Nanostructured systems containing an essential oil: protection against volatilization

Flôres, Fabíola Niederauer; Ribeiro, Roseane Fagundes; Ourique, Aline Ferreira; Rolim, Clarice Madalena Bueno; Silva, Cristiane de Bona da; Pohlmann, Adriana Raffin; Beck, Ruy Carlos Ruver; Guterres, Sı́lvia Stanisçuaski

doi:10.1590/s0100-40422011000600010

Cited by 86 publications

(40 citation statements)

References 22 publications

(33 reference statements)

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Section: Ne Containing Eucalyptus Oil (Eucalyptus Globulus)mentioning

confidence: 73%

“…Due to the presence of the polymeric wall in the NC, these systems were considered more adequate to avoid the volatilization of the oil. Moreover, NE also showed a protection against oil volatilization compared to the coarse emulsions, although this provided less protection than that observed for NC (Flores et al, 2011).Benzophenone-3 was used to prepare NE and polymeric NC with oil phase composed by grape seed oil and almond kernel oil. All formulations appeared macroscopically homogeneous and their aspects were similar to a milky bluish opalescent fluid.…”

mentioning

confidence: 99%

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The use of Brazilian vegetable oils in nanoemulsions: an update on preparation and biological applications

Bajerski

Michels

Colomé

et al. 2016

Braz. J. Pharm. Sci.

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Vegetable oils present important pharmacological properties, which gained ground in the pharmaceutical field. Its encapsulation in nanoemulsions is considered a promising strategy to facilitate the applicability of these natural compounds and to potentiate the actions. These formulations offer several advantages for topical and systemic delivery of cosmetic and pharmaceutical agents including controlled droplet size, protection of the vegetable oil to photo, thermal and volatilization instability and ability to dissolve and stabilize lipophilic drugs. For these reasons, the aim of this review is to report on some characteristics, preparation methods, applications and especially analyze recent research available in the literature concerning the use of vegetable oils with therapeutic characteristics as lipid core in nanoemulsions, specially from Brazilian flora, such as babassu (Orbignya oleifera), aroeira (Schinus molle L.), andiroba (Carapa guaianiensis), casca-de-anta (Drimys brasiliensis Miers), sucupira (Pterodon emarginatus Vogel) and carqueja doce (Stenachaenium megapotamicum) oils.Uniterms: Plant oils/nanoemulsions/preparation. Plant oils/biological applications. INTRODUCTIONThe use of submicrometric colloidal nanocarriers such as nanoparticles (NP) lipid and polymeric, nanoemulsions (NE), microemulsions (ME), liposomes, and polymeric micelles is considered a promising system in the pharmaceutical field, because they have numerous advantages over traditional formulations such as: sustained release of the active element; solubilization of lipophilic molecules; use for different routes of administration; protection from chemical and enzymatic degradation of labile molecules; reduction of vegetable oils (VO) volatilization, side effects and dose (Mäder, Mehnert, 2005;Mehnert, Mäder, 2001;Gref, Couvreour, 2006;Couvreur, Vauthier, 2006; Panyam, Labhasetwar, 2003;Soppimath et al., 2001;Ai et al., 2011; Contri et al., 2012;Contri et al., 2014;Dimer et al., 2014;Severino et al., 2015;Frank et al., 2015;Asbahani et al., 2015). However, all systems differ thermodynamic stability, structure, chemical composition, efficiency encapsulation and types of application (Mäder, Mehnert, 2005;Ai et al., 2011).The development of suitable nanocarriers for pharmaceutical or cosmetic application requires the adequate selection of their adjuvants such as polymers for nanocapsules (NC), surfactants, and oils (Schaffazick et al., 2003;Alvarez-Román et al., 2001;Bouchemal et al., 2004;Friedrich et al., 2008). Recently, special attention has been given to the type of oily phase used as the core in the preparation of NE. VO has been preferred not only due to the concept that it is safe and biocompatible, but mainly because of the diversity of benefits, and the complex composition of fatty acids can exercise under the skin, protecting it against dehydration, solar radiation, inflammation, insect attack, microorganisms, and viruses (Tadros, Kessell, 2004;Bloise, 2003;Oyedeji, Okeke, 2010;Bakkali et. al., 2008;Harris, 2002; Contri et al, ...

