Cardiopulmonary Manifestations of Hepatosplenic Schistosomiasis

Lapa, Mônica Silveira; Dias, Bruno; Jardim, Carlos; Fernandes, Constantino José; Dourado, Paulo Magno Martins; Figueiredo, Margarida Garcia de; Farias, Alberto Queiróz; Tsutsui, Jeane Mike; Filho, Mário Terra; Humbert, Marc; Souza, Rogério

doi:10.1161/circulationaha.108.803221

Cited by 182 publications

(168 citation statements)

References 34 publications

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“…This study suggests that the etiology of pulmonary hypertension may be closely associated to portal hypertension, a physiopathogeny that shows no significant pulmonary vasoreactivity 8,3 , which is in disagreement with other studies that indicate many similarities between these etiologies, with SPAH being recently reclassified from group IV to group I 17,[27][28][29] . The findings in the analysis are consistent with the fact that patients with SPAH are vasoreactive, but at a value below those recorded for idiopathic PAH, which is around 20% 30 .…”

Section: Discussioncontrasting

confidence: 89%

Perfil hemodinâmico de gravidade ao teste de vasorreatividade pulmonar em esquistossomóticos

Japyassú¹,

Mendes²,

Bandeira³

et al. 2012

Arq. Bras. Cardiol.

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Section: Discussioncontrasting

confidence: 89%

Perfil hemodinâmico de gravidade ao teste de vasorreatividade pulmonar em esquistossomóticos

Japyassú¹,

Mendes²,

Bandeira³

et al. 2012

Arq. Bras. Cardiol.

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“…In certain at-risk groups, however, the occurrence of PAH is substantially higher. For example, the prevalence is 0.5% in HIV-infected patients [10] and 4-6% in schistosomiasis [11]. These diseases are far more common in developing countries with limited health care and, thus, the real burden of PAH worldwide is probably underestimated.…”

mentioning

confidence: 99%

Registries for paediatric pulmonary hypertension

Hansmann

Hoeper

2013

Eur Respir J

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@ERSpublications Paediatric pulmonary arterial hypertension should be treated specifically and differently from adult pulmonary arterial hypertension http://ow.ly/mzPDT Pulmonary arterial hypertension (PAH) is a progressive, angio-obliterative disease leading to increased pulmonary vascular resistance, right heart failure, and death in ,25-60% of PAH patients 5 years after diagnosis [1][2][3]. The estimated prevalence of PAH is 15-50 cases per million adults [4-6] and 2-16 cases per million children [7][8][9]. In certain at-risk groups, however, the occurrence of PAH is substantially higher. For example, the prevalence is 0.5% in HIV-infected patients [10] and 4-6% in schistosomiasis [11]. These diseases are far more common in developing countries with limited health care and, thus, the real burden of PAH worldwide is probably underestimated.Historically, extrapolation from adult pulmonary hypertension studies has been used to make assumptions on the disease in children; however, this approach is neither validated nor appropriate [12]. The recent comprehensive analysis of paediatric registries allowed predictions on the epidemiology, clinical practice and outcome of PAH in childhood. In France, for example, the prevalence of paediatric PAH was estimated to be 2.2 cases per million children [7]. In the UK, the incidence and prevalence of idiopathic PAH (IPAH) was 0.48 and 2.1 per million children, respectively [8]. In the Netherlands, the incidence and prevalence of IPAH was 0.7 and 4.4 per million children, whereas PAH associated with congenital heart disease (PAH-CHD) had an incidence of 2.2 and prevalence of 15.6 per million [9]. Of note, the PAH disease spectrum may somewhat differ in the individual tertiary centre and in multicentre registries [13]. In a British cohort study, the 5-year survival for children with IPAH was only 75% with a freedom from death or transplantation of only 57% (1986 and 2000 with follow-up to 2007) [8].Patients, family members and healthcare providers should be aware of the unique features of paediatric pulmonary hypertensive vascular disease (PPHVD) [14,15]. These include the fetal origins, developmental and adaptive aspects of pulmonary vascular disease (PVD) and right ventricular dysfunction (RVD) in both childhood-and adult-onset disease. The proposal for a new classification of PPHVD (Panama, 2011 [14]) aims to incorporate such specific paediatric aspects that are not adequately addressed in the current classification of pulmonary hypertension (Dana Point, CA, USA, 2008) [16]. The Panama proposal of PPHVD is still very new, not broadly (internationally) accepted yet, and probably will undergo further modifications, according to international meetings (e.g., the PH World Symposium, Nice, France, 2013) and feedback from healthcare providers.

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“…Multiple contrasts enhanced thoracic scans and pulmonary ventilation-perfusion scintigraphy did not denote the presence of a chronic or acute thromboembolic process. A schistosomiasis infection had also been excluded to rule out a possible Katayama syndrome [20] of PAH [21][22][23]. No parenchymal abnormalities have been seen on all the thoracic scans and a nocturnal saturometry did not correlate with the presence of sleep apnea.…”

Section: Discussionmentioning

confidence: 99%

STILL out of Breath?

Robillard

2013

J Med Cases

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Adult onset Still's disease (AOSD) is a rare inflammatory syndrome mostly seen in young adults. Known for its wide range of clinical manifestations, AOSD often presents with non-remitting systemic signs and symptoms. Many rare case associations have been described with AOSD, but only few with pulmonary hypertension (PAH). We are presenting a sixth known case of a young female adult with AOSD and PAH in the literature.

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Cardiopulmonary Manifestations of Hepatosplenic Schistosomiasis

Cited by 182 publications

References 34 publications

Perfil hemodinâmico de gravidade ao teste de vasorreatividade pulmonar em esquistossomóticos

Perfil hemodinâmico de gravidade ao teste de vasorreatividade pulmonar em esquistossomóticos

Registries for paediatric pulmonary hypertension

STILL out of Breath?

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