Histoplasmose

“…Duarte 6 , em 1945, sob a forma de meningite, vários autores2,5,7,14,16,i8,i9,2i descreveram casos semelhantes, demonstrando a predominância da forma meningítica da doença sobre a forma de granulomas intraparenquimatosos. Shapiro e col. 18 revisaram seis casos de histoplasmose do sistema nervoso central e a compararam com a tuberculose, dividindo-a em três tipos: granulomas miliares com envolvimento de pequenas veias; granulomas localizados (histoplasmomas) e a forma meningítica.…”

Section: Desde O Primeiro Caso De Comprometimento Encefálico Descrito...unclassified

Histoplasmomas encefálicos múltiplos: estudo autópsico de um caso

Coutinho

Gelpi

Anicet

et al. 1981

Arq. Neuro-Psiquiatr.

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Report of the case of a 28-years-old black woman who developed changes in behavior followed by neurological alterations. The CT scans of the brain revealed multiple calcified granulomas. The patient died and the autopsy showed granulomatous lesions with central caseation in the brain. Microscopical examination disclosed numerous Histoplasma capsulatum. This is the first case of histoplasmoma of the brain described in Brazil.

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“…The disease is highly endemic in São Paulo, Rio de Janeiro, Minas Gerais, and Espírito Santo, including both primary and opportunistic histoplasmosis [5]. Rio de Janeiro state (RJ) has historical importance in histoplasmosis public health studies since the first chronic and disseminated cases of this disease in Brazil were reported here [8,9]. RJ is a highly endemic area with a 93.2% prevalence of skin histoplasmin sensitivity [10].…”

Section: Introductionmentioning

confidence: 99%

Genomic Diversity Analysis Reveals a Strong Population Structure in Histoplasma capsulatum LAmA (Histoplasma suramericanum)

Almeida-Silva

Teixeira

Matute

et al. 2021

JoF

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Histoplasmosis is a severe mycotic disease affecting thousands of immunocompetent and immunocompromised individuals with high incidence in Latin America, where the disease agents are Histoplasma capsulatum and Histoplasma suramericanum. In this work, we used whole-genome sequencing to infer the species diversity and the population structure of H. suramericanum in South America. We find evidence for strong population structure and little admixture within the species. Genome-level phylogenetic trees indicate the existence of at least three different discrete populations. We recovered the existence of a previously identified population, LAmB, and confirm that it is highly differentiated along the whole genome. We also find that H. suramericanum is composed of two populations, one in Northern South America, and another in the southern portion of the continent. Moreover, one of the lineages from the southern population is endemic to Rio de Janeiro and there was no association with clinical data and species isolated from patients with histoplasmosis. Our results point out the need to characterize the symptomatology of histoplasmosis caused by different species and lineages of Histoplasma spp.

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Histoplasmose

Cited by 8 publications

References 0 publications

Histoplasmosis in Cyprus: Report of Two Cases

Histoplasmosis in Cyprus: Report of Two Cases

Histoplasmomas encefálicos múltiplos: estudo autópsico de um caso

Genomic Diversity Analysis Reveals a Strong Population Structure in Histoplasma capsulatum LAmA (Histoplasma suramericanum)

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