Obesity is associated with increased seminal insulin and leptin alongside reduced fertility parameters in a controlled male cohort

Leisegang, Kristian; Bouic, Patrick; Menkveld, Roelof; Henkel, Ralf

doi:10.1186/1477-7827-12-34

Cited by 99 publications

(90 citation statements)

References 44 publications

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“…While a statistically significant negative relationship was detected between BMI and semen volume, concentration and motility in a comprehensive cohort study including 10665 patients conducted by Belloc et al, no relationship with morphology was detected (18). In another study with 42 patients conducted by Leisegang et al, it was reported that BMI level and sperm concentration are negatively correlated and no correlation was detected with motility and morphology (19). In a cohort study, which Stewart et al conducted with 225 fertile male patients, it was reported that BMI and sperm count are negatively correlated (20).…”

Section: Discussionmentioning

confidence: 90%

Investigation of the effect of body mass index (BMI) on semen parameters and male reproductive system hormones

Keskın

Budak

Aksoy

et al. 2017

Arch Ital Urol Androl

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Aim: To evaluate the effects of body mass index (BMI) ratio on semen parameters and serum reproductive hormones. Materials and methods: The data of 454 patients who prsented to male infertility clinics in our hospital between 2014 and 2015 were analyzed retrospectively. Weight, height, serum hormone levels and semen analysis results of the patients were obtained. BMI values were calculated by using the weight and height values of the patients and they were classified as group 1 for BMI values ≤ 25 kg/m 2 , as group 2 for BMI values 25-30 kg/m 2 and as group 3 for BMI values ≥ 30 kg/m 2 . Results: The mean values of BMI, semen volume, concentration, total motility, progressive motility, total progressive motile sperm count (TPMSC), normal morphology according to Kruger, head abnormality, neck abnormality, tail abnormality, FSH, LH, prolactin, T/E2, total testosterone and estradiol parameters of the patients were considered. Patients were divided according to BMI values in Group 1 (n = 165), Group 2 (n = 222) and Group 3 (n = 56). There was no statistically significant difference in terms of all variables between the groups. Conclusions: We analyzed the relationship between BMI level and semen parameters and reproductive hormones, demonstrating no relationship between BMI and semen parameters. In our study, BMI does not affect semen parameters although it shows negative correlation with prolactin and testosterone levels.KEY WORDS: Infertility; BMI; Semen parameters; Reproductive hormones. number of studies and in some studies this decrease was found as associated to the increase in obesity prevalence (2). But, there is not a consensus in the literature and contradictory results were published. In this study, we analyzed the effect of BMI on semen parameters and the relationship with reproductive hormone levels. MATERIALS AND METHODSThe data of 454 patients who presented to male infertility clinics in our hospital between 2014 and 2015 were analyzed retrospectively. Weight, height, serum hormone levels and semen analysis results of the patients were considered. BMI values were calculated by using the weight and height values of the patients and they were classified as Group 1 for BMI values ≤ 25 kg/m 2 , as Group 2 for BMI values 25-30 kg/m 2 and as Group 3 for BMI values ≥ 30 kg/m 2 . Semen analysis was performed after a 3-5 days of sexual abstinence. Semen analysis was performed according to WHO 2010 criteria (semen volume ≥ 1.5 ml; sperm concentration ≥ 15 × 106/ml; total motility ≥ 40%, progressive motility ≥ 32% and morphology ≥ 4%). After 5-30 minutes of sample collection, the analysis was performed after the sample was liquefied. For the microscopic examination in semen analysis, phase contrast light microscope was used and the examination was performed with 10 x 20 magnification. For sperm concentration, Makler counting chamber was used and the sperm count (concentration) was found in million/ml with the sperm count in 10 squares in a 100 square area. Motility was evaluated in 3 Groups as linear progressive...

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Section: Discussionmentioning

confidence: 90%

Investigation of the effect of body mass index (BMI) on semen parameters and male reproductive system hormones

Keskın

Budak

Aksoy

et al. 2017

Arch Ital Urol Androl

View full text Add to dashboard Cite

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“…A small study with 42 men further reported that obese men had decreased sperm concentration and vitality, as well as increased sperm DNA fragmentation. Additionally, seminal and serum leptin concentrations were correlated in those individuals, suggesting that leptin may have a deleterious effect on male reproductive function through an direct action on HPT axis or on specific sites (Leisegang et al 2014). Indeed, the presence of Ob-R in testis, and particularly in testicular cells such as Leydig and Sertoli cells, also suggests that leptin may have a direct action on testicular cells (Fig.…”