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Section: Ne Containing Eucalyptus Oil (Eucalyptus Globulus)mentioning

confidence: 73%

mentioning

confidence: 99%

The use of Brazilian vegetable oils in nanoemulsions: an update on preparation and biological applications

Bajerski

Michels

Colomé

et al. 2016

Braz. J. Pharm. Sci.

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“…Com isso, observou-se atividade antimicrobiana em 100% (24/24) dos isolados, sem haver diferença estatística entre as associações. Acredita-se que esse resultado esteja relacionado à dose inicial de ataque, oferecida pelo OL, e a manutenção desta pelo controle da liberação do óleo proporcionado pelas nanoestruturas (Flores et al, 2011). O efeito antimicrobiano do óleo ocorreu imediatamente após a sua aplicação, possivelmente devido ao contato direto com a membrana do micro-organismo, provocando alterações na permeabilidade da membrana e inibição da respiração celular, conforme sugerido por Carson et al (2006).…”

Section: Resultsunclassified

“…As nanoemulsões e nanocápsulas contendo M. alternifolia a 1% (10mg/mL) (Flores et al, 2011) foram preparadas pelos métodos de emulsificação espontânea (Bouchemal et al, 2004) e deposição interfacial do polímero pré-formado de poli (ε-caprolactona) (Fessi et al, 1989), respectivamente, apresentando tamanho na faixa nanométrica (cerca de 200nm), potencial zeta negativo e índice de polidispersão abaixo de 0,25.…”

Section: Methodsunclassified

Atividade de nanoformulações de Melaleuca alternifolia e terpinen-4-ol em isolados de Rhodococcus equi

Sagave

Gressler

Flôres

et al. 2015

Arq. Bras. Med. Vet. Zootec.

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RESUMORhodococcus equi é o agente etiológico da rodococose equina, importante doença respiratória de potros. Especialmente na última década, a emergência de cepas resistentes aos antimicrobianos empregados no tratamento da rodococose tem sido relatada. Nesse sentido, há a necessidade de estudos envolvendo terapias alternativas e novas tecnologias, incluindo o uso de plantas medicinais e nanotecnologia. Neste trabalho utilizou-se Melaleuca alternifolia nas seguintes formulações: óleo livre, nanocápsula, nanoemulsão e a combinação de óleo livre com nanocápsula e com nanoemulsão, além do seu composto majoritário, terpinen-4-ol, a fim de verificar a atividade antimicrobiana frente a isolados de R. equi de diferentes origens. Utilizou-se o método de microdiluição em caldo na determinação das concentrações inibitória mínima (CIM) e bactericida mínima (CBM) das diferentes formulações frente aos isolados (n=24). Verificou-se baixo potencial para atividade antibacteriana de M. alternifolia na formulação de óleo livre. Todavia, essa atividade foi potencializada quando se incorporou o óleo essencial às nanoformulações. O composto terpinen-4-ol demonstrou potencial atividade antibacteriana quando incorporado ao óleo essencial e quando utilizado isoladamente. Verificou-se que tanto M. alternifolia quanto terpinen-4-ol testados possuem atividade antimicrobiana contra isolados de R. equi, sugerindo seu emprego em estudos avaliando seu potencial para o tratamento da rodococose.Palavras-chave: planta medicinal, nanotecnologia, rodococose, teste de susceptibilidade ABSTRACT Rhodococcus equi causes rodococose in horses, characterized by bronchopneumonia in foals. Due to reports of antimicrobial resistance, it is important to develop studies involving alternative therapies and new technologies, including the use of medicinal plants and nanotechnology. In this work, the plant

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“…Pengukuran stabilitas coarse emulsion dilakukan dengan uji stabilitas emulsi menggunakan metode sentrifugasi dan menghitung nilai emulsifying activity (EA) sesuai metode yang ditulis oleh Wu (2011), melihat ukuran partikel dengan light microscope dan mengukur batas-batas lapisan yang terpisah selama penyimpanan (Weiss, 2002). Adapun untuk fine emulsion dilakukan pengukuran zeta potential (Aljamali, 2015), ukuran droplet emulsi dengan particle size analyser (PSA) (Ali, 2014) dan bentuk droplet emulsi dengan transmission electron microscope (TEM) (Flores et al, 2011). Stabilitas emulsi diukur dengan menghitung nilai creaming index (CI) selama penyimpanan sesuai rumus yang ditulis oleh McClement (2005).…”

