Ocorrência e atividade biológica de quassinóides da última década

Almeida, Maria Mozarina Beserra; Arriaga, Ângela M. C.; Santos, Allana Kellen L.; Lemos, Telma L. G.; Braz-Filho, Raimundo; Vieira, Ivo José Curcino

doi:10.1590/s0100-40422007000400033

Cited by 34 publications

(22 citation statements)

References 44 publications

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“…The quassinoids are a class of substances found almost exclusively in plants of the Simaroubaceae family and exhibiting a wide range of biological activities (Almeida et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Anti-hiperglycemic effect of Quassia amara (Simaroubaceae) in normal and diabetic rats

Ferreira

Azevedo

Vardanega-Peicher

et al. 2013

Rev. bras. plantas med.

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ABSTRACT:The anti-hyperglycemic effect of wood powder of Quassia amara (QA) was evaluated in normal and in alloxan diabetes-induced rats. After a 12 h fast and glycemic check, the animals were orally given 0.9% of saline (control group), metformin (500 mg/kg) or QA (200 mg/kg) and, 30 minutes later, they received an oral glucose dose (1g/kg). The blood glucose level was measured after 30, 60, 90 and 120 minutes. From the oral glucose dose, QA showed anti-hyperglycemic effects, similar to metformin, only in the diabetic animals (p<0.01) when compared to the control group. Although the anti-hyperglycemic mechanism of action of QA was not investigated, a mechanism similar to metformin can be suggested, since both presented similar results for the conditions tested, that is, normal and diabetic rats. It is believed that the use of QA in diabetics could help to control the blood glucose levels and be useful as an alternative therapy.Keywords: alloxan, anti-hyperglicemic effect, diabetes, Quassia amara RESUMO: Efeito anti-hiperglicêmico de Quassia amara (Simaroubaceae) em ratos normais e diabéticos. O efeito anti-hiperglicemiante do pó do lenho de Quassia amara (QA) foi avaliado em ratos normais e diabéticos aloxana induzidos. Após jejum de 12 horas e verificação da glicemia, os animais receberam administração oral de salina 0.9% (grupo controle), metformina (500 mg/kg) ou QA (200 mg/kg) e 30 minutos depois carga oral de glicose (1g/kg). A glicemia foi medida nos próximos 30, 60, 90 e 120 minutos. A partir da carga oral de glicose, a QA mostrou efeito anti-hiperglicemiante, similar a metformina, somente nos animais diabéticos (p<0.01) quando comparados ao grupo controle. Embora o mecanismo de ação anti-hiperglicemiante da QA não tenha sido investigado, podemos sugerir um mecanismo semelhante à metformina, visto que ambos apresentaram resultados similares nas duas condições testadas, ou seja, animais normais e diabéticos. Acredita-se que o uso de QA, em diabéticos, possa auxiliar no controle da glicemia e servir como terapia alternativa. Palavras-chave: aloxana, efeito anti-hiperglicemiante, diabetes, Quassia amaraRev. Bras. Pl. Med., Campinas, v.15, n.3, p.368-372, 2013.

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“…The quassinoids are a class of substances found almost exclusively in plants of the Simaroubaceae family and exhibiting a wide range of biological activities (Almeida et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Anti-hiperglycemic effect of Quassia amara (Simaroubaceae) in normal and diabetic rats

Ferreira

Azevedo

Vardanega-Peicher

et al. 2013

Rev. bras. plantas med.

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“…Quassinoids can be considered a taxonomic marker of the Simaroubaceae family since it is the most abundant group of natural substances and their synthe almost exclusive (Saraiva et al, 2006;Almeida et al, 2007).…”

Section: Chemical Constituentsmentioning

confidence: 99%

“…The principal geographical distribution center is located at tropical America, extending to the west to Africa, Madagascar, Asia (Malaysia) and regions of Australia bathed by the Pacific (Simão et al, 1991;Saraiva et al, 2002;). In Brazil, this family is represented by the genera Quassia and Picrolemma, in the Amazon, Castela and Picrasma, to the South; and Simaba, Simarouba and Picrolema, which are present troughout the country (Arriaga et al, 2002;Almeida et al, 2007) (Fig. 1).…”

Section: Introductionmentioning

confidence: 99%

Simaroubaceae family: botany, chemical composition and biological activities

Alves

Miranda

Soares

et al. 2014

Revista Brasileira de Farmacognosia

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“…Their diverse biological activities, such as antitumoral, antifeedant, insecticidal, antimalarial, among others, motivated investigation related to their organic chemistry and pharmacology. 7 Many of these natural products, isolated from plants, such as chaparrinone, 8 dihydroxyeuricomanol, 9 samaderines X and Z, orinocinolide, excelsite, and quassin, [10][11][12][13] ( Figure 1), have shown antimalarial activity. Owing to the wide spectrum of biological activities shown by this family of natural products, we postulate that their structure can be used as a privileged scaffold to prepare new bioactive compounds.…”

Section: Figurementioning

confidence: 99%