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Food deserts have been widely studied in Western contexts but rarely in transitioning economies and never within a rainforest. The Brazilian Amazon is a rapidly urbanizing region with high levels of poverty and food insecurity, providing an ideal context in which to explore this current research gap. Within this setting, five urban centers ranging from small town to metropole are examined to explore any potential variations between urban centers of different sizes and settings. A large survey was conducted with interviews in 554 food shops, assessing shop characteristics, food availability, price, and alternative household food acquisition strategies. Methods were developed to explore food deserts, accounting for food acquisition across multiple shops within a neighborhood. Insufficient access to healthy food was estimated to be widespread (42 percent of households), with access worse in smaller towns. Unlike many previous studies, local access to healthy food was not linked to neighborhood poverty and prices were generally lower in poorer areas. High levels of nonretail sourcing of food (e.g., fruit trees, fishing) in this region might lead to an overestimation of the food access problem if only retail food provision were considered. We conclude that food deserts are widespread in the rainforest cities studied, yet we highlight the importance of understanding local retail and nonretail food contexts. Finally, we question the extent to which the traditional food desert concept can be directly applied in the context of transitioning economies.

Plasmodium falciparum and P. vivax malaria parasites are now resistant, or showing signs of resistance, to most drugs used in therapy. Novel chemical entities that exhibit new mechanisms of antiplasmodial action are needed. New antimalarials that block transmission of Plasmodium spp. from humans to Anopheles mosquito vectors are key to OPEN ACCESSMolecules 2013, 18 9220 malaria eradication efforts. Although P. vivax causes a considerable number of malaria cases, its importance has for long been neglected. Vivax malaria can cause severe manifestations and death; hence there is a need for P. vivax-directed research. Plants used in traditional medicine, namely Artemisia annua and Cinchona spp. are the sources of the antimalarial natural products artemisinin and quinine, respectively. Based on these compounds, semi-synthetic artemisinin-derivatives and synthetic quinoline antimalarials have been developed and are the most important drugs in the current therapeutic arsenal for combating malaria. In the Amazon region, where P. vivax predominates, there is a local tradition of using plant-derived preparations to treat malaria. Here, we review the current P. falciparum and P. vivax drug-sensitivity assays, focusing on challenges and perspectives of drug discovery for P. vivax, including tests against hypnozoites. We also present the latest findings of our group and others on the antiplasmodial and antimalarial chemical components from Amazonian plants that may be potential drug leads against malaria.

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ABSTRACT-Species of the Annonaceae family are used all over the tropics in traditional medicine in tropical regions for the treatment of malaria and other illnesses. Phytochemical studies of this family have revealed chemical components which could offer new alternatives for the treatment and control of malaria. Searches in scientific reference sites (SciFinder Scholar, Scielo, PubMed, ScienceDirect and ISI Web of Science) and a bibliographic literature search for species of Annonaceae used traditionally to treat malaria and fever were carried out. This family contains 2,100 species in 123 genera. We encountered 113 articles reporting medicinal use of one or more species of this family including 63 species in 27 genera with uses as antimalarials and febrifuges. Even though the same species of Annonaceae are used by diverse ethnic groups, different plant parts are often chosen for applications, and diverse methods of preparation and treatment are used. The ethanol extracts of Polyalthia debilis and Xylopia aromatica proved to be quite active against Plasmodium falciparum in vitro (median inhibition concentration, IC 50 < 1.5 µg/mL). Intraperitoneal injection of Annickia chlorantha aqueous extracts (cited as Enantia chlorantha) cleared chloroquine-resistant Plasmodium yoelii nigeriensis from the blood of mice in a dose-dependant manner. More phytochemical profiles of Annonaceous species are required; especially information on the more commonly distributed antimalarial compounds in this family.