Section: Analisisunclassified

PEMANFAATAN TEPUNG PORANG (Amorphophallusoncophyllus) SEBAGAI PENSTABIL EMULSI M/A DAN BAHAN PENYALUT PADA MIKROKAPSUL MINYAK IKAN

Anwar¹,

Ginting²,

Aisyah³

et al. 2017

j.tek.ind.pert

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This research was aimed to investigate the ability of porang (Amorphophallus oncophyllus) flour to stabilizeoil-in-water (O/W ABSTRAKPenelitian ini didasari atas upaya untuk menemukan biopolimer alami yang tumbuh di Indonesia yang berpotensi digunakan sebagai bahan penyalut dalam proses mikroenkapsulasi bahan pangan. Secara khusus, penelitian ini bertujuan untuk menguji kemampuan tepung porang (Amorphophallus oncophyllus) sebagai penstabil emulsi minyak dalam air (m/a) dan bahan penyalut pada mikrokapsul minyak ikan.Penelitian ini terbagi atas 3 tahap. Tahap pertama adalah pembuatan coarse emulsion (CE) menggunakan ultra turrax (UT) dengan desain penelitian menggunakan rancangan acak kelompok yang terdiri dari dua faktor. Faktor pertama adalah konsentrasi tepung porang (kadar glukomanan 55%) yang terdiri atas dua taraf yaituT1 = 0,5% dan T2 = 1%. Faktor kedua adalah konsentrasi minyak terdiri atastigataraf yaitu M1 = 20%, M2 = 30% dan M3 = 40%. Tahap kedua adalah pembuatan fine emulsion (FE) menggunakan high pressure homogenizer (HPH) dan tahap ketiga adalah pengeringan FE menggunakan spray dryer. Tepung porang yang digunakan berwarna kuning dengan kadar air 7,75%, kadar abu 8,00%, kadar serat 9,72%, kadar lemak 0,43%, dan kadar glukomanan 55,54%. Berdasarkan hasil penelitian, konsentrasi tepung porang, konsentrasi minyak dan interaksi antara konsentrasi tepung porang (T) dan konsentrasi minyak (M) berpengaruh sangat nyata (P≤0,01) terhadap nilai emulsifying activity (EA) dan viskositas emulsi. CE yang paling stabil adalah emulsi dengan konsentrasi minyak 40% dan tepung porang 1%, dengan viskositas 3647 cP, nilai EA100% dan pemisahan serum 2,70 mL setelah 7 hari peyimpanan. FE yang paling stabil diperoleh dari kombinasi perlakuan yang sama dengan ukuran partikel ratarata 614 nm, polydispersity index (PdI) 0,237, zeta potential -25,83 mV, dan pemisahan serum 0,25 mL setelah 16 hari penyimpanan. Nilai bilangan peroksida (PV) mikrokapsul berkisar antara 16.5 -32.5 meq/kg minyak.Kata kunci: tepung porang, glukomanan, emulsi (m/a), stabilitas emulsi, penstabil PENDAHULUAN Salah satu biopolimer alami yang berpotensi digunakan sebagai bahan penyalut adalah porang atau iles-iles (Amorphopallus onchopillus). Tanaman ini hanya terdapat di daerah tropis dan subtropis. Pemanfaatan porang dalam industri pangan ataupun non pangan masih sangat kurang. Porang tidak dapat diolah langsung menjadi makanan karena kandungan kalsium oksalat yang menyebabkan rasa gatal, sehingga sering diolah terlebih dahulu menjadi tepung atau gaplek.

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Nanostructured systems containing an essential oil: protection against volatilization

Cited by 86 publications

References 22 publications

The use of Brazilian vegetable oils in nanoemulsions: an update on preparation and biological applications

The use of Brazilian vegetable oils in nanoemulsions: an update on preparation and biological applications

Atividade de nanoformulações de Melaleuca alternifolia e terpinen-4-ol em isolados de Rhodococcus equi

PEMANFAATAN TEPUNG PORANG (Amorphophallusoncophyllus) SEBAGAI PENSTABIL EMULSI M/A DAN BAHAN PENYALUT PADA MIKROKAPSUL MINYAK IKAN

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