Antimicrobial and antioxidant activity of essential oil and different plant extracts of Psidium cattleianum Sabine

Scur, Mayara Camila; Pinto, Fabiana Gisele da Silva; Pandini, Jessica Angela; Costa, Willian Ferreira da; Leite, Camila Wihby; Temponi, Lívia Godinho

doi:10.1590/1519-6984.13714

Cited by 69 publications

(53 citation statements)

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“…The effectiveness of S. hispida can be justified due important to secondary metabolites, such as flavonoids and tannins, which have already demonstrated their antiinflammatory and antioxidant properties (Bahramsoltani et al, 2014;Scur et al, 2016). Published data demonstrate that pharmacological activity of S. hispida species reduces the inflammatory process induced by crude venom injection of Bothrops moojeni (Dourado et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Wound-Healing potential of Sebastiania hispida (Mart.) Pax (Euphorbiaceae) ointment compared to low power laser in rats

et al. 2016

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Impaired wound healing represents a serious complication in some pathologies and the use of plant extracts has proved to improve tissue repair. The objectives of this study were to evaluate the healing potential of the ointment of Sebastiana hispida compared with Aluminum-Gallium Indium-Phosphide Laser (InGaAlP) in surgically induced wounds in rats and to perform the phytochemical analysis. The phytochemical analysis was performed in the classic way and also by HPLC. A controlled study was developed with 80 rats (200-250 g) in which a linear excision was performed in the dorsal region after shaving, measuring 2 cm × 1 cm (epidermis and dermis) exposing the muscle fascia. The rats were randomly divided into four groups of twenty animals each. The experimental groups (n = 5) were G1 (Saline); G2 (crude methanol plant extract 2% + Carbopol Gel 98%); G3 (crude methanol plant extract 2% + lanolin/vaseline) and G4 (laser). The incision healing processes were monitored during 3, 7, 14 and until 21 days after excision. The histologic parameters evaluated were Collagen fiber types, microscopic examination and neovascularization. There was a significant increase in the deposition of collagen fibers, as evidenced by a better organized epithelial tissue, keratinized and showing greater proliferation of new blood vessels in the inflammatory phase in the group treated with both the extract and laser. The results were correlated to the phenolic derivatives found after qualitative and quantitative analysis. These compounds were considered responsible for the healing process. The topical treatment with S. hispida leaves, in the two different formulations, was more effective than the application of the laser (Ingan ALP) 660 nm in the model used.Keywords: laser therapy, tissue repair, inflammatory cells, medicinal plants. Potencial cicatrizante da pomada de Sebastiania hispida (Mart.) Pax (Euphorbiaceae) comparado ao laser de baixa potência ResumoA cicatrização deficiente representa uma complicação grave em algumas patologias e o uso de extratos de plantas tem demonstrado melhora no processo de reparação tecidual. O objetivo deste estudo foi avaliar o potencial cicatrizante da pomada de Sebastiania hispida comparado ao Laser Indio Phosphide-Gallium-Aluminum (InGaAlP) em feridas cutâneas induzidas cirurgicamente em ratos e realizar analise fitoquímica. A análise fitoquímica foi via clássica e por CLAE. O experimento foi desenvolvido com 80 ratos (200-250 g), divididos aleatoriamente em quatro grupos (n = 5): G1 (salina); G2 (extrato bruto metanólico 2% + Carbopol Gel 98%); G3 (extrato bruto metanólico 2% + lanolina/ vaselina) e G4 (laser). Após a tricotomia da região dorsal realizou uma excisão linear, medindo 2 cm × 1 cm (epiderme e derme), expondo a fáscia muscular. Em sequência os tratamentos e o monitoramento do processo de cicatrização das feridas cirúrgicas ocorreu nos tempos de: 3, 7, 14 e até 21 dias após a excisão. Os parâmetros histológicos avaliadosBraz.

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Section: Discussionmentioning

confidence: 99%

Wound-Healing potential of Sebastiania hispida (Mart.) Pax (Euphorbiaceae) ointment compared to low power laser in rats

et al. 2016

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“…In Brazil, there are six genera and about 100 species (Lorenzi and Matos, 2008). The members of this family have a wide diversity of chemical compounds, including limonoids, triterpenes, steroids, diterpenes, sesquiterpenes and coumarins (Cortez et al, 2000;Lago et al, 2000Lago et al, , 2002Soares et al, 2012;Scur et al, 2016). Limonoids are the most abundant compounds and, probably, the largest representatives of the class of terpenes with insecticidal activity (Luo et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Chemical composition, antimicrobial and antioxidant potential of the essential oil of Guarea kunthiana A. Juss

