Saponinas antifúngicas de Swartzia langsdorffii

Marqui, Sara Regina de; Lemos, Renata Brionízio; Santos, Luciana Ávila; Castro‐Gamboa, Ian; Cavalheiro, Alberto José; Bolzani, Vanderlan da Silva; Silva, Dulce Helena Siqueira; Scorzoni, Liliana; Fusco-Almeida, A. M.; Mendes-Giannini, María José Soares; Young, Maria Cláudia Marx; Torres, Luce Maria Brandão

doi:10.1590/s0100-40422008000400023

Cited by 13 publications

(13 citation statements)

References 7 publications

(16 reference statements)

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“…Amphotericin B and Chloramphenicol (Sigma Chemical Co.) were used as the reference antimycotic and antibacterial controls, respectively, on the basis of their use as reference antimicrobial compounds in bioassays with crude medicinal plant extracts (2, 7, 14, 17, 20, 25). …”

Section: Methodsmentioning

confidence: 99%

Antimicrobial activity of some medicinal plants from the cerrado of the central-western region of Brazil

Violante

Hamerski

Garcez

et al. 2012

Braz. J. Microbiol.

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Ethanol extracts from six selected species from the Cerrado of the Central-Western region of Brazil, which are used in traditional medicine for the treatment of infectious diseases and other medical conditions, namely Erythroxylum suberosum St. Hil. (Erythroxylaceae), Hyptis crenata Pohl. ex Benth. (Lamiaceae), Roupala brasiliensis Klotz. (Proteaceae), Simarouba versicolor St. Hil. (Simaroubaceae), Guazuma ulmifolia Lam. (Sterculiaceae) and Protium heptaphyllum (Aubl.) March. (Burseraceae), as well as fractions resulting from partition of these crude extracts, were screened in vitro for their antifungal and antibacterial properties. The antimicrobial activities were assessed by the broth microdilution assay against six control fungal strains, Candida albicans, C. glabrata, C. krusei, C. parapsilosis, C. tropicalis and Cryptococcus neoformans, and five control Gram-positive and negative bacterial strains, Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae, Pseudomonas aeruginosa and Staphylococcus aureus. Toxicity of the extracts and fractions against Artemia salina was also evaluated in this work. All plants investigated showed antimicrobial properties against at least one microorganism and two species were also significantly toxic to brine shrimp larvae. The results tend to support the traditional use of these plants for the treatment of respiratory and gastrointestinal disorders and/or skin diseases, opening the possibility of finding new antimicrobial agents from these natural sources. Among the species investigated, Hyptis crenata, Erythroxylum suberosum and Roupala brasiliensis were considered the most promising candidates for developing of future bioactivity-guided phytochemical investigations.

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Section: Methodsmentioning

confidence: 99%

Antimicrobial activity of some medicinal plants from the cerrado of the central-western region of Brazil

Violante

Hamerski

Garcez

et al. 2012

Braz. J. Microbiol.

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“…Such changes in secondary metabolism induce the production of defense substances as responses to changes in the plant habitat (SALISBURY;. In this way, Marqui et al (2008) reported the saponin triterpene action against human pathogens and against phytopathogenic fungi Cladosporium cladosporioides and C. sphaerospermum.…”

Section: Resultsmentioning

confidence: 99%

Antifungal potential and phytochemistry of Tetrapterys multiglandulosa CAV aerial parts

Facco¹,

Müller²,

Matias³

et al. 2016

Biosci. J.

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Tetrapterys spp. are considered toxic to grazing animals owing to the presence of a poisonous constituent cardiotonic glycoside. However, other chemicals within the plant have allelopathic, bactericidal, and fungicidal activities. The objective of this study was to search for natural products as alternatives in the control of plant pathogenic fungi, which diminish the crop productivity and cause damage to animal and human health. The phytochemical content of the stems and leaves was investigated alongside the fungitoxic potential of aqueous and ethanol extracts from aerial parts of T. multiglandulosa on Fusarium moniliforme and F. graminearum. The leaves and stems were obtained from 20 arrays of T. multiglandulosa from Batayporã City, south of Mato Grosso do Sul, and classified as young and mature. The botanical material was oven dried, crushed, and its aqueous and 20% ethanol extracts were used for qualitative and quantitative phytochemical assays. For in vitro tests of fungal growth inhibition, extract concentrations of 200, 400, 800, 1600, and 2000 µg L -1 were assayed, with two control groups. Phytochemical tests from aqueous and ethanol extracts of young and mature leaves indicated the presence of phenolic compounds, tannins, flavonoids, saponins, alkaloids, and cardiotonic glycosides. The aqueous extract of young leaves showed potential fungicidal activity against F. graminearum, with values ranging from 21.25% to 33.53% colony growth inhibition.

