Insulina imunoreativa em líquidos biológicos

Abstract

No presente trabalho, estudamos a insulina imunoreativa no sangue, urina e sêmen de 138 indivíduos. No sangue, verficamos a secração de insulina em indivíduos normais e com diferentes afecções endócrinas. Na urina, estudamos a clearance de insulina em normais, assim como a possibilidade da existência de correlação entre insulinúria e proteinúria. Finalmente, estabelecemos os valores de insulina no sêmen de amostras humanas normospérmicas e azoospérmicas.<br>Insulin secretion coeffiecient is quite a valuable test for studying beta cell function. It was increased in obesity and acromegalics and diminished in maturity-onset diabetes and hyperlipoproteinemia type IV. We were unable in this work to establish any correlation between insulinemia and insulinuria. No relation was also observed between clearances of insulin and creatinine. Immunoreactive insulin is also present in human seminal fluid in a concentration of approximately 45,0 uU/ml

Obesity is associated with increased seminal insulin and leptin alongside reduced fertility parameters in a controlled male cohort

“…Based on the seminal-to-serum insulin ratio, insulin was found to be highly concentrated in human semen in both groups. The concentration of insulin in human semen is somewhat supported by a limited number of studies across numerous groups, including fertile and infertile normoglycaemic subjects, carbohydrate intolerant subjects and excretory and secretary azoospermic subjects [ 42 , 45 , 46 ]. No plausible explanation for a physiological concentration of insulin in semen is apparent on a search of the literature.…”