Oswaldo Cruz

Chagas, Carlos

doi:10.1590/s0074-02761916000200001

Cited by 5 publications

(4 citation statements)

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“…Carlos Chagas (1909) first observed the cystic forms of Pneumocystis in the lungs of rats and guinea pigs. Vanek and Jirovec (1952) first described Pneumocystis as an aetiological agent of endemic pneumonia in children.…”

Section: Pneumocystismentioning

confidence: 99%

Veterinary Mycology

Samanta

2015

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Section: Pneumocystismentioning

confidence: 99%

Veterinary Mycology

Samanta

2015

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“…Chronic Chagas' heart disease (cChHD) is the most frequent and severe clinical consequence of infection with Trypanosoma cruzi [1]. The mechanisms responsible for the cardiomyopathy are not clearly understood, but the occurrence of chronic myocardial injury in the near absence of parasites suggests an autoimmune mechanism [2].…”

Section: Introductionmentioning

confidence: 99%

Correlation between conformation and antibody binding: NMR structure of cross‐reactive peptides from T. cruzi, human and L. braziliensis

et al. 2004

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The structure of peptides corresponding to the C-terminal residues from Trypanosoma cruzi (R13), human (H13) and Leishmania braziliensis (A13) ribosomal proteins were determined using nuclear magnetic resonance. Although there is only one amino acid di¡erence between them, the peptides present distinct structures in solution: R13 adopts a random coil conformation while H13 and A13 form a bend. Interaction of these peptides with polyclonal antibodies from chronic Chagas' disease patients and a monoclonal antibody raised against T. cruzi ribosomal P2L L protein was probed by transferred NOE. The results show that the £exibility of R13 is fundamental for the binding to the antibody. ß 2004 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

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“…Chagas observed such forms in the lungs of guinea pigs inoculated with the blood of two children with trypanosomiasis. He misidentified them as a new schizogonic state of Trypanosoma cruzi and proposed a new trypanosome genus named Schizotrypanum (Chagas, 1909). Chagas observed the same cystic forms in the lungs of a human case of acute American trypanosomiasis (Chagas, 1911;Delaporte, 1999).…”

Section: The Pneumocystis Genus: From Protoctists To Fungimentioning

confidence: 99%

Pneumocystis: from a doubtful unique entity to a group of highly diversified fungal species

Chabé

Aliouat-Denis

Delhaès

et al. 2010

FEMS Yeast Research

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At the end of the 20th century the unique taxonomically enigmatic entity called Pneumocystis carinii was identified as a heterogeneous group of microscopic Fungi, constituted of multiple stenoxenic biological entities largely spread across ecosystems, closely adapted to, and coevolving in parallel with, mammal species. The discoveries and reasoning that led to the current conceptions about the taxonomy of Pneumocystis at the species level are examined here. The present review also focuses on the biological, morphological and phylogenetical features of Pneumocystis jirovecii, Pneumocystis oryctolagi, Pneumocystis murina, P. carinii and Pneumocystis wakefieldiae, the five Pneumocystis species described until now, mainly on the basis of the phylogenetic species concept. Interestingly, Pneumocystis organisms exhibit a successful adaptation enabling them to dwell and replicate in the lungs of both immunocompromised and healthy mammals, which can act as infection reservoirs. The role of healthy carriers in aerial disease transmission is nowadays recognized as a major contribution to Pneumocystis circulation, and Pneumocystis infection of nonimmunosuppressed hosts has emerged as a public health issue. More studies need to be undertaken both on the clinical consequences of the presence of Pneumocystis in healthy carriers and on the intricate Pneumocystis life cycle to better define its epidemiology, to adapt existing therapies to each clinical context and to discover new drug targets.

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Oswaldo Cruz

Cited by 5 publications

References 0 publications

Veterinary Mycology

Veterinary Mycology

Correlation between conformation and antibody binding: NMR structure of cross‐reactive peptides from T. cruzi, human and L. braziliensis

Pneumocystis: from a doubtful unique entity to a group of highly diversified fungal species

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