Schistosomiasis and associated infections

Lambertucci, José Roberto; Rayes, Abdunnabi Ahmed Mustafa; Serufo, José Carlos; Gerspacher-Lara, Rogério; Brasileiro-Filho, Geraldo; Teixeira, Rosângela; Antunes, Carlos Maurício de Figueiredo; Góes, Alfredo M.; Coelho, Paulo Marcos Zech

doi:10.1590/s0074-02761998000700019

Cited by 35 publications

(18 citation statements)

References 34 publications

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“…Cytokines produced by activated Th2 cells further enhance Th2-type responses and inhibit the Th1 arm of the immune system, thereby contributing to granuloma formation, eosinophilia, hyperimmunoglobulin, and increased susceptibility to bacterial and fungal infections. 18,20,21 Thus, the proportion of patients with secondary bacterial infection was higher than in other regions of Taiwan.…”

Section: Discussionmentioning

confidence: 96%

Clinical Manifestations and Risk Factors of Amebic Liver Abscess in Southeast Taiwan Compared with Other Regions of Taiwan

Chen

Bair

Lin

et al. 2013

The American Journal of Tropical Medicine and Hygiene

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Abstract. Amebic liver abscess (ALA) had previously been endemic in Taiwan, particularly in the southern region, although its occurrence in the southeastern area was unknown. Thus, we conducted a retrospective study for southeastern Taiwan. We identified 14 patients who were diagnosed with ALA between July of 1995 and July of 2008. These patients were predominantly male and older in age. Most patients lived in rural areas (85.7%). Alcoholism (78.6%) and diabetes (35.7%) were risk factors for ALA. No human immunodeficiency virus (HIV) infections were detected. The most common clinical symptoms were fever (100%) and abdominal pain (100%). Short mean durations of symptoms, high bilirubin levels, and low albumin levels were also noted. Most patients (92.86%) had a single lesion, particularly in the right liver lobe (71.4%). Six patients also had secondary Klebsiella pneumoniae bacterial infections. Clinicians should be aware of the different risk factors in different regions when diagnosing amebic liver abscess in Taiwan.

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Section: Discussionmentioning

confidence: 96%

Clinical Manifestations and Risk Factors of Amebic Liver Abscess in Southeast Taiwan Compared with Other Regions of Taiwan

Chen

Bair

Lin

et al. 2013

The American Journal of Tropical Medicine and Hygiene

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“…In endemic areas, schistosomotics are frequently heavy drinkers. Is there really a place in the world for pure schistosomiasis 74,75,[76][77][78][79][80][81][82] ?…”

Section: Pure Schistosomiasismentioning

confidence: 99%

Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools

Lambertucci

2014

Rev. Soc. Bras. Med. Trop.

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Different aspects of hepatosplenic schistosomiasis are revisited here. Manson's schistosomiasis causes periportal fi brosis and portal hypertension in approximately 6% of infected subjects, usually with preservation of their hepatic function. The assessment of liver involvement is of major importance in determining the prognosis and risk of complications from schistosomiasis, such as upper digestive bleeding secondary to variceal rupture. For many years, the diagnosis of hepatosplenic schistosomiasis and liver fi brosis was made by abdominal palpation and the fi nding of liver and/or spleen enlargement. However, there is no consensus regarding the clinical parameters of the liver and spleen to be considered in this physical evaluation. For the last three decades, abdominal ultrasound (US) has become the best imaging technique to evaluate liver fi brosis caused by schistosomiasis mansoni. However, US is a subjective procedure and is therefore examiner-dependent. Magnetic resonance imaging (MRI) fi ndings have provided valuable information in addition to ultrasound and clinical examination. The combination of a comprehensive history and physical examination, basic laboratory tests (a stool examination for Schistosoma mansoni eggs and a blood cell count), biomarkers for liver fi brosis/portal hypertension and imaging methods seem to offer the best approach for evaluating patients with this disease. In situations where research is involved or in patients with severe disease, MRI may be considered.

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“…The association of schistosomiasis and hepatotropic virus infection is well known, possibly a result of blood transfusion to treat variceal bleeding; thus, it is not possible to exclude the role of concurrent hepatitis C-related cirrhosis in studies carried out before the 1990s. [12][13][14] The association of PH and schistosomiasis favors the concept that specific causes of PH may be of particular importance in developing countries. 15 The aim of the present study was to determine the prevalence of PH in hepatosplenic schistosomiasis.…”

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confidence: 99%

Cardiopulmonary Manifestations of Hepatosplenic Schistosomiasis

Lapa

Dias²,

Jardim³

et al. 2009

Circulation

178

150

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Background -Schistosomiasis is a highly prevalent disease with Ͼ200 million infected people. Pulmonary hypertension is one of the pulmonary manifestations in this disease, particularly in its hepatosplenic presentation. The aim of this study was to determine the prevalence of pulmonary hypertension in schistosomiasis patients with the hepatosplenic form of the disease. Methods and Results -All patients with hepatosplenic schistosomiasis followed up at the gastroenterology department of our university hospital underwent echocardiographic evaluation to search for pulmonary hypertension. Patients presenting with systolic pulmonary artery pressure Ͼ40 mm Hg were further evaluated through right heart catheterization. Our study showed an 18.5% prevalence of patients with elevated systolic pulmonary artery pressure at echocardiography. Invasive hemodynamics confirmed the presence of pulmonary hypertension in 7.7% (95% confidence interval, 3.3 to 16.7) of patients, with a prevalence of precapillary (arterial) pulmonary hypertension of 4.6% (95% confidence interval, 1.5 to 12.7). Conclusions -Our study reinforces the role of echocardiography as a screening tool in the investigation of pulmonary hypertension, together with the need for invasive monitoring for a proper diagnosis. We conclude that hepatosplenic schistosomiasis may account for one of the most prevalent forms of pulmonary hypertension worldwide, justifying the development of further studies to evaluate the effect of specific pulmonary hypertension treatment in this particular form of the disease.

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Schistosomiasis and associated infections

Cited by 35 publications

References 34 publications

Clinical Manifestations and Risk Factors of Amebic Liver Abscess in Southeast Taiwan Compared with Other Regions of Taiwan

Clinical Manifestations and Risk Factors of Amebic Liver Abscess in Southeast Taiwan Compared with Other Regions of Taiwan

Revisiting the concept of hepatosplenic schistosomiasis and its challenges using traditional and new tools

Cardiopulmonary Manifestations of Hepatosplenic Schistosomiasis

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