Alcaloides indólicos de cascas de Aspidosperma vargasii e A. desmanthum

Henrique, Marycleuma Campos; Nunomura, Sergio Massayoshi; Pohlit, Adrian Martin

doi:10.1590/s0100-40422010000200010

Cited by 31 publications

(25 citation statements)

References 16 publications

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“…Aspidosperma species from various parts of the Amazon and elsewhere ( -Neto et al, 2007;Henrique et al, 2010;Montoia et al, 2014), uleine from A. parvifolium A. DC. , aricin, tchibangensin and tetrahydrousambarensin from A. marcgravianum Woodson (Passemar et al, 2011), usambarensinde and ochrolifuanin from A. oblongum A. DC.…”

Section: Anti-malarial Activity Of the Plant Species Used In The Negrmentioning

confidence: 99%

An ethnobotanical study of anti-malarial plants among indigenous people on the upper Negro River in the Brazilian Amazon

Frausin

Hidalgo

Lima

et al. 2015

Journal of Ethnopharmacology

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Section: Anti-malarial Activity Of the Plant Species Used In The Negrmentioning

confidence: 99%

An ethnobotanical study of anti-malarial plants among indigenous people on the upper Negro River in the Brazilian Amazon

Frausin

Hidalgo

Lima

et al. 2015

Journal of Ethnopharmacology

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“…The alkaloids were identified by 1 H-and 13 C-NMR spectroscopy and comparison with literature data. [44,45] B. riedelianum: The crude extract (13 g) was subjected to VLC on silica gel, taking 500 mL fractions, using a cyclohexane/AcOEt gradient with 10 % increments, and finally washing with MeOH. The fractions eluted with cyclohexane/AcOEt (3:7) and (2:8) contained kokusaginine (4) and flindersiamine (5).…”

Section: Extraction and Purificationmentioning

confidence: 99%

Isolation and Antimacrofouling Activity of Indole and Furoquinoline Alkaloids from ‘Guatambú’ Trees (Aspidosperma australe and Balfourodendron riedelianum)

Pérez

Diez

Valdez

et al. 2019

Chemistry & Biodiversity

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In this work, the antifouling activity of five alkaloids, isolated from trees of the Atlantic rainforest, was studied. The tested alkaloids were olivacine (1), uleine (2) and N‐methyltetrahydroellipticine (3) from Aspidosperma australe (‘yellow guatambú’) and the furoquinoline alkaloids kokusaginine (4) and flindersiamine (5) from Balfourodendron riedelianum (‘white guatambú’). All these compounds can be isolated from their natural sources in high yields in a sustainable way. The five compounds were subjected to laboratory tests (attachment test of the mussel Mytilus edulis platensis) and field trials, by incorporation into soluble matrix paints, and 45 days of exposure of the painted panels in the sea. The results show that compound 3 is a very potent antifoulant, and that compounds 4 and 5 are also very active, while compounds 1 and 2 did not show any significant antifouling activity. These results open the way for the development of environmentally friendly antifouling agents, based on abundant and easy‐to‐purify compounds that can be obtained in a sustainable way.

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“…É importante destacar os principais metabólitos e suas funções já desvendadas. Os alcaloides possuem propriedade antibacteriana, antifúngica, antiplasmódica e antitumoral (SILVA et al, 2007;HENRIQUE et al, 2010) pela capacidade de desestabilizar as membranas biológicas. Também apresentam a capacidade de inibir a síntese de DNA e RNA ao se ligarem aos ácidos nucleicos e se intercalarem à dupla hélice (SIMÕES et al 2010).…”

Section: Metabolismo Vegetal: Metabólitos Primários E Secundáriosunclassified

Técnicas De Prospecção Fitoquímica E Sua Importância Para O Estudo De Biomoléculas Derivadas De Plantas

Soares¹,

Santos²,

Vieira³

et al. 2016

Enci Bio

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RESUMOAs plantas medicinais são utilizadas desde a antiguidade e esse conhecimento tradicional é passado pelas gerações e podem orientar o estudo de moléculas bioativas, na pesquisa de princípios ativos ou na produção de medicamentos. Os metabólitos secundários são compostos químicos produzidos pelas plantas derivados do metabolismo primário da glicose e atuam na ecologia dos vegetais por meio de funções como atração de polinizadores e dispersores, defesa contra herbivoria e radiação entre outras. A fitoquímica atua no estudo dos metabólitos secundários e a prospecção fitoquímica irá detectar a presença desses e, com isso, orientar as demais etapas do estudo dos vegetais para produção de medicamentos e fitoterápicos. A prospecção pode ser realizada por testes de reações químicas ou por métodos cromatográficos. Os primeiros possuem baixo custo e são mais simples, os segundos necessitam de equipamentos dispendiosos e treinamento adequado para utilização, porém, são mais eficazes no estudo e podem ser utilizados nas demais etapas da investigação fitoquímica. Atualmente, os métodos mais utilizados são por reações químicas e investigações adicionais são realizadas juntamente com a prospecção fitoquímica. Tais estudos são importantes para a pesquisa farmacêutica, para a filogenética e principalmente na preservação dos recursos vegetais dos diferentes biomas brasileiros. PALAVRAS-CHAVE: Farmacognosia, metabolismo vegetal, Plantas medicinais; Química experimental. PHITOCHEMICAL PROSPECTING TECHNIQUES AND THEIR IMPORTANCE TO THE STUDY OF BIOMOLECULAS DERIVED FROM PLANTSABSTRACT Medicinal plants have been used since ancient times and that traditional knowledge is passed through generations and can guide the study of bioactive molecules in the active ingredients research or the production of medicines. Secondary metabolites are chemical compounds produced by plants derived from primary metabolism of glucose and act on the plant ecology through functions such as attracting pollinators

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Alcaloides indólicos de cascas de Aspidosperma vargasii e A. desmanthum

Cited by 31 publications

References 16 publications

An ethnobotanical study of anti-malarial plants among indigenous people on the upper Negro River in the Brazilian Amazon

An ethnobotanical study of anti-malarial plants among indigenous people on the upper Negro River in the Brazilian Amazon

Isolation and Antimacrofouling Activity of Indole and Furoquinoline Alkaloids from ‘Guatambú’ Trees (Aspidosperma australe and Balfourodendron riedelianum)

Técnicas De Prospecção Fitoquímica E Sua Importância Para O Estudo De Biomoléculas Derivadas De Plantas

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