Preparação e caracterização do complexo de inclusão do óleo essencial de Croton zehntneri com &amp;#946;-ciclodextrina

Aguiar, Ulisses Nogueira de; Lima, Sidney Gonçalo de; Rocha, Márcio dos Santos; Freitas, Rivelilson Mendes de; Oliveira, Antonio Thomaz de; Silva, Raiane M.; Moura, Lara C. B.; Almeida, Lorena T. G. de

doi:10.1590/s0100-40422014000100010

Cited by 28 publications

(18 citation statements)

References 19 publications

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“…For the Differential Scanning Calorimetry (DSC) analysis, a sample of approximately 5-10 mg was put into a hermetically-closed aluminum crucible and analyzed with a calorimeter, model DSC-60 (Shimadzu), under a nitrogen atmosphere at a flow rate of 50•mL −1 and a heating ratio of 10 • C•min −1 in the temperature range 25-300 • C. Mass losses and enthalpy changes were estimated using the TA 60w program (Shimadzu) as described by Aguiar et al [60].…”

Section: Physicochemical Characterization Of Inclusion Complexesmentioning

confidence: 99%

Development and Evaluation of Antimicrobial and Modulatory Activity of Inclusion Complex of Euterpe oleracea Mart Oil and β-Cyclodextrin or HP-β-Cyclodextrin

Magalhães

Macedo

Pacheco

et al. 2020

IJMS

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The development of inclusion complexes is used to encapsulate nonpolar compounds and improve their physicochemical characteristics. This study aims to develop complexes made up of Euterpe oleracea Mart oil (EOO) and β-cyclodextrin (β-CD) or hydroxypropyl-β-cyclodextrin (HP-β-CD) by either kneading (KND) or slurry (SL). Complexes were analyzed by molecular modeling, Fourier-transform infrared spectroscopy, scanning electron microscopy, powder X-ray diffraction, thermogravimetry analysis and differential scanning calorimetry. The antibacterial activity was expressed as Minimum Inhibitory Concentration (MIC), and the antibiotic resistance modulatory activity as subinhibitory concentration (MIC/8) against Escherichia coli, Streptomyces aureus, Pseudomonas aeruginosa and Enterococcus faecalis. Inclusion complexes with β-CD and HP-β-CD were confirmed, and efficiency was proven by an interaction energy between oleic acid and β-CD of −41.28 ± 0.57 kJ/mol. MIC values revealed higher antibacterial activity of complexes compared to the isolated oil. The modulatory response of EOO and EOO-β-CD prepared by KND as well as of EOO-β-CD and EOO-HP-β-CD prepared by SL showed a synergistic effect with ampicillin against E. coli, whereas it was not significant with the other drugs tested, maintaining the biological response of antibiotics. The antimicrobial response exhibited by the complexes is of great significance because it subsidizes studies for the development of new pharmaceutical forms.

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Section: Physicochemical Characterization Of Inclusion Complexesmentioning

confidence: 99%

Development and Evaluation of Antimicrobial and Modulatory Activity of Inclusion Complex of Euterpe oleracea Mart Oil and β-Cyclodextrin or HP-β-Cyclodextrin

Magalhães

Macedo

Pacheco

et al. 2020

IJMS

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“…The molecular mass of the estragole (148 Da) is compatible with the size of β-CD that is capable of complexing substance in the molecular mass range of 100 to 400 Da. 8,29 The extraction of the inclusion complex enabled to determine that only the estragole, the major constituent of CZEO was encapsulated. Thus, for the analyses of ATR-FTIR and Raman, ES will be considered the only constituent of CZEO.…”

Section: Figure 3 Chromatogram Of C Zehntneri Essential Oil Extractmentioning

confidence: 99%

“…The leaves of C. zehntneri are used to prepare teas, which are employed by local people to treat nervous disorders, anxiety, seizures, insomnia and to relieve gastrointestinal disturbances. [5][6][7][8][9] Estragole…”

Section: Introductionmentioning

confidence: 99%

Characterization of Inclusion Complex of Croton zehntneri Essential Oil and β-Cyclodextrin Prepared by Spray Drying and Freeze Drying

Fonseca

Rocha²,

Brito³

et al. 2019

Rev. Virtual Quim.

