Pesquisa da atividade antibacteriana com 180 amostras de Aspergillus Micheli, 1729

Furtado, Adolpho da Rocha

doi:10.1590/s0074-02761944000500001

Cited by 4 publications

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“…All of the fourteen groups into which the genus has been classified (Thorn & Raper, 1945) include one or more antibiotic-producing species (Brian, 1951). In the large Aspergillus glaucus group, nine species have previously been shown to produce antibacterial substances (Wilkins & Harris, 1942Gill-Carey, 1949 ;Furtado, 1944;Gupta & Viswanathan, 1955) and A. amstelodami can be added as a further example. Gill-Carey (1949) examined a strain of A. amstelodami and did not observe antibiotic activity, but this may illustrate the general principle that antibioticproduction is a strain, rather than a species, characteristic (Wilkins & Harris, 1945).…”

Section: Discussionmentioning

confidence: 99%

Antibiotics from Aspergillus amstelodami

Darling

Campbell

McArdle

1963

Journal of General Microbiology

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SUMMARYA strain of Aspergillus amstelodami, which antagonized the growth of Mycobacterium tuberculosis, was shown to produce at least two antibiotic substances. A liquid medium was developed for their production, and cultural and assay procedures were defined. The antibiotics appear to be distinct from previously described derivatives of the true fungi and were named Amodin A and Amodin B. Both are active against certain Grampositive and acid-fast organisms, but Amodin B has the wider antibiotic spectrum and is active against some Gram-negative organisms and strains of Candida albicans. Amodin A was produced in surface and submerged cultures, but in better yield in the latter; it was extracted and prepared as a crude product. It appears to be a moderately heat-labile peptide; though non-toxic to mice it did not prolong their survival when infected with Staphylococcus aureus or M . tuberculosis a t the dosage of antibiotic used. Amodin B appeared only in surface cultures and was mainly present in the mycelium, from which it was liberated by dilute acid. It is relatively heatstable and not inactivated by proteolytic enzymes. Amodin A production appears to be linked with the conidial mode of sporulation and Amodin B with the perithecial mode.

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Section: Discussionmentioning

confidence: 99%

Antibiotics from Aspergillus amstelodami

Darling

Campbell

McArdle

1963

Journal of General Microbiology

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“…1944 a, 1944 b, 1944 c; Furtado, 1944;Wiedling, 1944;Robbins, Hervey, Davidson, Ma & Robbins, 1945;Wilkins, 1946; and others) to produce diffusible substances inhibiting Staph. aureus, Bact.…”

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confidence: 99%

The Routine Examination for Antibiotics Produced by Moulds

Heatley

Philpot

1947

Journal of General Microbiology

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SUMMARY:From the existing methods for identifying common antibiotics it is possible to select tests for recognizing one or more of fourteen known antibiotics in crude culture medium. These tests, given in tabular form, are : (1) stability at pH 2.0 and 9.5; (2) ether-water partition at pH 2-0, 6.0-7.0 and 9.0; and (3) relative activity towards specified strains of Staphylococcus aureus and Bacterium coli. Further tests depend on destruction of penicillin by penicillinase, colour reactions, and volatility of aspergillic acid in steam. For final confirmation, isolation of the antibiotic may be necessary. Several hundreds of moulds have been reported (Wilkins

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Antibiotics produced by fungi

Pw¹

1951

Bot. Rev

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Pesquisa da atividade antibacteriana com 180 amostras de Aspergillus Micheli, 1729

Cited by 4 publications

References 0 publications

Antibiotics from Aspergillus amstelodami

Antibiotics from Aspergillus amstelodami

The Routine Examination for Antibiotics Produced by Moulds

Antibiotics produced by fungi

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