Biomphalaria alexandrina snails as immunogens against Schistosoma mansoni infection in mice

Hamed, Manal A.; Ali, Sanaa A.; Aly, Hanan F.; El-Rigal, Nagy Saba; Rizk, Maha Z.

doi:10.1590/s0074-02762010000700007

Cited by 7 publications

(3 citation statements)

References 38 publications

(30 reference statements)

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“…While, the present results illustrated significant elevation in AP activity post parasitic infection. This result is in concomitant with previous studies attributed this increment to lysosomes deflection and/or to destructive metabolism by the elevation of worm and eggs toxins since AP is considered as lysosomal enzyme and during infection all the lysosomal enzymes are enhanced due to destructive tissue initiated phagocytosis [44]. The present data also declared statistically increment in 5'-nucleotidase activity post infected mice with S. mansoni.…”

Section: Table 11supporting

confidence: 92%

In vitro produced glycoalkaloids from Solanum nigrum L. and evaluation of their potential role as antibilharziasis

Al-Ashaal¹,

Abduallah²,

Farghaly³

et al. 2017

APJTD

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Section: Table 11supporting

confidence: 92%

In vitro produced glycoalkaloids from Solanum nigrum L. and evaluation of their potential role as antibilharziasis

Al-Ashaal¹,

Abduallah²,

Farghaly³

et al. 2017

APJTD

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“…The recorded LDH increased more significantly in cancerous tissue associated with bilharzial infection than in malignant tissue. This increase in LDH was attributed to the enhancement of anaerobic glycolysis by Schistosoma toxins, suppression of pyruvate oxidative metabolism in mitochondria (where the mitochondrial enzymes were also affected) (Hamed et al 2010), marked disturbance in glycolytic pathways due to cancer complications and the overproduction and proliferation of cancer cells (Aly et al 2004).…”

Section: Resultsmentioning

confidence: 99%

Efficiency of diagnostic biomarkers among colonic schistosomiasis Egyptian patients

Hamed

Ahmed

Khaled

2011

Mem. Inst. Oswaldo Cruz

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“…In accordance to results herein Thangaraju et al (2009);Metwally et al (2011) reported that elevation of LDH activity in malignant and bilharzial colonic carcinoma can be used as an indicator for the stimulation of anaerobic pathways in cases of abnormal growth of human cancer cells. Aly et al (2004); Hamed et al (2010) reported that, the increase in LDH activity in bilharziasis can be related to the fact that the schistosoma parasite is producing lactate as a sole metabolic end, enhancement of anaerobic glycolysis by schistosoma toxins and suppression of pyruvate oxidative metabolism in mitochondria. Ross et al (2002) reported that the sequestered eggs in the intestinal mucosa and submucosa caused severe inflammatory reaction with cellular infiltration and consequent granuloma formation.…”

Section: Discussionmentioning

confidence: 99%

Inflammation, Oxidative Stress and L-Fucose as Indispensable Participants in Schistosomiasis-Associated Colonic Dysplasia

Soliman¹,

Keshk²,

Shoheib³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: Schistosomiasis is a parasitic disease causing chronic ill health in humans with a serious consequences for socio-economic development in tropical and subtropical regions. There is also evidence linking Schistosoma mansoni to colonic carcinoma occurrence. The aim of this study was to evaluate some inflammatory and oxidative stress biomarkers, as well as L-fucose as linkers between intestinal schistosomiasis and colonic dysplasia development in mice. Materials and Methods: This study was conducted upon 80 mice that were divided the control group (10 non infected mice) and infected group which was subdivided into 7 sub-groups (10 mice each) according to the time of sacrifaction in the post infection (p.i.) period, 10 mice being sacrificed every two weeks from 6 weeks p.i. to 18 weeks p.i. Tumor necrosis factor alpha (TNF-α), inducible nitric oxide synthase (iNOS), and pentraxin 3 (PTX3) levels were estimated by immunoassay. The L-fucose level, and thioredoxin reductase (TrxR) and lactate dehydrogenase (LDH) activities were also evaluated in colonic tissue. Results: The current study revealed statistically significant elevation in the studied biochemical markers especially at 16 and 18 weeks p.i. The results were confirmed by histopathological examination that revealed atypical architectural and cytological changes in the form of epithelial surface serration and nuclear hyper-chromatizia at 14, 16 and 18 weeks p.i. Conclusions: inflammation, oxidative stress and L-fucose together may form an important link between Schistosomal mansoni infection and colonic dysplasia and they can be new tools for prediction of colonic dysplasia development in experimental schistosomiasis.

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Biomphalaria alexandrina snails as immunogens against Schistosoma mansoni infection in mice

Cited by 7 publications

References 38 publications

In vitro produced glycoalkaloids from Solanum nigrum L. and evaluation of their potential role as antibilharziasis

In vitro produced glycoalkaloids from Solanum nigrum L. and evaluation of their potential role as antibilharziasis

Efficiency of diagnostic biomarkers among colonic schistosomiasis Egyptian patients

Inflammation, Oxidative Stress and L-Fucose as Indispensable Participants in Schistosomiasis-Associated Colonic Dysplasia

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