Os produtos naturais e a química medicinal moderna

Viegas, Cláudio; Bolzani, Vanderlan da Silva; Barreiro, Eliezer J.

doi:10.1590/s0100-40422006000200025

Cited by 173 publications

(166 citation statements)

References 36 publications

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“…The search for natural origin products with pharmacological properties has significantly contributed to the discovery of new substances that have important uses (Viegas Junior et al, 2006). In this sense, Brazil stands out as a potential source of these natural products for having the largest plant biodiversity on the planet and also because most of its plants are unexplored relative to their pharmacological potential (Pinto et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and antioxidant activity of essential oil and different plant extracts of Psidium cattleianum Sabine

et al. 2016

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The goals of the study were to determine: the antimicrobial and antioxidant activities of essential oil and plant extracts aqueous and ethanolic of Psidium cattleianum Sabine; the chemical composition of the essential oil of P. cattleianum; and the phytochemical screening of aqueous and ethanolic extracts of the same plant. Regarding the antimicrobial activity, the ethanolic extract exhibited moderate antimicrobial activity with respect to bacteria K. pneumoniae and S. epidermidis, whereas, regarding other microorganisms, it showed activity considered weak. The aqueous extract and the essential oil showed activity considered weak, although they inhibited the growth of microorganisms. About the antioxidant potential, the ethanolic and aqueous extracts exhibited a scavenging index exceeding 90%, while the essential oil didn´t show significant antioxidant activity. Regarding the phytochemical composition, the largest class of volatile compounds identified in the essential oil of P. cattleianum included the following terpenic hydrocarbons: α-copaene (22%); eucalyptol (15%), δ-cadinene (9.63%) and α-selinene (6.5%). The phytochemical screening of extracts showed the presence of tannins, flavonoids, and triterpenoids for aqueous and ethanolic extracts. The extracts and essential oils inhibit the growth of microrganisms and plant extracts showed significant antioxidant activity. Also, the phytochemical characterization of the essential oil showed the presence of compounds interest commercial, as well as extracts showed the presence of important classes and compounds with biological activities.Keywords: Psidium cattleianum, antimicrobial action, microdilution, GC-MS, antioxidant activity. Atividade antimicrobiana e antioxidante do óleo essencial e diferentes extratos vegetais de Psidium cattleianum Sabine ResumoOs objetivos do trabalho foram determinar: as atividades antimicrobiana e antioxidante do óleo essencial e dos extratos vegetais aquoso e etanólico de Psidium cattleianum Sabine; a composição química do óleo essencial P. cattleianum e a triagem fitoquímica dos extratos vegetais aquoso e etanólico da mesma planta. Quanto à atividade antimicrobiana, o extrato etanólico apresentou atividade antimicrobiana moderada frente as bactérias K. pneumonieae e S. epidermidis, enquanto frente aos demais micro-organismos apresentou atividade considerada fraca. O extrato aquoso e o óleo essencial apresentaram atividade considerada fraca, embora tenham inibido o crescimento dos micro-organismos. Em relação ao potencial antioxidante, os extratos etanólico e aquoso apresentaram índice de sequestro superior a 90%, enquanto o óleo essencial não apresentou atividade antioxidante significativa. Para a composição fitoquímica, a maior classe de compostos voláteis identificados no óleo essencial de P. cattleianum foram os hidrocarbonetos terpênicos, sendo eles: α-copaeno (22%), eucaliptol (15%), δ-cadineno (9,63%) e α-selineno (6,5%). Na triagem fitoquímica dos extratos verificou-se a presença de taninos, flavonóides e triterpenói...

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Section: Introductionmentioning

confidence: 99%

Antimicrobial and antioxidant activity of essential oil and different plant extracts of Psidium cattleianum Sabine

et al. 2016

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“…This use tends to grow over the years, both in developed and developing countries (Veiga, Pinto, Maciel, 2005;Viegas, Bolzani, Barreiro, 2006;WHO, 2004).…”

Section: Introductionmentioning

confidence: 99%

Determination of metals in medicinal plants highly consumed in Brazil

Leal

Prado

Gomes

et al. 2013

Braz. J. Pharm. Sci.