et al. 2017

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The essential oils are extracted from plant compounds and can present activities antimicrobial and antioxidant properties. The goals of the present study were: (a) to determine the chemical composition of the essential oil of Guarea kunthiana A. Juss using the method of gas chromatography coupled to mass spectrometry (GC-MS); (b) to evaluate the antimicrobial potential of this oil using the broth microdilution method against different microorganisms: five Gram-negative bacteria, four Gram-positive bacteria and a yeast and (c) to determine the antioxidant activity of the oil using the DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical assay. The GC-MS analyses allowed identifying 13 constituents, representing 96.52% of the essencial oil composition. The main compounds identified were α-zingiberene (34.48%), β-sesquiphellandrene (22.90%), and α-curcumene (16.17%). With respect to the antimicrobial activity, the essential oil was effective against all the microorganisms tested, except for the bacteria E. coli and K. pneumoniae, which were resistant to the action of the oil. From a general point of view, Gram-positive bacteria were more susceptible to the action of the essential oil than Gram-negative bacteria. The essential oil exhibited antioxidant potential.Keywords: Guarea kunthiana, essential oil, chemical composition, antimicrobial activity, antioxidant. Composição química, potencial antimicrobiano e antioxidante do óleo essencial de Guarea kunthiana A. Juss ResumoOs óleos essenciais são compostos extraídos de plantas e podem apresentar propriedades antimicrobianas e antioxidantes. O objetivo deste trabalho foi (a) determinar a composição química do óleo essencial de Guarea kunthiana A. Juss pelo método de cromatografia gasosa acoplada à espectrometria de massas (CG-EM); (b) avaliar o potencial antimicrobiano deste óleo pelo método de microdiluição em caldo frente a diferentes micro-organismos, sendo cinco bactérias Gram-negativas, quatro Gram-positivas uma levedura e (c) por fim, determinar a atividade antioxidante do óleo pelo método de captura do radical livre 2,2-difenil-1-picril hidrazil (DPPH). As análises de CG-EM resultaram na identificação de 13 constituintes, representando 96,52% da composição do óleo essencial. Os principais compostos identificados foram α-Zingibereno (34,48%), β-Sesquifelandreno (22,90%) e α-Curcumeno (16,17%). Em relação à atividade antimicrobiana, o óleo essencial foi efetivo frente a todos os micro-organismos testados exceto para as bactérias E. coli e K. pneumoniae, as quais se apresentaram resistentes à ação do óleo. Em geral, as bactérias Gram-positivas foram mais suscetíveis à ação do óleo essencial em relação às Gram-negativas. O óleo essencial apresentou potencial.Palavras-chave: Guarea kunthiana, óleo essencial, composição química, atividade antimicrobiana, antioxidante.

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“…Currently, there is a trend toward the use of natural substances and medicinal plants [19,20] and within this context, the results presented in previous studies with Psidium cattleianum aroused interest in its use as intracanal irrigant solution during endodontic treatment. Psidium cattleianum seems to be promising as intracanal medication during endodontic treatment [21][22][23][24][25][26]. Aqueous and ethanol extracts of Psidium cattleianum have shown remarkable antibacterial activity against oral microbiota, anti-inflammatory and potential anticariogenic effects, and tissue biocompatibility [22][23][24]26].…”

Section: Introductionmentioning

confidence: 99%

“…Psidium cattleianum seems to be promising as intracanal medication during endodontic treatment [21][22][23][24][25][26]. Aqueous and ethanol extracts of Psidium cattleianum have shown remarkable antibacterial activity against oral microbiota, anti-inflammatory and potential anticariogenic effects, and tissue biocompatibility [22][23][24]26]. However, determining the use and clinical application of this extract requires testing for cytotoxicity, sensitization [25], anti-inflammatory and antimicrobial activities [21,22,24,26], among other issues.…”

Section: Introductionmentioning

confidence: 99%

Ethanolic Extract of Psidium cattleianum as Intracanal Irrigation: An In vitro Study of Cell Viability

Martins¹

2017

J. Dent. Sci. Ther

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The aim of this study was to evaluate the ethanolic extract of Psidium cattleianum biocompatibility by structural and functional cell viability maintenance. Cell viability was analyzed after 1 h, 3 h, 6 h, 10 h and 24 h of incubation by Exclusion Method with trypan blue and MTT assay, using human mononuclear cells (PBMC) and human periodontal ligament (PDL) cells in culture. Positive control used was RPMI cell culture medium and negative control was ethanol 80%. The obtained data were subjected to statistical analysis at a significance level of 5%. By trypan blue assay, ethanolic extract presented a homogeneous performance of PBMC from the 1 h, with average viability between 30 and 50% (p>0.05). By MTT assay, the results showed the efficacy of the ethanolic extract of Psidium cattleianum in maintaining the functional viability of the periodontal ligament cells to 10 h (p>0.05), presenting values greater than the RPMI control. In both methods, it can be observed that the extract properties can neutralize the cytotoxic effect of its diluent ethanol 80%, which showed average viability nearly zero (p <0.05). Thus, biocompatibility by structural and functional cell viability maintenance was considered acceptable to ethanolic extract of Psidium cattleianum and further studies should be performed to indicate its use as an alternative to irrigation solution traditionally used in everyday practice.

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Antimicrobial and antioxidant activity of essential oil and different plant extracts of Psidium cattleianum Sabine

Cited by 69 publications

References 32 publications

Wound-Healing potential of Sebastiania hispida (Mart.) Pax (Euphorbiaceae) ointment compared to low power laser in rats

Wound-Healing potential of Sebastiania hispida (Mart.) Pax (Euphorbiaceae) ointment compared to low power laser in rats

Chemical composition, antimicrobial and antioxidant potential of the essential oil of Guarea kunthiana A. Juss

Ethanolic Extract of Psidium cattleianum as Intracanal Irrigation: An In vitro Study of Cell Viability

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