RESUMO: Plantas da família Araceae para a malária e doenças relacionadas: uma revisão. No presente trabalho realizamos uma revisão das espécies da família Araceae usadas para tratar malária e seus sintomas. O objetivo foi revelar o grande número de espécies da família usadas no mundo, assim como seu potencial como fontes de produtos naturais antimaláricos. Foram consultadas as plataformas de busca SciFinder Scholar, Scielo, PubMed, ScienceDirect e Google books. Encontramos quarenta e três registros de 36 espécies e 23 generos de Aráceas usadas para tratar malária e seus sintomas. Os generos neotropicais Philodendron Schott e Anthurium Schott foram os melhor representados, úteis para o tratamento da malária, febres, problemas hepáticos e dores de cabeça. Folhas e tubérculos foram as partes mais utilizadas, enquanto a decocção foi o método de preparo mais comum. Os extratos de espécies de Araceae inibem o crescimento in vitro do parasito da malária humana, Plasmodium falciparum Welch, e concentrações inibitórias medianas (CI 50 ) significativas foram relatadas para extratos de guaimbê-sulcado (Rhaphidophora decursiva (Roxb.) Schott), aninga (Montrichardia linifera (Arruda) Schott), Culcasia lancifolia N.E. Br. e anchomanes do mato (Anchomanes difformis (Blume) Engl.), demonstrando o potencial antimalárico e citotóxico de extratos e subfrações. No único relato sobre os componentes antimaláricos dessa família, a neolignana polisiforina e o benzoperóxido rafidecurperoxina apresentaram forte inibição das cepas D6 e W2 de Plasmodium falciparum in vitro (CI 50 = 368-540 ng/mL). Nenhum estudo sobre a atividade antimalárica in vivo em modelo animal foi realizado com espécies da família Araceae. Mais trabalhos biomonitorados pela composição química sobre a atividade antimalárica in vitro, assim como estudos in vivo, são necessários para aprofundar os conhecimentos sobre potencial antimalárico da familia. Palavras-chave:Anthurium, Philodendron, Rhaphidophora decursiva, Plasmodium falciparum, planta antimalárica. ABSTRACT:In the current work we performed a review of the Araceae family species traditionally used to treat malaria and its symptoms. The aim is to reveal the large number of antimalarial Araceae species used worldwide and their great unexplored potential as sources of antimalarial natural products. The SciFinder Scholar, Scielo, PubMed, ScienceDirect and Google books search engines were consulted. Forty-three records of 36 species and 23 genera of Araceae used for malaria and symptoms treatment were found. The neotropical genera Philodendron Schott and Anthurium Schott were the best represented for the use in the treatment of malaria, fevers, liver problems and headaches. Leaves and tubers were the most used parts and decoction was the most common preparation method. The extracts of Araceae species inhibit the in vitro growth of the human malaria parasite, the Plasmodium falciparum Welch, and significant median inhibitory concentrations (IC 50 ) for extracts of guaimbê-sulcado (Rhaphidophora decursiva (Roxb.) Scho...

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ResumenLos estudios etnobotánicos de grupos indígenas desplazados en Colombia son escasos. Este avance de investigación presenta una lista de 54 especies de plantas (50 géneros en 32 familias) usadas por una comunidad indígena murui-muinane (= uitoto, witoto, huitoto) desplazada a la ciudad de Florencia, capital del departamento del Caquetá. Sólo seis (11%) especies de las plantas usadas no son nativas de América. Arecaceae y Fabaceae fueron las familias con el mayor número de especies empleadas: ocho y seis respectivamente. Las tres categorías de uso con el mayor número de especies de plantas utilizadas fueron: alimenticia (27 spp.), medicinal (15) y artesanal (15). Estas 54 especies de plantas corresponden al 19% del total de plantas útiles registradas para una comunidad murui que vive en una reserva de bosque en el Putumayo. Es importante mencionar esta diferencia en el número de plantas útiles si tenemos en cuenta que las culturas indígenas de Colombia se están transformando rápidamente y que su conocimiento etnobotánico puede perderse para siempre. Amazonia, etnobotánica, witoto, huitoto, uitoto. plants used By a displaced murui-muinane indigenous community in the city of florencia (caqueta, colomBia) Palabras clave: AbstractEthnobotanical studies on the displaced indigenous groups of Colombia are scarce. This research report provides a list of 54 plant species (50 genera in 32 families) used by a displaced group of Murui-Muinane (= Witoto, Uitoto, Huitoto) that lives in the city of Florencia, capital of the Department of Caqueta. Only six (11%) plant species are not native to the Americas. Arecaceae and Fabaceae were the families with the highest number of species: eight and six respectively. The three categories of use with the highest number of species were: food (27 spp.), medicinal (15) and handicrafts (15). These 54 plant species used by the Murui in Florencia correspond to 19% of the total number of plants recorded as used by a Murui community that lives in a forested reservation in the Department of Putumayo. Such difference in the number of useful plants is noteworthy given that Colombian indigenous cultures are rapidly transforming and their ethnobotanical knowledge might be lost forever.