Human cutaneous leishmaniasis due to a new enzymatic variant of Leishmania (Viannia) braziliensis occurring in Pernambuco, Brazil

Brito, Maria Edileuza Felinto de; Brandão, S. P.; Salles, N. R.; Cupolillo, Elisa; Júnior, Gabriel Grimaldi; Momen, Hooman

doi:10.1590/s0074-02761993000400024

Cited by 16 publications

(8 citation statements)

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“…( V .) braziliensis is polymorphic [5, 10, 35, 36, 53]. The lack of polymorphism in our study is perhaps due to the fact that only three species of phlebotomine sand flies have been incriminated as the vectors of L .…”

Section: Discussionmentioning

confidence: 73%

Phenotypic characterization ofLeishmaniaspp. causing cutaneous leishmaniasis in the lower Amazon region, western Pará state, Brazil, reveals a putative hybrid parasite,Leishmania(Viannia)guyanensis × Leishmania(Viannia)shawi shawi

et al. 2014

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We phenotypically characterized 43 leishmanial parasites from cutaneous leishmaniasis by isoenzyme electrophoresis and the indirect immunofluorescence antibody test (23 McAbs). Identifications revealed 11 (25.6%) strains of Leishmania (V.) braziliensis, 4 (9.3%) of L. (V.) shawi shawi, 7 (16.3%) of L. (V.) shawi santarensis, 6 (13.9%) of L. (V.) guyanensis and L. (V.) lainsoni, 2 (4.7%) of L. (L.) amazonensis, and 7 (16.3%) of a putative hybrid parasite, L. (V.) guyanensis/L. (V.) shawi shawi. McAbs detected three different serodemes of L. (V.) braziliensis: I-7, II-1, and III-3 strains. Among the strains of L. (V.) shawi we identified two populations: one (7 strains) expressing the B19 epitope that was previously considered to be species-specific for L. (V.) guyanensis. We have given this population sub-specific rank, naming it L. (V.) s. santarensis. The other one (4 strains) did not express the B19 epitope like the L. (V.) shawi reference strain, which we now designate as L. (V.) s. shawi. For the first time in the eastern Brazilian Amazon we register a putative hybrid parasite (7 strains), L. (V.) guyanensis/L. (V.) s. shawi, characterized by a new 6PGDH three-band profile at the level of L. (V.) guyanensis. Its PGM profile, however, was very similar to that of L. (V.) s. shawi. These results suggest that the lower Amazon region – western Pará state, Brazil, represents a biome where L. (V.) guyanensis and L. (V.) s. shawi exchange genetic information.

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Section: Discussionmentioning

confidence: 73%

Phenotypic characterization ofLeishmaniaspp. causing cutaneous leishmaniasis in the lower Amazon region, western Pará state, Brazil, reveals a putative hybrid parasite,Leishmania(Viannia)guyanensis × Leishmania(Viannia)shawi shawi

et al. 2014

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“…The heterogeneity observed in mixed infections involving L. ( V. ) guyanensis , L. ( V. ) braziliensis , L. ( V. ) naiffii , and L. ( L. ) amazonensis and their capacity for concomitant survival while causing ATL, contrasts with the homogeneity of parasites isolated in other regions, particularly in the northeast and southeast of Brazil (Brito et al 1993; Brandão-Filho et al 2003; Cupolillo et al 2003). Brito et al (2009) verified 10 different zymodemes in isolates of L. ( V. ) braziliensis and Leishmania ( Viannia ) shawii , originating from the Atlantic Forest zone in Pernambuco, northeastern Brazil, confirming the coexistence of two species that divided the same ecosystem and interfered in the natural genetic polymorphism of the Leishmania spp.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Leishmania spp. causing cutaneous leishmaniasis in Manaus, Amazonas, Brazil

et al. 2010

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In the State of Amazonas, American tegumentary leishmaniasis is endemic and presents a wide spectrum of clinical variability due to the large diversity of circulating species in the region. Isolates from patients in Manaus and its metropolitan region were characterized using monoclonal antibodies and isoenzymes belonging to four species of the parasite: Leishmania (Viannia) guyanensis, 73% (153/209); Leishmania (Viannia) braziliensis, 14% (30/209); Leishmania (Leishmania) amazonensis, 8% (17/209); and Leishmania (Viannia) naiffii, 4% (9/209). The most prevalent species was L. (V.) guyanensis. The principal finding of this study was the important quantity of infections involving more than one parasite species, representing 14% (29/209) of the total. The findings obtained in this work regarding the parasite are further highlighted by the fact that these isolates were obtained from clinical samples collected from single lesions.

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“…The cases occur predominantly in the "Zona da Mata", with more than 60.0% of the total reports 8 . Samples of Leishmania (Viannia) braziliensis were isolated from human patients and small wild and synanthropic mammals in a longitudinal study in the municipality (county) of Amaraji, in the southern Zona da Mata of the State, and L. whitmani is the predominant vector species 9,10,11 .…”

Section: Leishmaniasis; Insect Vectors; Psychodidaementioning

confidence: 99%

Sandfly fauna in a military training area endemic for American tegumentary leishmaniasis in the Atlantic Rain Forest region of Pernambuco, Brazil

Andrade¹,

Valença

Silva

et al. 2005

Cad. Saúde Pública

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The aim of this study was to characterize the sandfly fauna in a military training area situated in the "Zona da Mata" region of Pernambuco State, Brazil, where human cases of American tegumentary leishmaniasis (ATL) had been observed, caused by Leishmania (Viannia) braziliensis. The occurrence of 16 sandfly species in the Marshall Newton Cavalcanti Military Training Camp (CIMNC) indicates an important diversity of sandfly species in this study area. Lutzomyia complexa was the most common species (51.36%) followed by L. choti (43.54%). All the captures were made in areas where training activities were conducted and where clinical cases had been detected in individuals performing training, following this period. The data relating the sandfly behavior to previous data in the same area provides strong evidence for the occurrence of an enzootic cycle of the parasite, and outbreaks followed the period of training activities in the remaining Atlantic Rain Forest and secondary forest areas.

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Human cutaneous leishmaniasis due to a new enzymatic variant of Leishmania (Viannia) braziliensis occurring in Pernambuco, Brazil

Cited by 16 publications

References 0 publications

Phenotypic characterization ofLeishmaniaspp. causing cutaneous leishmaniasis in the lower Amazon region, western Pará state, Brazil, reveals a putative hybrid parasite,Leishmania(Viannia)guyanensis × Leishmania(Viannia)shawi shawi

Phenotypic characterization ofLeishmaniaspp. causing cutaneous leishmaniasis in the lower Amazon region, western Pará state, Brazil, reveals a putative hybrid parasite,Leishmania(Viannia)guyanensis × Leishmania(Viannia)shawi shawi

Characterization of Leishmania spp. causing cutaneous leishmaniasis in Manaus, Amazonas, Brazil

Sandfly fauna in a military training area endemic for American tegumentary leishmaniasis in the Atlantic Rain Forest region of Pernambuco, Brazil

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