Efeito do bisoprolol sobre a função cardíaca e o exercício em pacientes com insuficiência cardíaca

Abstract

SummaryObjectives: To assess the effects of bisoprolol on exercise capacity and ventricular function in patients with heart failure.Methods: Clinical and hemodynamic variables, ventricular function and remodeling, and ergospirometry of patients with heart failure of different etiologies were evaluated before and after the administration of bisoprolol.Results: Twenty-two patients were analyzed; one patient did not tolerate medication and 14 patients reached the study goal. The group consisted of 9 men and 5 women, the mean age was 52 (36-64) years, and patients were followed during 551 days (238-1109). We observed an improvement in NYHA functional class, reduction in resting heart rate (78.8±8.7 vs 63±6.4 bpm, p <0.001), increase in left ventricular ejection fraction (31.3±8.5% vs 39±14.7%. p=0.043), and a tendency towards improved quality of life scores (31±20.6 vs 17.8±14.8. p=0.058). The maximum heart rate dropped during exercise (138.1±20.2 vs 116.7±27.1. p=0.01), as did peak oxygen consumption (20.9±6.8 vs 15.1±3.5. p<0.001); no change was observed on the EV/VCO2 slope. The effects were observed for all etiologies, including Chagas' disease.Conclusion: Bisoprolol was safe and well tolerated in patients with heart failure. Bisoprolol therapy improved the symptoms, hemodynamic variables, as well as the cardiac function for all etiologies; however, it did not result in improved exercise capacity.

Divergent effect of adrenaline in human induced pluripotent stem cell derived cardiomyocytes obtained from hypertrophic cardiomyopathy

“…Bisoprolol is a selective β1-adrenoceptor blocker ( Brixius et al, 2001 ) and has been used to improve exercise capacity in heart failure ( Issa et al, 2007 ; Dubach et al, 2002 ). In another clinical study on heart failure, bisoprolol reduced heart rate and increased the heart rate variability parameter ( Pousset et al, 1996 ).…”

Heart Failure in South America

“…Recommendations of Guidelines for Treatment of Heart Failure due to Chagas´heart disease in general is similar to other etiologies, but with low degree of evidences [76, 77]. There is no evidence for specific agent treatment for chagasic heart failure [78].…”

Recent Trends in Brazilian Medical Research. An Overview

“…Nascimento et al20 find that the midazolan was associated with a greater sedative and cardiovascular effect than diazepam in patients undergoing hemodynamic studies for suspected coronary artery disease. Issa et al21 found that bisoprolol was found to be safe and well tolerated in patients with heart failure, improved symptoms, hemodynamic variables, as well as the cardiac function for all etiologies of heart failure, but did not result in improved exercise capacity. Azevedo et al22 described cardiac and metabolic characteristics of long distance runners.…”