Tomografia computadorizada na avaliação da distribuição do tecido adiposo abdominal de ratos alimentados com rações hiperlipídicas após desnutrição neonatal

Costa, Carlos Alberto Soares da; Alves, Erika Gomes; Gonzalez, Gabriele Paula; Barbosa, Thais Barcellos Côrtez; Lima, Veronica Demarco; Nascimento, Renata Cristina Rezende Macedo do; Monteiro, Alexandra; Moura, Egberto Gaspar de; Saba, Celly Cristina Alves do Nascimento

doi:10.1590/s0100-39842007000500011

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…Com isso, as dislipidemias e a hiperglicemia, causadas pela obesidade e pela inatividade física, estão fortemente associadas com o risco de maior probabilidade para desenvolver doenças cardiovasculares, sendo que as gorduras viscerais estão associadas com efeitos negativos à saúde, independentemente da quantidade de gordura corporal, isto é, mesmo o indivíduo apresentando um Índice de Massa Corporal (IMC) normal, ainda há riscos de arteriosclerose (CASTRO et al, 2004;COSTA et al, 2007;ANJANA et al, 2004).…”

Section: Introductionunclassified

Influência das Dietas Hipercalóricas sobre os Parâmetros de Obesidade, Dislipidemia e Hiperglicemia em Ratos

et al. 2015

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RESUMO:Este estudo teve como objetivo induzir dietas hipercalóricas em ratos para promover a obesidade e verificar seus níveis bioquímicos, relacionando-os com ratos alimentados por dieta padrão. Foram utilizados 30 ratos, pesando entre 250 e 300 g. Os ratos foram divididos em dois grupos: Dieta Padrão (SD) e Dieta Cafeteria (CD). Após 30 dias, os grupos foram divididos em: SD, Dieta Plus (PD) e CD. Em 30 e 60 dias, realizaram-se as dosagens bioquímicas. Os animais foram pesados, medidos e realizaram-se os Índices de Lee e a análise macroscópica da gordura visceral. Os valores de peso, circunferência, tamanho e Índice de Lee, aumentaram nos animais da PD em 30 e 60 dias de dieta. Os parâmetros bioquímicos em 30 dias aumentaram os níveis de colesterol total e HDL do grupo SD em relação à PD e CD. Em 60 dias o colesterol total e HDL sofreram uma diminuição. Os níveis de glicose em 30 dias aumentaram em relação aos grupos da PD e CD. Na análise macroscópica da gordura visceral, o grupo PD apresentou alteração visível em relação à SD. Ao induzir dietas em animais, estes apresentaram respostas diferentes através do metabolismo e do tempo de indução da dieta. PALAVRAS-CHAVE:Dislipidemias; Hiperglicemia; Obesidade; Ratos. INFLUENCE OF HYPERCALORIC DIETS ON THE PARAMETERS OF OBESIT Y, DYSLIPIDEMIA AND HYPERGLYCEMIA IN RATSABSTRACT: Hypercaloric diets were induced in rats to trigger obesity and analyze their biochemical levels. The rats were then compared with others fed on standard rations. Thirty rats, weighing 250-300 g, were used and divided into two groups: Standard Diet (SD) and Cafeteria Diet (CD). After 30 days, the groups were divided into SD, Diet Plus (PD) and CD; and biochemical tests were undertaken after 30 and 60 days. The animals were weighed, measured and the Lee Index and the microscopic analysis of visceral fat were taken. Weight, circumference, size and Lee Index increased in PD animals after 30 and 60 days of diet. In 30 days the chemical parameters increased total cholesterol and HDL levels of group SD when compared to PD and CD. Total cholesterol and HDL decreased after 60 days. Glucose levels increased after 30 days when compared to groups PD and CD. Group PD had a clear change in the microscopic analysis of visceral fat when compared to SD. Induced diet in animals had different reactions due to metabolism and induction time.

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Section: Introductionunclassified

Influência das Dietas Hipercalóricas sobre os Parâmetros de Obesidade, Dislipidemia e Hiperglicemia em Ratos

et al. 2015

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Diet containing low n-6/n-3 polyunsaturated fatty acids ratio, provided by canola oil, alters body composition and bone quality in young rats

et al. 2011

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Abdominal adiposity, insulin and bone quality in young male rats fed a high-fat diet containing soybean or canola oil

Costa

Carlos²,

Santos³

et al. 2011

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OBJECTIVES:A low ratio of omega-6/omega-3 polyunsaturated fatty acids is associated with healthy bone properties. However, fatty diets can induce obesity. Our objective was to evaluate intra-abdominal adiposity, insulin, and bone growth in rats fed a high-fat diet containing low ratios of omega-6/omega-3 provided in canola oil.METHODS:After weaning, rats were grouped and fed either a control diet (7S), a high-fat diet containing soybean oil (19S) or a high-fat diet of canola oil (19C) until they were 60 days old. Differences were considered to be significant if p<0.05.RESULTS:After 60 days, the 19S and 19C groups showed more energy intake, body density growth and intra-abdominal fat mass. However, the 19S group had a higher area (200%) and a lower number (44%) of adipocytes, while the 7S and 19C groups did not differ. The serum concentrations of glucose and insulin and the insulin resistance index were significantly increased in the 19C group (15%, 56%, and 78%, respectively) compared to the 7S group. Bone measurements of the 19S and 19C groups showed a higher femur mass (25%) and a higher lumbar vertebrae mass (11%) and length (5%). Computed tomography analysis revealed more radiodensity in the proximal femoral epiphysis and lumbar vertebrae of 19C group compared to the 7S and 19S groups.CONCLUSIONS:Our results suggest that the amount and source of fat used in the diet after weaning increase body growth and fat depots and affect insulin resistance and, consequently, bone health.

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Tomografia computadorizada na avaliação da distribuição do tecido adiposo abdominal de ratos alimentados com rações hiperlipídicas após desnutrição neonatal

Cited by 3 publications

References 26 publications

Influência das Dietas Hipercalóricas sobre os Parâmetros de Obesidade, Dislipidemia e Hiperglicemia em Ratos

Influência das Dietas Hipercalóricas sobre os Parâmetros de Obesidade, Dislipidemia e Hiperglicemia em Ratos

Diet containing low n-6/n-3 polyunsaturated fatty acids ratio, provided by canola oil, alters body composition and bone quality in young rats

Abdominal adiposity, insulin and bone quality in young male rats fed a high-fat diet containing soybean or canola oil

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