I Diretriz de Prevenção da Aterosclerose na Infância e na Adolescência

doi:10.1590/s0066-782x2005002500001

Cited by 75 publications

(19 citation statements)

References 86 publications

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“…Low-density lipoprotein cholesterol (LDL-C) was calculated. 9 The cut-offs for metabolic abnormalities were: total cholesterol ≥150 mg/dL, LDL-C ≥100 mg/dL, HDL-C <45 mg/dL, triglycerides >100 mg/dL, 22 and glucose ≥100 mg/dL. 8 Risk for cardiovascular disease was evaluated using two approaches.…”

Section: Methodsmentioning

confidence: 99%

Body mass index for predicting hyperglycemia and serum lipid changes in Brazilian adolescents

et al. 2009

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Índice de massa corporal para predizer hiperglicemia e alterações lipídicas em adolescentes brasileiros ABSTRACT OBJECTIVE: To determine the best cut-offs of body mass index for identifying alterations of blood lipids and glucose in adolescents. METHODS:A probabilistic sample including 577 adolescent students aged 12-19 years in 2003 (210 males and 367 females) from state public schools in the city of Niterói, Southeastern Brazil, was studied. The Receiver Operating Characteristic curve was used to identify the best age-adjusted BMI cut-off for predicting high levels of serum total cholesterol (≥150mg/dL), LDL-C (≥ 100mg/dL), serum triglycerides (≥100mg/dL), plasma glucose (>100mg/dL) and low levels of HDL-C (< 45mg/dL). Four references were used to calculate sensitivity and specifi city of BMI cut-offs: one Brazilian, one international and two American. RESULTS:The most prevalent metabolic alterations (>50%) were: high total cholesterol and low HDL-C. BMI predicted high levels of triglycerides in males, high LDL-C in females, and high total cholesterol and the occurrence of three or more metabolic alterations in both males and females (areas under the curve range: 0.59 to 0.67), with low sensitivity (57%-66%) and low specifi city (58%-66%). The best BMI cut-offs for this sample (20.3 kg/m² to 21.0 kg/m²) were lower than those proposed in the references studied. CONCLUSIONS:Although BMI values lower than the International cutoffs were better predictor of some metabolic abnormalities in Brazilian adolescents, overall BMI is not a good predictor of these abnormalities in this population.

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Section: Methodsmentioning

confidence: 99%

Body mass index for predicting hyperglycemia and serum lipid changes in Brazilian adolescents

et al. 2009

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“…Mean cholesterol levels for both groups were above the cutoff point recommended to define the normality range for children and adolescents in Brazil. This fact is alarming because ours was a young population and this lipoprotein profile places it at high risk for atherosclerosis development [48]. …”

Section: Discussionmentioning

confidence: 99%

“…The mechanism explaining this association may be the activation of AMP-dependent kinase, induced by the increase in insulin and leptin and reduced activation of adiponectin, which in turn increases the oxidation of fatty acids [48]. Such associations between IR and dyslipidemia justifies starting prevention in childhood or adolescence.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Syndrome in Overweight and Obese Adolescents: A Comparison of Two Different Diagnostic Criteria

2014

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Background: Due to the lack of consensus on its definition, the metabolic syndrome (MS) in children and adolescents is not formally recognized. However, several researchers have changed the adult criteria for pediatric standards in order to assess the prevalence. Objective: The aim of this study was to evaluate the frequency of MS and its components according to two of the currently used definitions in overweight and obese adolescents. Methods: A cross-sectional study with 232 adolescents with excess weight from a public school of the city of Rio de Janeiro. Anthropometric, blood pressure, and biochemical variables were assessed. MS was defined using two different diagnostic criteria: the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII) and International Diabetes Federation (IDF). Results: MS was diagnosed in 40.4 and 24.6% of obese adolescents and 9.4 and 1.9% of overweight adolescents according to the NCEP-ATPIII and IDF criteria, respectively. The degree of agreement, assessed by the κ index, from the definitions adopted in this study was 0.48. Conclusion: The results show a significant difference between the two diagnostic criteria. A higher frequency was found when the NCEP-ATPIII was used, which is of concern given the association of MS with diabetes and cardiovascular disease.

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“…Nas meninas, observa-se um aumento progressivo do HDL a partir dos 10 anos, o qual é marcadamente superior ao dos meninos no final da adolescência. Também o LDL e o CT se elevam progressivamente a partir dos 14-15 anos nas meninas, sendo superiores aos dos meninos por volta dos 17-18 anos 3 .…”

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Dislipidemia em crianças e adolescentes do município de Marau-RS

et al. 2019

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Resumo Introdução As doenças cardiovasculares são consideradas um dos principais problemas de saúde na atualidade. O perfil lipídico de crianças e adolescentes se associa diretamente com a prevalência de doença coronariana em adultos, pois o processo aterosclerótico começa a se desenvolver na juventude e progride na vida adulta. Objetivo Avaliar o perfil lipídico de crianças e adolescentes da cidade de Marau-RS. Método Realizou-se um estudo retrospectivo, no qual foi avaliado o perfil lipídico de crianças e adolescentes de 1 a 19 anos, período de abril de 2016 a julho 2017, totalizando 272 pacientes. Resultados Entre os pacientes analisados, 34,7% apresentaram hipercolesterolemia, 56,7% demonstraram níveis de HDL abaixo do desejável, 16% exibiram níveis de LDL aumentado e 16% tinham hipertrigliceridemia. A análise estatística dos resultados mostrou uma concentração de colesterol total, HDL e triglicerídeos significativamente mais alta em meninas do que em meninos. Conclusão O percentual elevado de dislipidemias na infância aponta para a necessidade de implantação de políticas públicas que previnam a dislipidemia juvenil, minimizando, assim, agravos relacionados a doenças cardiovasculares na vida adulta da população.

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I Diretriz de Prevenção da Aterosclerose na Infância e na Adolescência

Cited by 75 publications

References 86 publications

Body mass index for predicting hyperglycemia and serum lipid changes in Brazilian adolescents

Body mass index for predicting hyperglycemia and serum lipid changes in Brazilian adolescents

Metabolic Syndrome in Overweight and Obese Adolescents: A Comparison of Two Different Diagnostic Criteria

Dislipidemia em crianças e adolescentes do município de Marau-RS

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