Antibiotics from Aspergillus amstelodami

Abstract

SUMMARYA strain of Aspergillus amstelodami, which antagonized the growth of Mycobacterium tuberculosis, was shown to produce at least two antibiotic substances. A liquid medium was developed for their production, and cultural and assay procedures were defined. The antibiotics appear to be distinct from previously described derivatives of the true fungi and were named Amodin A and Amodin B. Both are active against certain Grampositive and acid-fast organisms, but Amodin B has the wider antibiotic spectrum and is active against some Gram-negative organisms and strains of Candida albicans. Amodin A was produced in surface and submerged cultures, but in better yield in the latter; it was extracted and prepared as a crude product. It appears to be a moderately heat-labile peptide; though non-toxic to mice it did not prolong their survival when infected with Staphylococcus aureus or M . tuberculosis a t the dosage of antibiotic used. Amodin B appeared only in surface cultures and was mainly present in the mycelium, from which it was liberated by dilute acid. It is relatively heatstable and not inactivated by proteolytic enzymes. Amodin A production appears to be linked with the conidial mode of sporulation and Amodin B with the perithecial mode.

Bio-Guided Fractionation of Prenylated Benzaldehyde Derivatives as Potent Antimicrobial and Antibiofilm from Ammi majus L. Fruits-Associated Aspergillus amstelodami

“…In this study, A. amstelodami was isolated as endophytic fungi and to the best of our knowledge; this is the first report on the activity of A. amstelodami extract isolated from the A. majus fruits. However, endophytic fungi from genus Aspergillus have been stated as a source of bioactive secondary metabolites having diverse applications [36,37,38]. Bioactive metabolites derived from endophytic fungi revealed antimicrobial activity against a variety of organisms [13,14].…”