Section: Energy Balance Hormonal Dysfunction and Male Reproductionmentioning

confidence: 92%

Obesity, energy balance and spermatogenesis

Oliveira¹,

Sousa²,

Silva³

et al. 2017

Reproduction

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Obesity has grown to pandemic proportions. It affects an increasing number of children, adolescents and young adults exposed to the silent comorbidities of this disorder for a longer period. Infertility has arisen as one important comorbidity associated with the energy dysfunction promoted by obesity. Spermatogenesis is a highly regulated process that is determined by specific energetic requirements. The reproductive potential of males relies on hormonal-dependent and -independent stimuli that control sperm quality. There are conflicting data concerning the impact of male overweight and obesity on sperm quality, as well as on the possible paternal-induced epigenetic trait inheritance of obesity. In addition, it remains a matter of debate whether massive weight loss induced by lifestyle interventions, drugs or bariatric surgery may or may not benefit obese men seeking fatherhood. Herein, we propose to discuss how energy balance may modulate hormonal signalling and sperm quality in overweight and obese men. We also discuss some molecular mechanisms that mediate obesity-related dysfunction in male reproductive system and how paternal obesity may lead to trait inheritance. Finally, we will discuss how lifestyle modifications and sustained weight loss, particularly the loss achieved by bariatric surgery, may revert some of the deleterious effects of obesity in men and their offspring.Reproduction (2017) 153 R173-R185

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“…Male obesity and (MS) are associated with hypogonadism [27]. Insulin and leptin, which are important regulators of male reproduction via modulation of the hypothalamus-pituitary-testes (HPT) axis, were detected in the seminal fluid of obese infertile men [28]. One such adipose-derived hormone is leptin, which is best known as a regulator of food intake and energy expenditure via hypothalamic-mediated effects.…”

Section: Discussionmentioning

confidence: 99%

Effect of Body Mass Index on Sperm Parameters and Sex Hormone Level in Sample of Infertile Iraqi Men

2017

ijs

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The objective of the present study was to investigate the effect of body mass index (BMI) on semen parameters, level of sex hormone and sperm DNA integrity. Semen samples were collected from (85) infertile men and (40) healthy fertile men with range of age (38.191 ± 0.84) years during their attendance at High Institute of Infertility Diagnosis and ART, Al-Nahrain University from March to June 2016. Semen samples were obtained by masturbation after 72 hours of abstinence. Seminal fluid analyses included semen volume, sperm concentration, percent sperm motility, percent sperm morphology, and sperm chromatin integrity DNA fragmentation index (DFI]). Serum samples were collected from each subject for determination the level of Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH), Prolactin (PRL), and Testosterone by ELISA method. The results revealed a highly significant (P≤ 0.01) increase in BMI and immotile sperm (%), and significant(P≤ 0.05) increase in semen liquefaction time, nonprogressive motility (%), round cells counts and sperm DNA fragmentation in infertile men as compared to control group, while there was a highly significant (P≤ 0.01) decrease in progressive motility (%), and a significant (P< 0.05) decrease in the sperm concentration, sperm motility (%) and normal sperm morphology (%). The results showed statistically significant (P< 0.05) positive correlations between body mass index and sperm motility, progressive motility, non-progressive motility, immotile sperm, normal sperm morphology and sperm DNA fragmentation. No significant correlations were observed between body mass index and semen liquefaction time, semen PH, sperm concentration, round cells counts and age. In respect with level of serum hormones a significant (P< 0.05) decrease in level of FSH ,LH and testosterone was found ,while the level of prolactin showed a significant (P< 0.05) increase in infertile men when compared with control group. Significant (P< 0.05) negative correlation was observed between body mass index and serum level of prolactin and testosterone, while nonsignificant correlations were observed between body mass index and serum level of FSH and LH. In conclusion, this study has shown that body mass index has major effect on semen characteristics and sex hormones. Science, 2017, Vol. 58, No.3B, pp: 1428-1236 ‫الجنسية.‬ ‫اليورمونات‬ ‫و‬ ‫النطف‬ ‫معايير‬ ‫عمى‬ ‫كبير‬ IntroductionObesity is a medical condition in which excess body fat, or white adipose tissue, accumulates in the body to the extent that the excess fat adversely affects health, the fundamental cause of obesity and overweight is an energy imbalance, where the energy consumed exceeds the energy expended. Global increases in overweight and obesity are attributable to a number of factors, including a shift in diet toward increased intake of energy-dense foods that are high in fat and sugars, and a trend toward decreased physical activity [1]. Body mass index (BMI) defined as the weight in kilograms divided by the square of the height in meters...

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Obesity is associated with increased seminal insulin and leptin alongside reduced fertility parameters in a controlled male cohort

Cited by 99 publications

References 44 publications

Investigation of the effect of body mass index (BMI) on semen parameters and male reproductive system hormones

Investigation of the effect of body mass index (BMI) on semen parameters and male reproductive system hormones

Obesity, energy balance and spermatogenesis

Effect of Body Mass Index on Sperm Parameters and Sex Hormone Level in Sample of Infertile Iraqi Men

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