Prevalence and genetic diversity of astroviruses in children with and without diarrhea in São Luís, Maranhão, Brazil

Gabbay, Yvone Benchimol; Luz, Cláudia Regina Nunes Eloi da; Costa, Ivete V.; Cavalcante-Pepino, Elielma L.; Sousa, Maisa S.; Oliveira, Krynssya K.; Wanzeller, Ana Lucia Monteiro; Mascarenhas, Joana D’Arc Pereira; Leite, José Paulo Gagliardi; Linhares, Alexandre C.

doi:10.1590/s0074-02762005000700004

Cited by 29 publications

(34 citation statements)

References 30 publications

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“…Astroviruses are considered important viral enteric pathogens in children with and without AG worldwide (Pennap et al 2002, Méndez-Toss et al 2004, Gabbay et al 2005. In this study, a higher detection rate of astrovirus in cases of AG (4.3%) was observed, as compared to non-diarrheic patients (0.5%) (p < 0.05).…”

Section: Discussionmentioning

confidence: 53%

Astrovirus infection in children living in the Central West region of Brazil

Santos¹,

Borges²,

Costa

et al. 2007

Mem. Inst. Oswaldo Cruz

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This study presents data regarding the circulation of astrovirus in Goiânia-GO and Brasília-DF. These viruses were detected in fecal samples from hospitalized children up to five years old with and without acute gastroenteritis. A total of 1244 fecal samples were collected in two periods, 1994 to 1996 (Brasília) and 1998, and were analyzed for viral RNA using the reverse transcription-polymerase chain reaction (RT-PCR)

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Section: Discussionmentioning

confidence: 53%

Astrovirus infection in children living in the Central West region of Brazil

Santos¹,

Borges²,

Costa

et al. 2007

Mem. Inst. Oswaldo Cruz

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“…These situations are relatively common in gastroenteritis episodes, as described by other 9,18,25,36,44 authors . This fact probably reflects the poor sanitation conditions and the low socioeconomic environment in which these children live.…”

Section: Frommentioning

confidence: 53%

Molecular characterization of norovirus, sapovirus and astrovirus in children with acute gastroenteritis from Belém, Pará, Brazil

et al. 2010

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Molecular characterization of norovirus, sapovirus and astrovirus in children with acute gastroenteritis from Belém, Pará, Brazil Caracterização molecular de norovírus, sapovírus e astrovírus em crianças com gastroenterite aguda em Belém, Pará, Brasil Caracterización molecular de norovirus, sapovirus y astrovirus en niños con gastroenteritis aguda en Belém (Pará, Brasil) http://revista.iec.pa.gov.br Glicélia Cruz Aragão ABSTRACTThe importance of norovirus (NoVs), sapovirus (SaVs) and human astrovirus (HAstVs) as causes of gastroenteritis outbreaks is already well-defined, but a few studies have described sporadic cases of acute gastroenteritis caused by these viral entities. The aim of this study was to determine the role of these viruses in the etiology of acute gastroenteritis in children enrolled to participate in hospital -and emergency department -based intensive surveillance carried out in Belém, Brazil, from March to September 2003. A total of 305 stool specimens from patients with severe gastroenteritis were collected and screened by reverse transcription followed by polymerase chain reaction (RT-PCR), using the specific primers Mon 269 and Mon 270 for HAstVs, p289 and p290 for human calicivirus (HuCVs), and Mon 431/433 and Mon 432/434 for NoVs. Sequencing of RT-PCR HAstV, HuCV and NoV amplicons was carried out using the same primers. Of the 305 samples tested, 96 (31.5%) were positive, with 51 diagnosed as HuCVs, 40 as HAstVs and five as mixed infections. Of the 56 (18.4%) HuCVs sequenced, 30 were NoVs (9.8%) of genogroups and 15 (4.9%) were SaVs of types GI-1, GI-2 and GII-1. HAstVs, including genotypes 1, 8 and 2, were detected in 45 (14.7%) samples. This study has highlighted the importance of these viruses as causes of acute gastroenteritis and established the circulation of different genotypes during the study period. These results reinforce the need for establishing an intensive surveillance for gastroenteritis caused by these viruses to assess the burden of disease and to monitor the circulation of genotypes.

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“…The main symptom of infection by astroviruses is a watery diarrhea that may be associated with fever, vomiting, anorexia and abdominal pain 32 . In Venezuela and Argentina, the virus was undetected 42 or detected at frequencies of 4% 39 in people with HIV, respectively, without, however, being significantly associated with diarrhea.…”

Section: Virusmentioning

confidence: 99%

Etiological agents of diarrhea in patients infected by the human immunodeficiency virus-1: a review

Rossit¹,

Gonçalves

Franco

et al. 2009

Rev. Inst. Med. trop. S. Paulo

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Despite the importance of understanding the epidemiology of agents responsible for infectious diarrhea in human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) population, the number of articles about this subject is relatively few. The current article summarizes published data on bacterial, fungal, viral and parasitic enteropathogens in the HIV/AIDS seropositive subjects in different countries, regions and localities. In general, there is a great difference in the frequencies of etiological agents due to factors which include immune status, geographical location, climate and socioeconomic conditions. It is important to stress that a great prevalence of infection by emergent agents has been reported in the more advanced stages of AIDS. Therefore, to establish specific treatment depends directly on knowledge of these agents and risk factors associated to their distribution. Moreover, the colonization by potential pathogenic agents verified in these individuals is high thus implicating that they act as carriers. Finally, public health measures of control and prevention must take into consideration the regional previously identified enteropathogens, especially in areas where HIV prevalence is high.

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Prevalence and genetic diversity of astroviruses in children with and without diarrhea in São Luís, Maranhão, Brazil

Abstract: Human astroviruses (HAstV)

Cited by 29 publications

References 30 publications

Astrovirus infection in children living in the Central West region of Brazil

Astrovirus infection in children living in the Central West region of Brazil

Molecular characterization of norovirus, sapovirus and astrovirus in children with acute gastroenteritis from Belém, Pará, Brazil

Etiological agents of diarrhea in patients infected by the human immunodeficiency virus-1: a review

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