Atividade de extratos de Arrabidaea chica (Humb. &amp; Bonpl.) Verlot obtidos por processos biotecnológicos sobre a proliferação de fibroblastos e células tumorais humanas

Taffarello, Denise; Jorge, Michelle Pedroza; Sousa, Ilza Maria de Oliveira; Duarte, Marta Cristina Teixeira; Figueira, Glyn Mara; Queiroz, Núbia de Cássia Almeida; Rodrigues, Rodney Alexandre Ferreira; Carvalho, João Ernesto de; Goes, Ana Lucia Tasca Ruiz; Foglio, Mary Ann; Riveros, José M.; Eberlin, Marcos N.; Cabral, Elaine C.

doi:10.1590/s0100-40422013000300014

Cited by 13 publications

(7 citation statements)

References 9 publications

(9 reference statements)

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“…The choice for the positive ion mode in the analyses was based on the cationic characteristic of the 3deoxyanthocyanidins (1-4). The ions m/z 285, 299, 301 and 315 were identified in the sample of A. chica in previous analyses by ESI-(+)-MS (Schiozer et al 2012, Mafiolletti et al, 2013, Taffarello et al, 2013. In addition to these four substances, Cabral (2010) detected the presence of other anthocyanidins though the peaks of m/z 271, 287, 303, 317 and 319 through studies using ESI(+) MS/MS.…”

Section: Resultsmentioning

confidence: 81%

“…Arrabidaea chica is characterized by the occurrence of the class of deoxyanthocyanidins, which are responsible for conferring the reddish color characteristic of its extracts (Schioz et al, 2012). Through electrospray ionization mass spectrometry (ESI-MS), some authors have identified and characterized four chemical markers belonging to the 3deoxyanthocyanidin class: 6,7-dihydroxy-5,4'-dimethoxyflavylium (carajurine) (I), 6,7,4'-trihydroxy-5-methoxyflavylium (carajurone) (II), 6,7,3'-trihydroxy-5,4'-dimethoxyflavylium (III) and 6,7,3',4'-tetrahydroxy-5-methoxyflavylium (IV) (Zorn et al, 2001;Schiozer et al, 2012;Mafiolletti et al, 2013;Taffarello et al, 2013). Ambient ionization is an area of mass spectrometry that has emerged quickly in several methods, all aiming at direct and rapid sampling of analytes in complex samples with the minimum of previous treatment in their ambient state (Liu et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Mass spectrometry with paper spray ionization in analysis of the Arrabidaea chica leaf tea

Andrade

Souza

Gomes

et al. 2021

RSD

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The species Arrabidaea chica (Humb. & Bonpl.) B. Verl. (Bignoniaceae) is a plant native to tropical forests, popularly known as pariri or crajiru, and it is widely used in folk medicine to treat inflammatory diseases, anemias, skin diseases and to assist in the treatment of leukemia. Because of the widespread use of the plant, concern with its quality and effectiveness is fundamental. This study demonstrates the application of mass spectrometry with ionization by paper spray (PS-MS) as a chemical characterization method to evaluate the presence of the active principles in teas prepared by infusion from commercial samples of the medicinal plant Arrabidaea chica by infusion. The analyses of the samples were performed in two periods: 24 hours and 15 days after the preparation of the teas. Compounds referring to the class of substances 3-deoxythocyanidins were detected without any pre-treatment of the sample or chromatographic separation to provide valuable information for the evaluation and quality control of this product. Significant changes in the m/z signals of greater intensity, referring to the class of 3-deoxythocyanidins, were observed in the mass spectra, and multivariate analysis corroborated the degradation of this class of substances with time, resulting in a probable loss of the quality and effectiveness of the tea.

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Section: Resultsmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Mass spectrometry with paper spray ionization in analysis of the Arrabidaea chica leaf tea

Andrade

Souza

Gomes

et al. 2021

RSD

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“…The authors [45] employed in vitro anticancer activity models to evaluate the influence of the variation in the relative proportion of anthocyanidins in the methanolic extracts of A. chica leaves that were collected over 13 months and prepared with and without enzymatic treatments on a panel of nine human tumor cell lines, MCF-7 (breast), NCI-ADR/RES (ovary with multiple resistance phenotypes), UACC-62 (melanoma), NCI-H460 (lung), PC-3 (prostate), HT29 (colon), OVCAR-03 (ovary), 786-0 (kidney), and K562 (leukemia), while the antioxidant activity was evaluated via the DPPH test. The raw extract, which was not treated with xylanases, stimulated the growth of fibroblasts of the 3T3 lineage in concentrations of 0.25, 2.5, and 25 µg/mL between January and June.…”

Section: Main Chemical Composition Of a Chicamentioning

confidence: 99%

A Review of the Phytochemistry and Pharmacological Properties of the Genus Arrabidaea

et al. 2022

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The genus Arrabidaea, consisting of ~170 species, belongs to the family Bignoniaceae, distributed around the Neotropics and temperate zone. The center of diversity of the family is in Brazil, where 56 genera and about 340 species exist. Most species of the genus Arrabidaea are traditionally utilized as diuretics and antiseptics, as well as for treating intestinal colic, diarrhea, kidney stones, rheumatoid arthritis, wounds, and enterocolitis. The genus is chemically diverse with different substance classes; most of them are triterpenes, phenolic acids, and flavonoids, and they exhibit valuable pharmacological properties, such as antitumor, antioxidant, leishmanicidal, trypanocidal, anti-inflammatory, and healing properties. This review presents information on the chemical constituents isolated from seven Arrabidaea species, and the pharmacological activities of the extracts, fractions and pure substances isolated since 1994, obtained from electronic databases. The various constituents present in the different species of this genus demonstrate a wide pharmacological potential for the development of new therapeutic agents, however its potential has been underestimated.

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“…& Bonpl.) B. Verlt está relacionada à presença das antocianinas (15,16) , informação essa corroborada por Jorge (2013) que afirma que a atividade cicatrizante da espécie vegetal está relacionada principalmente com as antocianinas, com pequena participação das agliconas, sendo que a carajurina apresenta um efeito estimulante sobre a proliferação celular (17) . O que comprova a atividade cicatrizante da A. chica, já que estudos comprovam que a mesma é fonte de antocianinas, flavonoides e taninos (18,19,20,21,22,2) .…”

Section: Segundo Taffarello (2008) E Taffarello Et Al (2013) a Atividade Cicatrizante Daunclassified

“…(17) Avaliar a capacidade cicatrizante dos extratos em modelo experimental de úlcera dérmica em ratos diabéticos. Taffarello D et al (16) Avaliar a influência do processo de fermentação enzimática de folhas de Arrabidaea chica (Humb. & Bonpl.)…”

unclassified

Propriedade Cicatrizante da Espécie Arrabidaea chica (HUMB. BONPL.) B. VERLT.: Uma Revisão Integrativa.

Silva¹,

Brabo²,

Lima³

et al. 2021

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Atividade de extratos de Arrabidaea chica (Humb. & Bonpl.) Verlot obtidos por processos biotecnológicos sobre a proliferação de fibroblastos e células tumorais humanas

Cited by 13 publications

References 9 publications

Mass spectrometry with paper spray ionization in analysis of the Arrabidaea chica leaf tea

Mass spectrometry with paper spray ionization in analysis of the Arrabidaea chica leaf tea

A Review of the Phytochemistry and Pharmacological Properties of the Genus Arrabidaea

Propriedade Cicatrizante da Espécie Arrabidaea chica (HUMB. BONPL.) B. VERLT.: Uma Revisão Integrativa.

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