Antibiotics produced by fungi

Pw, Brian

doi:10.1007/bf02879038

Cited by 90 publications

(29 citation statements)

References 181 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…All of the fourteen groups into which the genus has been classified (Thorn & Raper, 1945) include one or more antibiotic-producing species (Brian, 1951). In the large Aspergillus glaucus group, nine species have previously been shown to produce antibacterial substances (Wilkins & Harris, 1942Gill-Carey, 1949 ;Furtado, 1944;Gupta & Viswanathan, 1955) and A. amstelodami can be added as a further example.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Antibiotics from Aspergillus amstelodami

Darling

Campbell

McArdle

1963

Journal of General Microbiology

View full text Add to dashboard Cite

SUMMARYA strain of Aspergillus amstelodami, which antagonized the growth of Mycobacterium tuberculosis, was shown to produce at least two antibiotic substances. A liquid medium was developed for their production, and cultural and assay procedures were defined. The antibiotics appear to be distinct from previously described derivatives of the true fungi and were named Amodin A and Amodin B. Both are active against certain Grampositive and acid-fast organisms, but Amodin B has the wider antibiotic spectrum and is active against some Gram-negative organisms and strains of Candida albicans. Amodin A was produced in surface and submerged cultures, but in better yield in the latter; it was extracted and prepared as a crude product. It appears to be a moderately heat-labile peptide; though non-toxic to mice it did not prolong their survival when infected with Staphylococcus aureus or M . tuberculosis a t the dosage of antibiotic used. Amodin B appeared only in surface cultures and was mainly present in the mycelium, from which it was liberated by dilute acid. It is relatively heatstable and not inactivated by proteolytic enzymes. Amodin A production appears to be linked with the conidial mode of sporulation and Amodin B with the perithecial mode.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Zone diameters were measured after incubation at 32" for 18-24 hr. Results were calculated according to standard statistical procedure for the evaluation of 4-point assays (Burn, Finney & Goodwin, 1950). Often the same solution gave $larger zone on one side of a plate than the other, due to inequality of agar depth.…”

Section: Methodsmentioning

confidence: 99%

Antibiotics from Aspergillus amstelodami

Darling

Campbell

McArdle

1963

Journal of General Microbiology

View full text Add to dashboard Cite

show abstract

“…Further, Sclerotium rolfsii was found susceptible to Trichoderma lingorum (Tode) Harz. and the antibiotic substance produced by above fungus was identified as viridine (Brain, 1951). Sychev and Shadoshinik (1982) found that T. viridae inhibited the growth of Rhizoctonia solani and F. oxysporum.…”

Section: Issn: 2319-7706 Volume 6 Number 4 (2017) Pp 2315-2327mentioning

confidence: 99%

Comparative Efficiency of Biocontrol Agents in the Management of Root Borne Diseases of Coleus (Coleus forskohlii (Willd.) Briq.)

Sreeramulu¹

2017

Int.J.Curr.Microbiol.App.Sci

View full text Add to dashboard Cite

“…I n general, it is considered that the Phycomycetes build up relatively simple metabolic products only and that they are not capable of synthesizing the complex molecules characteristic of so many antibiotics (Brian, 1951). In fact, the only reports of antibiotic activity from this group which we have found are those of Jefferys, Brian, Hemming & Lowe (1953) and of Miller & Porter (1956-7).…”

mentioning

confidence: 87%

Ramycin: A New Antibiotic

Dijck¹,

Somer²

1958

Journal of General Microbiology

View full text Add to dashboard Cite

SUMMARY: A strain of nlucor ramannianus from Campine forest soil was found to secrete an antibiotic, for which the name Ramycin is proposed. It is especially active against Gram-positive micro-organisms and Myobacterium tuberculosis H37Rv, but sensitive organisms quickly acquire resistance to it. Although it is not very toxic, it possesses a necrotic action on tissues. Ramycin can protect mice against streptococcal and staphylococcal infections but not against H 37 Rv.Ramycin crystallizes in orthorhombic plates. The new antibiotic is an opticallyinactive unsaturated hydroxy acid, containing C, H and 0 only.

show abstract

Antibiotics produced by fungi

Cited by 90 publications

References 181 publications

Antibiotics from Aspergillus amstelodami

Antibiotics from Aspergillus amstelodami

Comparative Efficiency of Biocontrol Agents in the Management of Root Borne Diseases of Coleus (Coleus forskohlii (Willd.) Briq.)

Ramycin: A New Antibiotic

Contact Info

Product

Resources

About