Declining prevalence of hepatitis A virus antibodies among children from low socioeconomic groups reinforces the need for the implementation of hepatitis A vaccination in Brazil

Vitral, Cláudia Lamarca; Ospina, Fidel Leonardo Navarro; Oliveira, Solange Artimos de; Melgaço, Juliana Gil; Cruz, Oswaldo Gonçalves; Paula, Vanessa Salete de; Luz, Sérgio Bessa; Freire, Marcos da Silva; Gaspar, Luciane P.; Amado, Luciane Almeida; Engstrom, Elyne Montenegro; Fortes, Camila Dufrayer Fanzeres Monteiro; Souza, Tayla Coleta de; Dias, Marisa Nishitani; Gaspar, Ana; Souto, Francisco José Dutra

doi:10.1590/s0074-02762012000500012

Cited by 31 publications

(33 citation statements)

References 29 publications

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“…In Brazil, seroprevalence studies conducted recently mainly in urban areas, showed a consistent decrease of the incidence rates in childhood 4,5,6,7,8,9,10 . Decrease in HAV circulation 8,9,11,12 as well as a progressive decline in fatal cases related to HAV infection in all Brazilian regions 8 have also begun to be noticed.…”

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confidence: 84%

Hepatitis A seroprevalence in public school children in Campos dos Goytacazes, Rio de Janeiro State, Brazil, prior to the introduction of the hepatitis A universal childhood vaccination

et al. 2016

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This cross-sectional study was carried out between August 2011 and July 2012 in the city of Campos dos Goytacazes in Rio de Janeiro State, Brazil. Dried blood spot samples were collected on filter paper from 919 individuals between the ages of 1 and 19 and were tested for antibodies against the hepatitis A virus (anti-HAV). The total prevalence was 20.7%, while 94.7% of children under the age of 5 were found to be susceptible to HAV infection. The prevalence of anti-HAV increased with age, reaching 33.3% among individuals aged between 15 and 19, thereby indicating that this municipality has a low level of endemicity for hepatitis A. Age, non-white skin color, accustomed to swimming in the river and more than five people living at home were the factors that were associated with an increase in the chance of a positive anti-HAV result. Mother's education level (secondary or tertiary) was considered a protective factor for HAV infection. The data obtained showed that a large proportion of the children from Campos dos Goytacazes were at risk of HAV infection, which should be minimized with the introduction of the vaccination program against hepatitis A that was launched in the municipality in 2011.

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confidence: 84%

Hepatitis A seroprevalence in public school children in Campos dos Goytacazes, Rio de Janeiro State, Brazil, prior to the introduction of the hepatitis A universal childhood vaccination

et al. 2016

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“…Five municipalities were selected for the study. The defined geographical areas were urban (Cochabamba city), suburban (Tiquipaya and Punata), and rural (Vinto and Parotani) [27][28][29][30].…”

Section: Methodsmentioning

confidence: 99%

Prevalence of Immunity against Infection of Hepatitis A and Hepatitis B in Children Cochabamba, Bolivia

Mr¹,

Masuet-Aumatell²,

Ramon-Torrell³

et al. 2016

J Infect Dis Ther

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“…El estudio se hizo en la población rural de tres ciudades de Brasil: Río de Janeiro, Cuiabá y Manaos. La seroprevalencia en niños de 10 a 14 años de edad fue mayor del 50%, lo que indica una población de niños entre 1 y 4 años susceptibles a la infección por VHA (42). Estos resultados, similares a los hallados en el estudio hecho en 1999, son característi-cos de regiones de endemicidad intermedia.…”

Section: Epidemiologíaunclassified

“…Aunque la población rural tenía un bajo ingreso económico, sus viviendas contaban con buenos sistemas de disposición de aguas residuales y acceso a agua potable. Es importante aclarar que el estatus socioeconómico es una de las variables relacionadas con la prevalencia de VHA cuando describe directamente los niveles de sanidad y acceso a agua potable (42 …”

Section: Epidemiologíaunclassified

Infección por el virus de la hepatitis A: epidemiología y diversidad genética

Navas

Triana

2015

iatreia

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RESUMENLa infección por el virus de la hepatitis A es un problema global de salud pública. El virus está ampliamente distribuido y es la principal causa de hepatitis aguda de transmisión entérica en Latinoamérica. La partícula viral es estable en el medio ambiente y conserva su infectividad por varias semanas, lo que facilita su transmisión por agua y alimentos contaminados. Mundialmente se han descrito distintos patrones epidemiológicos, que pueden cambiar en el tiempo al modificarse variables socioeconómicas en la población como las condiciones sanitarias básicas y la vacunación. Esto deja al descubierto nuevas poblaciones susceptibles a la infección. En Latinoamérica se ha descrito la circulación del genotipo I y los subgenotipos A y B, pero se requieren más investigaciones que aporten el conocimiento necesario para gestionar planes de prevención y control para la disminución mundial de la prevalencia de la infección. Para este artículo se hizo una revisión de la literatura en las bases de datos SciELO, PubMed y ScienceDirect bajo los términos de búsqueda "Virus de la hepatitis A", "Epidemiología", "Seroprevalencia" e "Infección". De los resultados obtenidos se incluyeron únicamente las publicaciones en inglés y español que describieran estudios epidemiológicos y moleculares de interés en Latinoamérica. PALABRAS CLAVEEpidemiología; Hepatitis; Salud Pública; Virus de la Hepatitis A SUMMARY Hepatitis A virus infection: Epidemiology and genetic diversityHepatitis A virus infection is a global public health problem. The virus has a wide range of distribution and it is the main cause of acute hepatitis transmitted by the enteric route in

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Declining prevalence of hepatitis A virus antibodies among children from low socioeconomic groups reinforces the need for the implementation of hepatitis A vaccination in Brazil

Cited by 31 publications

References 29 publications

Hepatitis A seroprevalence in public school children in Campos dos Goytacazes, Rio de Janeiro State, Brazil, prior to the introduction of the hepatitis A universal childhood vaccination

Hepatitis A seroprevalence in public school children in Campos dos Goytacazes, Rio de Janeiro State, Brazil, prior to the introduction of the hepatitis A universal childhood vaccination

Prevalence of Immunity against Infection of Hepatitis A and Hepatitis B in Children Cochabamba, Bolivia

Infección por el virus de la hepatitis A: epidemiología y diversidad genética

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