Estudo fitoquímico do decocto das folhas de Maytenus truncata Reissek e avaliação das atividades antinociceptiva, antiedematogênica e antiulcerogênica de extratos do decocto

Fonseca, A.P.N.D.; Silva, Grácia Divina de Fátima; Carvalho, Juliana de Jesus; Salazar, G.D.C. Meléndez; Duarte, Lucienir Pains; Silva, Renata Pamplona; Jorge, Rodrigo. M.; Tagliati, Carlos Alberto; Zani, Carlos Leomar; Alves, Tânia Maria de Almeida; Peres, Valdir; Filho, Sidney Augusto Vieira

doi:10.1590/s0100-40422007000400016

Cited by 15 publications

(17 citation statements)

References 14 publications

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“…The ethyl acetate and methanol extracts, when administered to rats at a dose of 120 and 240 mg/kg, showed a significant decrease in the severity of injuries [21].…”

Section: Maytenus Genusmentioning

confidence: 92%

“…Preparations obtained from the leaves of Maytenus ilicifolia are widely used in Brazil, where the plantis popularly known by different names, such as congorça, erva cancerosa, espinho-de-deus, quebrachillo, sombra-de-toro, concorosa, and finally the most commonly used name by the local population, "espinheira santa" or "espinheira." However, other species of this genus, such as Maytenus aquifolium, Maytenus Robusta, and Maytenus truncate, are also known by the same names and are also used in folk medicine to treat gastric disorders [19][20][21][22].…”

Section: Maytenus Genusmentioning

confidence: 99%

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Antiulcer Agents from Higher Plants

Klein‐Júnior

Santin

Andrade

2012

Plant Bioactives and Drug Discovery

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The gastrointestinal tract has its own conformation, with a large surface area that permits high absorption, and glands that produce digestive juices, thereby enabling digestion and absorption of nutrients, in order to maintain the functioning of the organism. One of the segments of the gastrointestinal tract is the stomach. This organ is formed by several layers of smooth muscle and is lined by a mucous membrane. It is anatomically divided into four regions: cardia, fundus, body, and antrum [1,2].The stomach surface contains mucus-secreting cells, which cover the entire surface; peptic cells, which secrete large amounts of pepsinogen; parietal cells, which secrete hydrochloric acid and intrinsic factor; G cells, which secrete gastrin; and chromaffin cells, which secrete histamine [3,4].The stomach has a series of protective barriers, for its primordial function, digestion of proteins, and protection against self-digestion and injuries. The mucosal layer plays a key role, with four levels of protection. The first level is the factors secreted into the lumen (surface phospholipids, bicarbonate, mucus, and prostaglandins); the second level of protection is the epithelium itself; the third level is related to the joint action of the afferent sensory nerve and the microcirculation mucosa and submucosa; and the fourth level of defense is the mucosal immune system, including mast cells and macrophages [5,6]. Thus, disorders involving the secretory and protector functions may be related to the pathogenesis of peptic ulcer [4].

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“…The ethyl acetate and methanol extracts, when administered to rats at a dose of 120 and 240 mg/kg, showed a significant decrease in the severity of injuries [21].…”

Section: Maytenus Genusmentioning

confidence: 92%

Section: Maytenus Genusmentioning

confidence: 99%

Antiulcer Agents from Higher Plants

Klein‐Júnior

Santin

Andrade

2012

Plant Bioactives and Drug Discovery

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“…Numerous species of Amazonian plants have medicinal properties, including those belonging to the therapeutically important Celastraceae family; these have a range of pharmacological activities such as anti-ulcer, insecticide, immunosuppressant, anti-rheumatic, antibacterial, anti-parasitic, and anti-cancer effects (11) (12) (13) . In Brazil, this family is represented by four genera: Austroplenckia, Franhofera, Maytenus, and Salacia (14) .…”

Section: Introductionmentioning

confidence: 99%

Screening of the in vitro antileishmanial activities of compounds and secondary metabolites isolated from Maytenus guianensis Klotzsch ex Reissek (Celastraceae) chichuá Amazon

Meneguetti

Lima

Hurtado

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Introduction:Maytenus guianensis is a member of the Celastraceae family that is used in traditional medicine, particularly for its anti-parasitic and anti-cancer effects. To explore the ethnopharmacological potential of this plant, the present study was designed to screen the in vitro antileishmanial activities of extracts and compounds isolated from M. guianensis. Methods: Maytenus guianensis stems and leaves were extracted in acetone, followed by the preparation of eluates and isolation of secondary metabolites using chromatography on a glass column with silica gel as the fixed phase. The chemical components were identified using spectroscopic methods, including one-and two-dimensional nuclear magnetic resonance of hydrogen-1 and carbon-13, mass spectroscopy, and infrared spectroscopy. The anti-Leishmania amazonensis activities of these eluates and compounds were evaluated by direct promastigote counting and viability assays. Results: It was found that the hexane bark eluate produced the strongest anti-L. amazonensis effect, with 90-100% inhibition of the promastigote form. The isolated metabolite that produced the best result was tingenone B, followed by a compound formed by the union of tingenone and tingenone B (80-90% inhibition). Conclusions: Maytenus guianensis shows anti-parasite activity that warrants further investigation to determine the mechanisms underlying this antileishmanial effect and to evaluate the pharmacological potential of these eluates and isolated secondary metabolites, while minimizing any adverse effects.

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“…The Celastraceae family comprises about 98 genera and about 1,264 species and it may be found throughout Brazil (OLIVEIRA et al, 2006;FONSECA et al, 2007). There are several studies that demonstrate that the principles of the biological interest are associated with flavonoids, sesquiterpenes, alkaloids, and pentacyclic triterpenes (GONÇALVES et al, 2005;MICHELIN et al, 2005;OLIVEIRA et al, 2006).…”

Section: Introductionmentioning

confidence: 99%