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“…It has been reported that its extract contains isoflavonoids, which might be responsible for the observed activity. [28][29][30] The DPPH test is easy to perform, reliable and reproducible, for this reason has been widely used in the analysis of antioxidant activities, both in EPR spectroscopy and in the bleaching technique, which measures the optical absorption intensity at 515-517 nm. The fact that the DPPH EPR spectrum has a relatively simple signal due only to the free radical is an advantage in relation to the optical spectroscopy.…”

Section: Dpph Scavenging Testmentioning

confidence: 99%

Antioxidant properties of plant extracts: an EPR and DFT comparative study of the reaction with DPPH, TEMPOL and spin trap DMPO

Santos

Silva

Bolzani

et al. 2009

J. Braz. Chem. Soc.

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Este trabalho apresenta um estudo comparativo da atividade antioxidante dos extratos de nove espécies de plantas pertencentes à flora brasileira -Swartzia langsdorffii, Machaerium villosum, Pterogyne nitens, Pera glabrata, Aegiphyla sellowiana, Copaifera langsdorffii, Chrysophyllum inornatum, Iryanthera juruensis, Didymopanax venosum -neutralizando os radicais livres DPPH (2,2-difenil-1-picrilhidrazil) e TEMPOL (4-hidróxi-2,2,6,6-tetrametil-1-piperidiniloxi-1-oxil) utilizando ressonância paramagnética eletrônica (RPE), e agindo sobre os radicais hidroxila (OH·) gerados por uma reação Fenton, através da técnica de spin-trapping. Os melhores resultados foram obtidos para os extratos de Iryanthera juruensis e Chrysophyllum inornatum. Os resultados dos testes foram acompanhados por cálculos computacionais dos compostos, utilizando a teoria do funcional da densidade (TFD), com aproximação local da densidade (ALD), e o código SIESTA. Os resultados indicaram que a energia liberada na reação de redução TEMPOL é inferior a DPPH. Como o DPPH é um composto de menor custo e mais disponível tem um uso mais amplo que o TEMPOL, entretanto este último deve ser considerado quando se quer estudar processos que envolvam menores energias.This work presents a comparative study of the antioxidant activity of extracts from nine plant species belonging to the Brazilian flora -Swartzia langsdorffii, Machaerium villosum, Pterogyne nitens, Pera glabrata, Aegiphyla sellowiana, Copaifera langsdorffii, Chrysophyllum inornatum, Iryanthera juruensis, Didymopanax venosum -acting on the free-radicals DPPH (2,2-diphenyl-1-picrylhydrazyl) and TEMPOL (4-hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy-1-oxyl) by electron paramagnetic resonance (EPR), and acting on the hydroxyl radical (OH·) by the spintrapping technique generated by a Fenton reaction. Results showed that the extracts of Iryanthera juruensis and Chrysophyllum inornatum display the strongest antioxidant activities. The results of scavenging tests were clarified by computational calculations -density functional theory (DFT), local density approximation (LDA) with SIESTA code -indicating that the energy released in the reduction reaction of TEMPOL is less than DPPH. Due to its availability and cost DPPH is more often used in these tests than TEMPOL, however TEMPOL should be considered when studying processes dealing with smaller energies.

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Saponinas antifúngicas de Swartzia langsdorffii

Cited by 13 publications

References 7 publications

Antimicrobial activity of some medicinal plants from the cerrado of the central-western region of Brazil

Antimicrobial activity of some medicinal plants from the cerrado of the central-western region of Brazil

Antifungal potential and phytochemistry of Tetrapterys multiglandulosa CAV aerial parts

Antioxidant properties of plant extracts: an EPR and DFT comparative study of the reaction with DPPH, TEMPOL and spin trap DMPO

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