Parto prematuro após uso de antimonial pentavalente: relato de um caso

Silveira, Bruna Pinheiro; Sobrinho, José Araújo; Leite, Lacínia Freire; Sales, Maria das Neves Andrade; Gouveia, Maria; Mathias, Renato Leal; Filho, Ricardo Amorim Guedes; Barbosa, Sônia Maria

doi:10.1590/s0037-86822003000400016

Cited by 13 publications

(5 citation statements)

References 5 publications

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“…There were 2 (2.2%) miscarriages, 2 (2.2%) pre-term births, and 1 (1.1%) required splenectomy after delivery due to poor recovery and due to persistence of parasitaemia in the spleen sample ( Table 3 ) [ 54 ]. There were 3 foetal deaths reported; one of the babies died due to myelomeningocele 3 hours after birth [ 12 ], another died a day after being born [ 55 ], and another died due to VL at 2 months [ 12 ]. Further details are presented in Table 3 .…”

Section: Resultsmentioning

confidence: 99%

Visceral Leishmaniasis in pregnancy and vertical transmission: A systematic literature review on the therapeutic orphans

et al. 2021

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Background Reports on the occurrence and outcome of Visceral Leishmaniasis (VL) in pregnant women is rare in published literature. The occurrence of VL in pregnancy is not systematically captured and cases are rarely followed-up to detect consequences of infection and treatment on the mother and foetus. Methods A review of all published literature was undertaken to identify cases of VL infections among pregnant women by searching the following database: Ovid MEDLINE; Ovid Embase; Cochrane Database of Systematic Reviews; Cochrane Central Register of Controlled Trials; World Health Organization Global Index Medicus: LILACS (Americas); IMSEAR (South-East Asia); IMEMR (Eastern Mediterranean); WPRIM (Western Pacific); ClinicalTrials.gov; and the WHO International Clinical Trials Registry Platform. Selection criteria included any clinical reports describing the disease in pregnancy or vertical transmission of the disease in humans. Articles meeting pre-specified inclusion criteria and non-primary research articles such as textbook, chapters, letters, retrospective case description, or reports of accidental inclusion in trials were also considered. Results The systematic literature search identified 272 unique articles of which 54 records were included in this review; a further 18 records were identified from additional search of the references of the included studies or from personal communication leading to a total of 72 records (71 case reports/case series; 1 retrospective cohort study; 1926–2020) describing 451 cases of VL in pregnant women. The disease was detected during pregnancy in 398 (88.2%), retrospectively confirmed after giving birth in 52 (11.5%), and the time of identification was not clear in 1 (0.2%). Of the 398 mothers whose infection was identified during pregnancy, 346 (86.9%) received a treatment, 3 (0.8%) were untreated, and the treatment status was not clear in the remaining 49 (12.3%). Of 346 mothers, Liposomal amphotericin B (L-AmB) was administered in 202 (58.4%) and pentavalent antimony (PA) in 93 (26.9%). Outcomes were reported in 176 mothers treated with L-AmB with 4 (2.3%) reports of maternal deaths, 5 (2.8%) miscarriages, and 2 (1.1%) foetal death/stillbirth. For PA, outcomes were reported in 88 mothers of whom 4 (4.5%) died, 24 (27.3%) had spontaneous abortion, 2 (2.3%) had miscarriages. A total of 26 cases of confirmed, probable or suspected cases of vertical transmission were identified with a median detection time of 6 months (range: 0–18 months). Conclusions Outcomes of VL treatment during pregnancy is rarely reported and under-researched. The reported articles were mainly case reports and case series and the reported information was often incomplete. From the studies identified, it is difficult to derive a generalisable information on outcomes for mothers and babies, although reported data favours the usage of liposomal amphotericin B for the treatment of VL in pregnant women.

