Spectrophotometric determination of cefaclor in pharmaceutical preparations

Ivama, Viviane M.; Rodrigues, Letícia Norma Carpentieri; Guaratini, Cláudia C. I.; Zanoni, María Valnice Boldrin

doi:10.1590/s0100-40421999000200011

Cited by 22 publications

(13 citation statements)

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“…The limit of quantification is defined as the lower limit for precise quantitative measurement as opposed to qualitative detection. The value of Y B + 10S B was used for this calculation 20 . The formula was applied in a similar way as for the LOD.…”

Section: Resultsmentioning

confidence: 99%

Spectrophotmetric Determination of Cefadroxil in Bulk and Dosage Form Using Sodium Hydroxide

Shantier¹,

Gadkariem²,

Ibrahim³

et al. 2010

Journal of Chemistry

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A simple spectrophotometric method was developed for the determination of cefadroxil in pure bulk and in capsules forms. The method is based on a direct reaction between cefadroxil and sodium hydroxide (1 N). A product with λmaxat 342 nm and molar absorptivity of 7.9x103L mol-1cm-1is formed after heating cefadroxil with sodium hydroxide (1 N) for 30 minutes. The absorbance-concentration plot was rectilinear over the range 5-25 μg/mL with correlation coefficient values not less than 0.999. The detection limit (LOD) and quantification limit (LOQ) were 0.693 μg/mL and 2.31 μg/mL. The method was validated using the BP liquid chromatographic method for cefadroxil assay. The results obtained by the developed method for the capsules dosage form were statistically compared with those of the BP liquid chromatography method and evaluated at 95% confidence limits.

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Section: Resultsmentioning

confidence: 99%

Spectrophotmetric Determination of Cefadroxil in Bulk and Dosage Form Using Sodium Hydroxide

Shantier¹,

Gadkariem²,

Ibrahim³

et al. 2010

Journal of Chemistry

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“…2. Chemical structures of degradation products of cefaclor (1.0 mmol/l) formed at pH 11.0 and its spectrum [8].…”

Section: Direct Spectrophotometrymentioning

confidence: 99%

Spectrophotometric Methods as Solutions to Pharmaceutical Analysis of β-Lactam Antibiotics

Cielecka‐Piontek¹,

Zalewski²,

Krause³

et al. 2012

Macro to Nano Spectroscopy

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“…Most of the reported methods involve the cleavage of the β-lactam moiety of the cephalosporin structure. These methods include spectrophotometric [2][3][4][5][6] spectrofluorimetric [7][8][9][10]. and electrochemical methods [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Kinetic spectrophotometric determination of certain cephalosporins using iodate/iodide mixture

El-Shaboury

Mohamed²,

Saleh³

et al. 2010

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A simple, precise and accurate kinetic spectrophotometric method for determination of cefradine anhydrous, cefaclor monohydrate, cefadroxil monohydrate, cefalexin anhydrous and cefixime in bulk and in pharmaceutical formulations has been developed. The method based on a kinetic investigation of the reaction of the free carboxylic acid group of the drug with a mixture of potassium iodate and potassium iodide at room temperature to form yellow coloured triiodide ions. The reaction was followed up spectrophotometrically by measuring the increase in absorbance at 352 nm as a function of time. The initial rate, fixed time, variable time and rate-constant methods were adopted for constructing the calibration curves but fixed time method has been found to be more applicable. The analytical performance of the method, in terms of accuracy and precision, was statistically validated; the results were satisfactory. The method has been successfully applied to the determination of the studied drugs in commercial pharmaceutical formulations. Statistical comparison of the results with a well established reported method showed excellent agreement and proved that there is no significant difference in the accuracy and precision.

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Spectrophotometric determination of cefaclor in pharmaceutical preparations

Cited by 22 publications

References 0 publications

Spectrophotmetric Determination of Cefadroxil in Bulk and Dosage Form Using Sodium Hydroxide

Spectrophotmetric Determination of Cefadroxil in Bulk and Dosage Form Using Sodium Hydroxide

Spectrophotometric Methods as Solutions to Pharmaceutical Analysis of β-Lactam Antibiotics

Kinetic spectrophotometric determination of certain cephalosporins using iodate/iodide mixture

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