Quimiossensibilidade durante exercício na insuficiência cardíaca: respostas ventilatórias, cronotrópicas e neurohormonais

Moura, Lídia Zytynski; Guimarães, Guilherme Veiga; Pires, Philippe Vieira; Cruz, Fátima; Stopa, Gabriela; Bocchi, Edimar Alcides

doi:10.1590/s0066-782x2010005000110

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…It is a coincidence that previous studies have also evidenced that exercise can lead to aldosterone secretion [14] , [37] , [38] . We had detected the levels of plasma ACTH and plasma corticosterone, where the stress hormones were secreted from anterior pituitary and adrenal cortex, respectively, and found that swimming for 10 min in male rats resulted in an increase of plasma ACTH and plasma corticosterone level by 4.9-fold and 3.5-fold ( Fig.…”

Section: Discussionmentioning

confidence: 89%

Effect of Swimming on the Production of Aldosterone in Rats

Lieu

Lin²,

Wang

et al. 2014

PLoS ONE

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It has been demonstrated that exercise is one of the stresses known to increase the aldosterone secretion. Both potassium and angiotensin II (Ang II) levels are shown to be correlated with aldosterone production during exercise, but the mechanism is still unclear. In an in vivo study, male rats were catheterized via right jugular vein (RJV), and divided into four groups namely water immersion, swimming, lactate infusion (13 mg/kg/min) and pyruvate infusion (13 mg/kg/min) groups. Each group was treated for 10 min. Blood samples were collected at 0, 10, 15, 30, 60 and 120 min from RJV after administration. In an in vitro study, rat zona glomerulosa (ZG) cells were challenged by lactate (1–10 mM) in the presence or absence of Ang II (10−8 M) for 60 min. The levels of aldosterone in plasma and medium were measured by radioimmunoassay. Cell lysates were analyzed by immunoblotting assay. After exercise and lactate infusion, plasma levels of aldosterone and lactate were significantly higher than those in the control group. Swimming for 10 min significantly increased the plasma Ang II levels in male rats. Administration of lactate plus Ang II significantly increased aldosterone production and enhanced protein expression of steroidogenic acute regulatory protein (StAR) in ZG cells. These results demonstrated that acute exercise led to the increase of both aldosterone and Ang II secretion, which is associated with lactate action on ZG cells and might be dependent on the activity of renin-angiotensin system.

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Section: Discussionmentioning

confidence: 89%

Effect of Swimming on the Production of Aldosterone in Rats

Lieu

Lin²,

Wang

et al. 2014

PLoS ONE

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“…In the last three years, we selected five original contributions, regardless of the studies' areas of investigation. During this period, the award was presented to three original articles in the area of arterial hypertension [1][2][3] , three articles on heart failure and cardiomyopathies [4][5][6] , three articles related to cardiovascular surgery [7][8][9] , two articles in basic and experimental research 10,11 , and one article in the areas of arrhythmia 12 , epidemiology 13 , exercise and rehabilitation 14 and coronary failure 15 , respectively.…”

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confidence: 99%

Prêmio ABC de publicação científica e a produção científica nacional em cardiologia

Moreira¹

2011

Arq. Bras. Cardiol.

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Effects of the Recombinant Form of the Natural Human B‐type Natriuretic Peptide and Levosimendan on Pulmonary Hyperventilation and Chemosensivity in Heart Failure

Bocchi

Moura

Issa

et al. 2011

Cardiovascular Therapeutics

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SUMMARY Background:The origin of dyspnea in chronic heart failure (HF) is multifactorial, and excessive ventilation is thought to play a role in inducing this symptom. Chemosensivity is augmented in HF, correlates with increased pulmonary ventilation (VE), and is an adverse prognostic marker. Despite increased blood levels of natriuretic peptides in clinical conditions associated with dyspnea, their effect on pulmonary VE and chemoreceptor activity remains unexplored. Methods: We tested in a prospective, placebo-controlled, three-way cross-over, double-blind randomized study the effects of the recombinant form of the natural human B-type natriuretic peptide (R-BNP) in comparison with placebo and levosimendan on chemoreflex sensitivity at rest, as well as their effects on pulmonary VE, systemic blood pressure, heart rate and sympathetic serum activity both at rest and during exercise. Results: Eleven stable chronic HF patients were randomized to sessions of 6-min treadmillwalking tests during placebo, or levosimendan or R-BNP intravenous infusion in the following conditions: room air, hypoxia, and hypercapnia. R-BNP administration determined higher pulmonary ventilatory response at rest and during exercise (P < 0.001) consequent to a boost of respiratory rate (P < 0.001) under room air and hypoxia conditions. Norepinephrine blood levels increased from rest to exercise in all conditions without differences among placebo, levosimendan, and R-BNP effects. BNP blood levels remained unchanged. Conclusions:The novelty of the present findings is that R-BNP infusion in HF patients can boost pulmonary ventilatory response at rest and during exercise.

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Quimiossensibilidade durante exercício na insuficiência cardíaca: respostas ventilatórias, cronotrópicas e neurohormonais

Abstract: ResumenFundamento: Heart failure (HF) is associated with resting increased peripheral and central chemosensitivity which may correlate with an increased ventilatory response to exercise. However, its sensitivity in HF during exercise was never really reported.

Cited by 4 publications

References 35 publications

Effect of Swimming on the Production of Aldosterone in Rats

Effect of Swimming on the Production of Aldosterone in Rats

Prêmio ABC de publicação científica e a produção científica nacional em cardiologia

Effects of the Recombinant Form of the Natural Human B‐type Natriuretic Peptide and Levosimendan on Pulmonary Hyperventilation and Chemosensivity in Heart Failure

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