 M) was determined at 27 + 2°C using systronic 303 reading conductivity bridge for Au(III) and Ag (I) complexes of moxifloxacin.…”

Synthesis, Characterization, Spectrofluorometric and Antibacterial Activity Studies of Moxifloxacin- Zirconium Complex

“…The methods employed in the literature include high-Performance Liquid Chromatography (20,21) ; square-wave voltammetry by interaction of MOX with Cu(II) (6) ; potentiometric and UV spectrophotometric measurements through complex formation with gadolinium(III) ion (22) . Recently, MOX-copper complexes were synthesized, characterized and screened for anti-proliferative and apoptosis-inducing activity against multiple human breast cancer cell lines (23) .…”

“…The 1 H-NMR spectra were recorded on a JEOL 500 MHz spectrometer using DMSO-d 6 as a solvent and TMS as internal standard. Mass spectra (MS) were taken on an AEIMS 30 Mass spectrometer at 70eV.…”

“…It is available for oral and parenteral administration. IV formulation of MOX will now allow treatment of very ill hospitalized patients with respiratory or skin infections (3,5,6) .…”

Application of Electrochemical Methods for Analysis of Fluoroquinolones Antibacterial Agents and Fluoroquinolones-DNA Interactions

“…An electroanalytical method for the determination of moxifloxacin in tablets by its interaction with Cu(II) ion and subsequent electrochemical reduction at hanging mercury drop electrode has been developed [56]. A well-defined reduction peak in phosphate buffer was observed using accumulation for the complex moxifloxacin-Cu(II), using square-wave voltammetry.…”