Constituintes químicos das folhas de Riedeliella graciliflora Harms (Leguminosae)

Miranda, Mayker Lázaro Dantas; Souza, Alex Fonseca; Rodrigues, Edilene Delphino; Garcez, Fernanda Rodrigues; Garcez, Walmir Silva; Abot, Alfredo Raúl

doi:10.1590/s0100-40422012000700005

Cited by 12 publications

(11 citation statements)

References 8 publications

(7 reference statements)

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“…The chromatographic fractionation of leaf and twig extracts of P. nuda led to the isolation of 19 compounds: pomolic acid ( 1 ), spinosic acid ( 2 ), sitosterol ( 3 ), stigmasterol ( 4 ), campesterol ( 5 ), phytol ( 6 ), β -sitosterol-3- O -β- d -glucoside ( 7 ), β -stigmasterol-3- O - β - d -glucoside ( 8 ), cinchonain Ia ( 9 ), cinchonain Ib ( 10 ), N , N , N -trimethyltryptamine ( 11 ), lyaloside ( 12 ), lawsofructose ( 13 ), roseoside ( 14 ), strictosamide ( 15 ), scopoletin ( 16 ), rotungenic acid ( 17 ), strictosidine ( 18 ), and 5 α-carboxystrictosidine ( 19 ) (Figure 1). Substance identification was based on spectral analysis and data comparison with values described in the literature [21,22,23,24,25,26,27,28,29,30,31,32,33,34]. This is the first report of alkaloid ( 11 ) isolation from a natural product, as well as the isolation of the iridoid ( 14 ) and the flavonolignans ( 9 ) and ( 10 ) from the genus Psychotria .…”

Section: Resultsmentioning

confidence: 98%

Antimycobacterial and Nitric Oxide Production Inhibitory Activities of Triterpenes and Alkaloids from Psychotria nuda (Cham. & Schltdl.) Wawra

et al. 2019

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A phytochemical study of leaves and twigs of Psychotria nuda resulted in 19 compounds, including five indole alkaloids, N,N,N-trimethyltryptamine, lyaloside, strictosamide, strictosidine, and 5α-carboxystrictosidine; two flavonolignans, cinchonain Ia and cinchonain Ib; an iridoid, roseoside; a sugar, lawsofructose; a coumarin, scopoletin; a diterpene, phytol; three triterpenes, pomolic acid, spinosic acid, and rotungenic acid; and five steroids, sitosterol, stigmasterol, campesterol, β-sitosterol-3-O-β-d-glucoside, and β-stigmasterol-3-O-β-d-glucoside. Some compounds were evaluated for their in vitro activity against Mycobacterium tuberculosis and their ability to inhibit NO production by macrophages stimulated by lipopolysaccharide (LPS). The compounds pomolic acid, spinosic acid, strictosidine, and 5α-carboxystrictosidine displayed antimycobacterial activity with minimum inhibitory concentrations ranging from 7.1 to 19.2 µg/mL. These compounds showed promising inhibitory activity against NO production (IC50 3.22 to 25.5 μg/mL). 5α-carboxystrictosidine did not show cytotoxicity against macrophages RAW264.7 up to a concentration of 100 µg/mL. With the exception of strictosamide, this is the first report of the occurrence of these substances in P. nuda.

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Section: Resultsmentioning

confidence: 98%

Antimycobacterial and Nitric Oxide Production Inhibitory Activities of Triterpenes and Alkaloids from Psychotria nuda (Cham. & Schltdl.) Wawra

et al. 2019

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“…O cálculo do índice de deficiência de hidrogênio mostrou que a molécula apresenta seis insaturações, sendo cinco ciclos e uma ligação dupla evidenciada pelo RMN de 13 C através dos si ais a δ C 150,4 (C) e δ C 109,6 (CH 2 ). Um átomo de carbono o ige ado foi o servado a δ C 79,0 e a carboxila e δ C 181,2 (C=O).…”

Section: Resultsunclassified

“…A fração ECFH-10 (160,0 mg) foi submetida à cromatografia em coluna de gel de sílica 200-400 mesh (15,0 g; 3,0 X 40,0 cm) utilizando como solvente AcOEt:MeOH em ordem crescente de polaridade, levando ao isolamento do composto composto 9 (12,0 mg; 0:100). No espectro de RMN de 13 C foram listados trinta sinais que com o auxílio do DEPT 135 foram determinados como sendo: seis metilas, onze metilenos, seis metinos, seis carbonos não hidrogenados além de uma carboxila.…”