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In this work, samples of the medicinal plants: Boldo (Peumus boldus), Castanha da Índia (Aesculus hippocastanum), Chá Verde (Camelia sinensis), Erva Cidreira (Melissa officinalis), Espinheira Santa (Maytenus ilicifolia), Guaraná (Paullinia cupana), Maracujá (Passiflora sp.), Mulungu (Erythrina velutina), Sene (Cassia angustifolia) and Valeriana (Valeriana officinalis) were evaluated BY using the Neutron Activation Analysis technique (NAA-k 0 ) in order to determine the levels of metals and other chemical contaminants. The results showed the presence of non essential elements to the human body. The diversity of chemical impurities found even at low concentration levels, considering the potential for chronic toxicity of these elements, reinforces the need to improve the implementation of good practices by growers and traders, and the hypothesis of lack of quality control in plant products. (AAN-k 0 ), a fim de se determinar os teores de metais e outros elementos químicos contaminantes. Os resultados revelaram a presença de elementos não essenciais ao organismo humano. A diversidade de impurezas químicas encontradas, mesmo em níveis de baixa concentração, considerando o potencial de toxicidade crônica desses elementos, reforça a necessidade de melhorias na aplicação de boas práticas pelos produtores e comerciantes e a hipótese de falta de controle de qualidade nos produtos vegetais.Unitermos: Análise por ativação neutrônica/análise quantitativa. Plantas medicinais. Metais/determinação em plantas medicinais. Contaminantes químicos/determinação em plantas medicinais. Produtos vegetais/ controle de qualidade.

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“…Further acquaintance with different ethnic groups has contributed to the development of research on natural products, to the increase in knowledge about the close relationship between the chemical structure of a certain compound and its biological properties, and to the understanding of the animal/ insect-plant interrelation (8). For these reasons, medicinal plants are important substances for the study of their traditional uses through the verification of pharmacological effects and can be natural composite sources that act as new anti-infectious agents.…”

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confidence: 99%

Antibacterial activity of medicinal plant extracts

Ushimaru¹,

Silva²,

Stasi³

et al. 2007

Braz. J. Microbiol.

105

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The present study aimed at evaluating the in vitro antimicrobial activity of methanolic extracts of some medicinal plants against Escherichia coli, Salmonella Typhimurium, Staphylococcus aureus and Enterococcus sp. The methanolic extract of Caryophyllus aromaticus presented the highest anti-S. aureus activity and was effective against all bacterial strains tested. 3815-3744. E-mail: ary@ibb.unesp.br Further acquaintance with different ethnic groups has contributed to the development of research on natural products, to the increase in knowledge about the close relationship between the chemical structure of a certain compound and its biological properties, and to the understanding of the animal/ insect-plant interrelation (8). For these reasons, medicinal plants are important substances for the study of their traditional uses through the verification of pharmacological effects and can be natural composite sources that act as new anti-infectious agents.The present study aimed at evaluating the in vitro antimicrobial activity of plant (Allium sativum, Zingiber officinale, Caryophyllus aromaticus, Cymbopogon citratus, Mikania glomerata and Psidium guajava) extracts against Gram-positive and Gram-negative bacterial strains isolated from human infections. The determined plant parts (200g) were ground, extracted with 70% methanol and filtered after 48hs. The plant residue was re-extracted by adding 70% methanol and filtered again after 48hs. Such procedure was repeated every 72hs, completing three filtration processes. The filtrate was concentrated on a rotary evaporator at 45ºC for methanol elimination, and the extracts were kept in sterile bottles under refrigerated conditions until use. The dry weight of the extracts was obtained by allowing the solvent to evaporate and was used to determine concentration in mg/mL. (Methodology based on Betoni et al. (3); Table 1).Microbial susceptibility assays using the agar dilution (Mueller-Hinton Agar) method (%v/v and corresponding mg/ mL values) and the Minimal Inhibitory Concentration (MIC) were carried out for fifteen Salmonella Typhimurium, S. aureus, Enterococcus sp and E. coli strains plus one ATCC strain of each bacterium. Overnight cultures (37ºC) in Brain Heart

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Os produtos naturais e a química medicinal moderna

Cited by 173 publications

References 36 publications

Antimicrobial and antioxidant activity of essential oil and different plant extracts of Psidium cattleianum Sabine

Antimicrobial and antioxidant activity of essential oil and different plant extracts of Psidium cattleianum Sabine

Determination of metals in medicinal plants highly consumed in Brazil

Antibacterial activity of medicinal plant extracts

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