Controle microbiológico em valvas cardíacas humanas

Abstract

From the Analysis of the results, it was observed the importance of microbiological control in human grafts, in order to avoid using microbiologically contaminated valves in patients submitted to cardiovascular surgery.

Disinfection of human cardiac valve allografts in tissue banking: systematic review report

“…Villalba et al (2009) added an antibiotic cocktail composed of amikacin (50 µg/ml), vancomycin (50 µg/ml), metronidazole (50 µg/ml), and amphotericin B 5ug/ml and effectively reduced the number of contaminated tissues to 3.2 %, although the initial number of contaminated tissues was not reported (Villalba et al 2009). Peruzzo et al (2006) disinfected  the tissue samples with cefoxitin (240 µg/ml), lincomycin (120 µg/ml), polymyxin B (100 µg/ml), and vancomycin (50 µg/ml), and were able to reduce the proportion of allografts discarded from 8 to 5.6 % (Peruzzo et al 2006). Both reports included a combination of broad-spectrum antibiotics as well as an anti-fungal agent.…”

Estudo experimental comparativo do enxerto homólogo pulmonar tratado pelo processo L-Hydro com o homoenxerto pulmonar a fresco

“…Even thus, some problems remain, such as the cost, sophistication of the method, the difficulty of eliminating infectious agents [6], and the degeneration in the long term [1,7,8]. Other processes, such as decellularization are under development with contradictory outcomes.…”