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Caracterização do Complexo de Inclusão do Óleo Essencial de Croton zehntneri e β-Ciclodextrina Preparados Através da Secagem por Atomização e Liofilização Resumo: Croton zehntneri (CZ) é uma espécie aromática da família Euphorbiaceae, nativa do Nordeste do Brasil, rica em óleo essencial (CZEO) com propriedades antioxidante, vasorelaxante, bactericida e fungicida. Apesar dos inúmeros potenciais biológicos e farmacológicos, óleos essenciais são instáveis e possuem limitada solubilidade em água, características que podem ser melhoradas pela formação de complexos de inclusão com ciclodextrinas (CDs). No presente estudo, o complexo de inclusão de CZEO e β-CD foi preparado por co-precipitação acoplada à liofilização e secagem por atomização. O complexo de inclusão foi caracterizado por espectroscopia vibracional (espectroscopia Raman e FT-IR) e a eficiência de complexação determinada por cromatografia gasosa acoplada à espectrometria de massa (CG-EM). Foi observado que a co-precipitação acoplada à liofilização possibilitou uma maior eficiência de complexação quando comparada ao spray drying. A espectroscopia Raman confirma a formação do complexo de inclusão entre CZEO e β-CD por ambos os métodos de preparação.

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“…Cyclodextrins (CD's) are cyclic oligosaccharides consisting of glucose units linked by α-(1,4) glycosidic bonds derived from the enzymatic degradation of starch by certain bacteria, and they are chemically and physically stable molecules [95,97]. The most common natural CDs have six, seven, and eight d-glucopyranose units and are named α, β, and γ cyclodextrin, respectively, and they differ from each other by virtue of ring size and solubility [98].…”

Section: Cyclodextrinsmentioning

confidence: 99%

“…The most common natural CDs have six, seven, and eight d-glucopyranose units and are named α, β, and γ cyclodextrin, respectively, and they differ from each other by virtue of ring size and solubility [98]. While the central cavity of CDs has a hydrophobic character, the surrounding walls are hydrophilic, and this feature allows CDs to form capsules, acting as a host for lipophilic compounds in their cavities and forming inclusion complexes [97,[99][100][101].…”

Section: Cyclodextrinsmentioning

confidence: 99%

β-Cyclodextrins as Encapsulating Agents of Essential Oils

Capelezzo¹,

Mohr²,

Dalcanton³

et al. 2018

Cyclodextrin - A Versatile Ingredient

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Many scientific studies have made advances in the ability to encapsulate natural extracts by cyclodextrins. These studies have addressed the physical and chemical conditions of the encapsulation reactions, employed several types of essential oils and characterized the microcapsules as to their ability to release encapsulated active principles. The essential oils studies with cyclodextrin encapsulation processes have been highly varied. However, the most studied are the essential oils with antimicrobial and antioxidant capacities. The essential antimicrobial and antioxidant oils are easily degraded. In the presence of oxygen, they are oxidized, and at low temperatures, they are volatilized and decomposed. Thus, cyclodextrins are coatings capable of protecting these essential oils from environmental conditions and agents capable of promoting oil degradation, in addition to controlling their release. In this chapter of the book, we review scientific papers that examine the encapsulation of antimicrobial essential oils and antioxidant essential oils with β-cyclodextrins.

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Preparação e caracterização do complexo de inclusão do óleo essencial de Croton zehntneri com β-ciclodextrina

Cited by 28 publications

References 19 publications

Development and Evaluation of Antimicrobial and Modulatory Activity of Inclusion Complex of Euterpe oleracea Mart Oil and β-Cyclodextrin or HP-β-Cyclodextrin

Development and Evaluation of Antimicrobial and Modulatory Activity of Inclusion Complex of Euterpe oleracea Mart Oil and β-Cyclodextrin or HP-β-Cyclodextrin

Characterization of Inclusion Complex of Croton zehntneri Essential Oil and β-Cyclodextrin Prepared by Spray Drying and Freeze Drying

β-Cyclodextrins as Encapsulating Agents of Essential Oils

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