Functional and antigenic properties of the major cysteine proteinase (GP57/51) of Trypanosoma cruzi

Meirelles, Maria de Nazareth Leal de; Juliano, Luiz; Carmona, Eurı́dice; Costa, Elaine; Silva, S. G.; Arnholdt, Andrea Cristina Vetö; Leme, V. M. C.; Guimarães, E. S. P.; Berro, O. J.; Scharfstein, Júlio

doi:10.1590/s0074-02761990000400027

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The Reservosome1

Synthese Und Antiprotozoen-aktivität Von 35-disubstituierte1

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Cited by 11 publications

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“…One characteristic feature of the reservosome in T. cruzi is to accumulate a large amount of cruzipain, the major cysteine proteinase found in the cell , Meirelles et al 1990, Murta et al 1990). Although glicosylated, these proteins do not present mannose-6-phosphate residues.…”

Section: The Reservosomementioning

confidence: 99%

Two special organelles found in Trypanosoma cruzi

Souza

Porto

Miranda

et al. 2000

An. Acad. Bras. Ciênc.

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We review here two unique organelles from Trypanosoma cruzi. One of them is the acidocalcisome, cytoplasmic vacuoles containing a very high Ca 2+ concentration and a Ca 2+ − H + translocating ATPase activity, present in all trypanosomatids. The other organelle is the reservosome, site of accumulation of endocytosed macromolecules, very rich in cysteine proteinase, that is present only in epimastigote forms of trypanosomes belonging to the Schyzotrypanum sub-genus.

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Section: The Reservosomementioning

confidence: 99%

Two special organelles found in Trypanosoma cruzi

Souza

Porto

Miranda

et al. 2000

An. Acad. Bras. Ciênc.

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show abstract

“…Cysteine proteinases have been detected in most groups of parasitic protozoa [7]. A new approach in the search of antiprotozoan drugs is the design of prodrugs that would inactivate the parasite cysteine proteinase [7,8]. On the other hand, the interaction of isothiocyanates and cysteine has been demonstrated [3].…”

Section: Synthese Und Antiprotozoen-aktivität Von 35-disubstituiertementioning

confidence: 99%