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Section: Resultsmentioning

confidence: 99%

Visceral Leishmaniasis in pregnancy and vertical transmission: A systematic literature review on the therapeutic orphans

et al. 2021

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“…Pelo menos mais dois casos foram descritos posteriormente, uma mulher de 19 anos, natural de Pombal (PB), procedente de Carfanaum (BA) 12 , e outra de 18 anos, natural e procedente de Campo Grande (MS). 13 O presente trabalho relata o caso de uma gestante adolescente -a mais jovem dos casos relatados no Brasil -com leishmaniose visceral, residente em Jacobina (BA), com 15 anos, que vive em condições de extrema pobreza. A garantia da confidencialidade do caso foi assumida pelos autores, e a responsável pela menor assinou o termo de consentimento pós-informação.…”

Section: Introductionunclassified

Leishmaniose visceral em adolescente gestante

Vieira¹,

Jacobina²,

Soares³

2007

cmbio

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A leishmaniose visceral (LV) é uma doença típica dos países subdesenvolvidos. Atualmente, encontra-se entre as seis endemias consideradas prioritárias no mundo. A cidade de Jacobina, no Estado da Bahia, Brasil, é uma área de elevada endemicidade e, nos últimos anos, vem aumentado o número de casos principalmente na periferia da cidade, atingindo inclusive gestantes. No presente trabalho, é relatado um caso clínico de uma gestante adolescente de 15 anos, portadora de leishmaniose visceral, que não foi tratada durante a gestação, e a criança foi a óbito com dois meses, pesando 1,8 Kg, sem confirmação da transmissão congênita.

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“…Os antimoniais pentavalentes atravessam a barreira placentária podendo causar impregnação neural, ocasionando os mais variados graus de retardo mental no RN 3,4,12,13 . Há um relato de parto pré-termo após uso do antimonial em gestante com LV 14 .…”

Section: Relato De Casounclassified

“…Thakur et al 16 Gradoni et al 7 Utili et al 17 Kumar et al 15 Viana et al 9 Silveira et al 14 Em nosso relato, a gestante estava no início do terceiro trimestre da gestação, quando do diagnóstico, sendo tratada com anfotericina B lipossomal 1 mg/kg/dia, respeitando a dose máxima de 50 mg/dia, em solução glicosada a 5% endovenosa em 2 horas por 21 dias, com bom resultado clínico e laboratorial, sem intercorrências. A escolha baseou-se nas referências da literatura, que mostram menor toxicidade deste medicamento.…”

Section: Referênciaunclassified

Leishmaniose visceral e gestação: relato de caso

Filho

Uehara

Senefonte

et al. 2005

Rev. Bras. Ginecol. Obstet.

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RESUMOLeishmaniose visceral (LV) é doença endêmica no Estado de Mato Grosso do Sul, Brasil, principalmente nas áreas próximas dos rios Paraguai e Paraná. Nos últimos anos vem aumentando o número de casos, especialmente na Capital, Campo Grande, com conseqüente surgimento de casos em gestantes e conseqüentemente havendo risco de transmissão vertical do parasita. No presente trabalho é relatado um caso de LV em gestante, acompanhada por nosso grupo e tratada com anfotericina B lipossomal, não tendo ocorrido a transmissão vertical do parasita. O presente relato demonstra opção terapêutica em casos de calazar durante a gestação, tendo em vista a contra-indicação relativa do uso do antimoniato, droga de primeira escolha para tratamento em pacientes não-gestantes. ABSTRACTVisceral leishmaniasis (VL) is an endemic disease in the state of Mato Grosso do Sul, Brazil, mainly in the areas near the Paraguay and Paraná rivers. An increasing number of cases have been occurring especially in the state capital Campo Grande, with consequent occurrence of VL cases in pregnant women. This situation causes an elevated risk of vertical transmission of the parasite. In this report, we describe a case of VL in a pregnant woman followed up by our group, who was treated with liposomal amphotericin B, with no vertical transmission of the parasite. In our report, we demonstrate a therapeutic option for kala-azar during pregnancy, since antimoniate, the first-choice drug, is not prescribed during the gestational period.

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Parto prematuro após uso de antimonial pentavalente: relato de um caso

Cited by 13 publications

References 5 publications

Visceral Leishmaniasis in pregnancy and vertical transmission: A systematic literature review on the therapeutic orphans

Visceral Leishmaniasis in pregnancy and vertical transmission: A systematic literature review on the therapeutic orphans

Leishmaniose visceral em adolescente gestante

Leishmaniose visceral e gestação: relato de caso

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