A case is reported of a 19-year-old woman, at week 24 of gestation, with visceral leishmaniosis. She was treated with meglumine antimoniate at a dose of 850 mg/day for 20 days. There occurred premature birth on day five of treatment and the neonate died one day after birth. Considering the importance of protozoiasis in our population and the rarity of the association with pregnancy, we resolved to publish the case.
Schizencephaly is an uncommon structural disorder of cerebral cortical development. There are few comparative studies evaluating epilepsy in that condition. The aim of this study is to analyze which factors are associated with the development of epilepsy in patients with schizencephaly. The study is a longitudinal, observational and comparative retrospective study of 35 pediatric patients with schizencephaly. The patients were divided into two groups: a group of 10 children who developed epilepsy and another group of 25 who had no clinical epileptic manifestations. Both groups were followed up and the data collected to analyze potential risk factors included demographic and prenatal data (prenatal event, family history of epilepsy), radiological features (location of the cleft, unilateral or bilateral, extent of the lesion, number of impaired lobes, open-lip or closed-lip types, presence of associated anomalies), and neurological and electroencephalographic data. No significant difference was found in the association between epilepsy and any of the examined factors (P > 0.05). Neither the features of the lesion (cleft size location, type of lip, number of impaired lobes, associated anomalies), nor electroencephalography abnormalities, nor the family history of epilepsy or prenatal events could predict the occurrence of epilepsy in patients with schizencephaly.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.