Adenosine Deaminase Activities in Sera, Lymphocytes and Granulocytes in Patients with Cutaneous Leishmaniasis

Erel, Özcan; Koçyiğit, Abdürrahim; Gürel, Mehmet Salih; Bulut, Vedat; Seyrek, Adnan; Özdemir, Yüksel

doi:10.1590/s0074-02761998000400014

Cited by 37 publications

(25 citation statements)

References 24 publications

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“…At diagnosis, activity appeared higher in VL patients than in malaria, leprosy, or tuberculosis patients (60). Also, in Turkish CL patients, adenosine deaminase was increased at the time of diagnosis (63).…”

Section: Identified Biomarkersmentioning

confidence: 92%

Systematic Review of Biomarkers To Monitor Therapeutic Response in Leishmaniasis

Kip

Balasegaram

Beijnen

et al. 2015

Antimicrob Agents Chemother

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e Recently, there has been a renewed interest in the development of new drugs for the treatment of leishmaniasis. This has spurred the need for pharmacodynamic markers to monitor and compare therapies specifically for visceral leishmaniasis, in which the primary recrudescence of parasites is a particularly long-term event that remains difficult to predict. We performed a systematic review of studies evaluating biomarkers in human patients with visceral, cutaneous, and post-kala-azar dermal leishmaniasis, which yielded a total of 170 studies in which 53 potential pharmacodynamic biomarkers were identified. In conclusion, the large majority of these biomarkers constituted universal indirect markers of activation and subsequent waning of cellular immunity and therefore lacked specificity. Macrophage-related markers demonstrate favorable sensitivity and times to normalcy, but more evidence is required to establish a link between these markers and clinical outcome. Most promising are the markers directly related to the parasite burden, but future effort should be focused on optimization of molecular or antigenic targets to increase the sensitivity of these markers. In general, future research should focus on the longitudinal evaluation of the pharmacodynamic biomarkers during treatment, with an emphasis on the correlation of studied biomarkers and clinical parameters.

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Section: Identified Biomarkersmentioning

confidence: 92%

Systematic Review of Biomarkers To Monitor Therapeutic Response in Leishmaniasis

Kip

Balasegaram

Beijnen

et al. 2015

Antimicrob Agents Chemother

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“…ADA is found in most cells, but its chief role concerns the proliferation and differentiation of lymphocytes especially T lymphocytes (Ozcan et al, 1998).…”

Section: Discussionmentioning

confidence: 99%

Serum Adenosine Deaminase Level in Iraqi Women with Toxoplasmosis with a History of Abortion

Al-khafaji¹,

Aljeboori²,

Juma³

2016

American Journal of Microbiology

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Sixty women who had abortion were selected for this study. Serum was collected from the women. ELISA test was used to detect antiToxoplasma specific antibodies. Those women were divided into three groups according to the presence or absence of specific anti-Toxoplasma antibodies. These groups included the women with IgG (18), the women with IgM (14) and the women with both IgG and IgM (12). The other 16 women had no antibodies against Toxoplasma. Twenty-four healthylooking women had been selected as controls. Serum was collected from those women and tested for anti-Toxoplasma antibodies. Those that revealed any antibody titer against Toxoplasma were excluded from the study. The activity of ADA was determined in the serum according to the method of Giusti. The mean concentration of ADA in the women who had anti-Toxoplasma IgM antibody was significantly higher (P<0.0001) than that of healthy controls and the women who had IgG, while there was no significant differences between women who had IgG antibody and healthy controls (P>0.05). Since a relationship exists between ADA activity and the cell mediated immune response, this result confirms the fact that Toxoplasma antigen induces T-lymphocytes proliferation.

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“…Increased serum ADA activities have been observed in many infectious diseases caused by microorganisms infecting mainly the macrophages, in tuberculosis, leprosy, visceral and cutaneous leishmaniasis, brucellosis and, in human deficiency virus (HIV) infection (Gakis et al 1989, Valls et al 1990, Erel et al 1998. It was reported that 95% of serologically positive typhoid fever cases found to have increased ADA activity (Ungerer et al 1996).…”

Section: Discussionmentioning

confidence: 99%

Adenosine Deaminase and Guanosine Deaminase Activities in Sera of Patients with Viral Hepatitis

Kalkan

Bulut

Erel

et al. 1999

Mem. Inst. Oswaldo Cruz

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Adenosine Deaminase Activities in Sera, Lymphocytes and Granulocytes in Patients with Cutaneous Leishmaniasis

Abstract: Adenosine deaminase (ADA)

Cited by 37 publications

References 24 publications

Systematic Review of Biomarkers To Monitor Therapeutic Response in Leishmaniasis

Systematic Review of Biomarkers To Monitor Therapeutic Response in Leishmaniasis

Serum Adenosine Deaminase Level in Iraqi Women with Toxoplasmosis with a History of Abortion

Adenosine Deaminase and Guanosine Deaminase Activities in Sera of Patients with Viral Hepatitis

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