Section: Extração E Isolamento Dos Constituintes Químicosunclassified

“…Os triterpenos 3-oxo-β-amirina (3), ácido ursólico (4), β-amirina (5), lupeol (6) e esqualeno (7) foram identificados, a partir das análises dos espectros de RMN 1 H e 13 C e comparação com os dados espectrais já existentes na literatura. [9][10][11][12][13] As substâncias 8, 9 e 10 foram identificadas, a partir das análises dos espectros de RMN 1 H e 13 C e comparação com amostras autênticas, como sendo o peróxido de ergosterol (8), 14,15 cafeato de etila 9…”

Section: (Figura 3)unclassified

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Triterpenes and Other Constituents from Fruits of Enterolobium contortisiliquum (Vell.) Morong (Fabaceae)

Miranda¹,

Garcez²,

Garcez³

2015

Revista Virtual De Química

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From the fruits of specimen of Enterolobium contortisiliquum Fabaceae, ten known compounds were isolated, namely seven triterpenes, maslinic acid (1), betulinic acid (2), 3-oxo-β-amyrin (3), ursolic acid (4 , β-amyrin (5), lupeol (6) and squalene (7); one steroid, ergosterol peroxide (8); one caffeic acid derivative, ethyl caffeate (9) and the ficaprenol-12 (10). This is the first reported occurrence of triterpenes 1-4 and 7, steroid 8 and ficaprenol-12 in the genus Enterolobium. The structures of the isolated compounds were determined on the basis of their spectral data.

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“…58 Estes compostos possuem fórmulas estruturais incomuns, que permanecem com alguns desafios, incluindo a configuração dos centros estereogênicos e a biossíntese. 59 Ésteres de ácido salicílico com cadeias alquílicas de até seis carbonos são descritos como componentes de óleos essenciais, no entanto ésteres de cadeias maiores, tais como salicilato de tridecila e salicilato de 2-butiloctila são considerados tóxicos, podendo levar a danos nos rins e fígado. 60 Assim, a toxicidade das folhas de R. graciliflora para ruminantes pode estar relacionada à presença do salicilato de pentacosanila.…”

Section: Figura 9 Estruturas Químicas Das Substâncias 189-203unclassified

The Chemical Diversity from the Vegetation of Mato Grosso do Sul and its Relevance as a Source of Bioactive Molecules

Garcez¹,

Garcez²,

Yoshida³

et al. 2016

Revista Virtual De Química

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Plant species that occur in the major biomes of Mato Grosso do Sul state (Pantanal and Cerrado) have been chemically investigated by the research group on Natural Products Chemistry (PRONABio) at the Institute of Chemistry of the Federal University of Mato Grosso do Sul, Brazil. Extracts from approximately 120 species have been evaluated for their biological activities and many of them have been chemically studied. Several of these works were inspired by the medicinal use of these plants by the local population. The studies also involved investigation of plants with implications in one of the main economic activities of Mato Grosso do Sul, namely livestock-including investigation of toxic species for cattle and with acaricidal activity. Dengue, one of the major public health problems in Brazil, was also the subject of chemical investigation of active species against its vector, the mosquito Aedes aegypti. In this context, some of the results obtained from studies performed with members from the families Apocynaceae, Combretaceae, Cucurbitaceae, Erythroxylaceae, Fabaceae, Lamiaceae, Lauraceae, Malpighiaceae, Meliaceae and Rubiaceae, among others, are highlighted in the present article. Promising results were obtained for extracts, fractions and secondary metabolites isolated from members of these families with cytotoxic, genotoxic, recombinogenic, antimicrobial, and leishmanicidal properties, in addition to larvicidal activities against Aedes aegypti and toxicity against the cattle tick. Therefore, this review about the work performed by PRONABio, emphasizes the potential of the biomes of Mato Grosso do Sul as sources of substances of medicinal and veterinary interest, and also relevant to public health.

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Constituintes químicos das folhas de Riedeliella graciliflora Harms (Leguminosae)

Cited by 12 publications

References 8 publications

Antimycobacterial and Nitric Oxide Production Inhibitory Activities of Triterpenes and Alkaloids from Psychotria nuda (Cham. & Schltdl.) Wawra

Antimycobacterial and Nitric Oxide Production Inhibitory Activities of Triterpenes and Alkaloids from Psychotria nuda (Cham. & Schltdl.) Wawra

Triterpenes and Other Constituents from Fruits of Enterolobium contortisiliquum (Vell.) Morong (Fabaceae)

The Chemical Diversity from the Vegetation of Mato Grosso do Sul and its Relevance as a Source of Bioactive Molecules

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