Studies on antimicrobial activity, in vitro, of Physalis angulata L. (Solanaceae) fraction and physalin B bringing out the importance of assay determination

Abstract

Complex physalin metabolites present in the capsules of the fruit of

Antimicrobial activity of the extracts and physalin D fromPhysalis alkekengiand evaluation of antioxidant potential of physalin D

“…Therefore, physalin D may be considered mainly responsible for the antibacterial activity. Similar to our results, Silva et al (2005) reported that physalin B and the fraction of physalins containing physalins B, D, F, and G inhibited different S. aureus strains and N. gonorrhoeae. Additionally, antimicrobial activity was described by several authors for methanol/ethanol or aqueous extracts of P. angulata and P. philadelphica against some Gram-positive and Gram-negative bacteria (Cáceres et al, 1991;Shim et al, 2002).…”

“…Previous studies have focused on the isolation and characterization of secondary metabolites, whereas it has been demonstrated that some of the extracts or active principles obtained from Physalis species have a broad spectrum of biological activities, including antileukemic, antitumor, immunomodulator, cytotoxic, antimycobacterial, antimicrobial, molluscicidal, antihepatoma, and antinociceptive activities in recent studies (Chiang et al, 1992a(Chiang et al, , 1992bJanuário et al, 2002;Shim et al, 2002;Su et al, 2002;Dos Santos et al, 2003;Soares et al, 2003;Wu et al, 2004;Choudhary et al, 2005;Lee & Houghton, 2005;Silva et al, 2005;Bastos et al, 2006;Magalhaes et al, 2006;Damu et al, 2007;Castro et al, 2008). It has been previously reported that the crude extract (i.e.…”

“…It has been previously reported that the crude extract (i.e. methanol/water, ethanol, or aqueous extract) or physalin-containing fractions obtained from P. angulata aerial parts possess antibacterial, antimycobacterial, and antigonorrheal activities, which can be related to the presence of physalin compounds of the extracts (Cáceres et al, 1995;Januário et al, 2002;Silva et al, 2005). Nevertheless, there is no information about antibacterial and antifungal properties of other Physalis species, including P. alkekengi.…”

Withanolides and Related Steroids

“…Among the physalins, physalin B (463) was active against S. aureus (several strains) and N. gonorrhoeae but not active against E. coli and P. aeruginosa (221). Physalin D (313), but not physalin B, was moderately active against Mycobacterium tuberculosis (222).…”

Actividad inmunoestimulante del extracto acuoso liofilizado de la planta entera de Physalis angulata L. en ratas albinas cepa Holtzman

“…En este estudio no se pudo identificar la presencia de fisalinas o witanolidos en el extracto acuoso, esto podría deberse a la naturaleza del extracto que hace difícil la detección de fisalinas, las cuales han sido observadas en extractos etanólicos y metanólicos (12,36,37) . Asimismo, cuando se realizó la caracterización química del extracto de Physalis angulata, el equipo CG-MS estaba calibrado para detectar solo moléculas con un peso molecular entre 50 a 500 g/mol y la fisalinas A, B,D,E,F y G, tienen un peso molecular mayor de 500 g/mol (38) , por lo cual era de esperarse que no se detecten.…”