Nuevos fármacos inspirados en Annonáceas

Cortés, Diego; Moreno, Laura; Párraga, Javier; Galán, Abraham; Cabedo, Nuria

doi:10.1590/s0100-29452014000500003

Cited by 6 publications

(5 citation statements)

References 50 publications

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“…These ALKs are involved in major behavioral disorders such as schizophrenia, Huntington's disease, attention deficit hyperactivity disorder, and Parkinson's disease. Precisely, alkaloids with (R)-apomorphine groups, aporfin semi-synthesized from morphine, have been used in the clinic for treating Parkinson's disease [10][11][12]. Likewise, it has been demonstrated that these alkaloids have an affinity for 5-HT1A receptors in vitro and participate in the biosynthesis of dopamine.…”

Section: Introductionmentioning

confidence: 99%

Extraction of Alkaloids Using Ultrasound from Pulp and By-Products of Soursop Fruit (Annona muricata L.)

et al. 2020

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The main goal of this work was to measure the total alkaloid content (TALC) from pulp, peel, seed, and columella of soursop fruit (Annona muricata L.) by ultrasound-assisted extraction (UAE) and to obtain the best conditions of the UAE with the response surface methodology (RSM). We evaluated the effect of amplitude (40%, 70%, and 100%), time (5, 10, and 15 min) and pulse-cycles (0.4, 0.7, and 1 s) and compared the best UAE conditions of alkaloids with a conventional extraction (maceration). The structural characterization of the raw material with the highest TALC was developed using nuclear magnetic resonance (NMR) techniques [1H, 13C, heteronuclear single quantum correlation (HSQC), heteronuclear multiple bond correlation (HMBC), and homonuclear correlation spectroscopy (COSY)]. According to the RSM, the best conditions in the UAE for extracting alkaloids varied depending on the type of plant tissue. It took 5 min with an amplitude of 70% and pulse-cycles of 1, 0.4, and 1 s, respectively, to extract the highest TALC in peel, seed, and columella while the optimal conditions for extracting the largest amount of alkaloids from the pulp were obtained at 5 min in UAE with pulse-cycles of 0.55 s and 100% amplitude. The TALC was highest in the peel (7.48 mg/g), which was followed by the seed (2.31 mg/g), the pulp (1.20 mg/g), and the columella (0.79 mg/g) and was positively correlated (R2 = 0.98–0.88) with the predicted values. In addition, the extraction alkaloids from the peel, pulp, seed, and columella using the UAE was 56.31, 5.45, 3.06, and 2.96 times higher, respectively, than the extraction by maceration. The alkaloids identified in the peel have not been reported and were nornuciferin, assimilobin, anonaine, and isolaureline. This study showed that the soursop fruit peel can be a source of alkaloids and that UAE has an important potential for extracting these compounds.

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Section: Introductionmentioning

confidence: 99%

Extraction of Alkaloids Using Ultrasound from Pulp and By-Products of Soursop Fruit (Annona muricata L.)

et al. 2020

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“…Galls were dried and reduced into powder (100 g) separated into 3; Soxhlet extraction technique was adopted to get crude extracts using methanol as solvent. The extract obtained was concentrated in a rotary evaporator at low pressure and temperature to give crude methanol extracts, tannins were precipitated by ammoniac to give 48 g than the residue was extracted by chloroform according to the Stas Otto Method (Cortes, 2019). TLC was carried (DCM-MeOH-H2O, 77:13:10) to give gallic acid Rutin and caffeoylquinic acid, these compounds were determined using UV visible and Infrared spectroscopy (Jahangirian, 2011) using the spectral database (Bio-Rad) as well as a direct comparison of TLC with authentic samples (Sigma) available in our laboratory.…”

Section: Methodsmentioning

confidence: 99%

In vitro antimitotic activity of gall extract of Pistacia terebinthus

Nazim¹,

Ismail²,

Houari³

et al. 2020

Current Perspectives on Medicinal and Aromatic Plants (CUPMAP)

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Pistacia terebinthus L. -turpentine tree -is a perennial flowering plant in the Mediterranean region, some aphids species induce the formation of galls in Pistacia terebinthus formerly called Carobs of Judea whose tannin content equals 60%, used in traditional medicine as a stimulant, diuretic, astringent for the treatment of asthma and other respiratory and urological affections. In the present study, the antimitotic activity of Pistacia terebinthus galls was evaluated using meristematic cells of Allium cepa roots assay our results reveal that the methanolic extract decreased the root length and dividing cell number significantly after 96 h and compared to control (p< 0.05) the mitotic index of extract at the concentration 4 mg/ml was 31% and has significant activity near to the standard methotrexate. Overall, the methanol extract of P. terebinthus galls revealed the presence of the phytochemical's compounds such as gallic acid, caffeoylquinic acid, which affect plant mitosis and can be used as an antimitotic drug.

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“…They are also reported as active compounds of annonaceous, isoquinolic alkaloids, and phenolic compounds and, to a lesser extent, cycle peptides, vitamins, carotenoids, amides, carbohydrates, glycosides and volatile compounds (González, 2005;Cortes et al, 2014;Moghadamtousi et al, 2015;Ma et al, 2017;Coria et al, 2018). According to the studies, Annonaceae leaves are enriched with different types of isoquinoline alkaloids (Fig.…”

Section: Analysis Of Trends In Scientific Publications On Botanical Biopesticidesmentioning

confidence: 99%

Botanical biopesticides: research and development trends, a focus on the Annonaceae family

Giraldo-Rivera

Álvarez

2019

Rev. Colomb. Cienc. Hortic.

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This document analyzed research and development trends related to chemical, biological and economical biopesticides based on plant extracts, with emphasis on the Annonaceae family. A systematic review of the literature between 1947 and 2018 was done with an advance search equation in a specialized data base. This paper contains the development of plant bio pesticides, their modes of action, the more prominent families according to their bioactivity and the secondary metabolites that exert control over pests that are significant in agriculture and public health. The dynamics of publications, at the national and international levels, were identified, along with the countries that lead research, patents assigned in the last 20 years, market trends and bio pesticide regulation. The reviewed research is relevant to bioprospecting plant extracts with potential insecticidal activity and to the subsequent development of biocides using botanical extracts; the Annonaceae family is promising.

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Nuevos fármacos inspirados en Annonáceas

Cited by 6 publications

References 50 publications

Extraction of Alkaloids Using Ultrasound from Pulp and By-Products of Soursop Fruit (Annona muricata L.)

Extraction of Alkaloids Using Ultrasound from Pulp and By-Products of Soursop Fruit (Annona muricata L.)

In vitro antimitotic activity of gall extract of Pistacia terebinthus

Botanical biopesticides: research and development trends, a focus on the Annonaceae family

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