Cecílio Romaña, o sinal de Romaña e a doença de Chagas

Dias, João Carlos Pinto

doi:10.1590/s0037-86821997000500012

Cited by 23 publications

(9 citation statements)

References 2 publications

(1 reference statement)

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“…Romaña’s sign or ‘chagoma’ is the earliest sign of T. cruzi infection in a proportion of naturally infected individuals and is characterized by an intense mononuclear infiltrate at the site of infection (35). The molecular basis of this intense response is well understood but studies suggest that T. cruzi can stimulate the host’s cutaneous cells to produce mediators that will trigger a local inflammatory response.…”

Section: Toll-like Receptorsmentioning

confidence: 99%

Pathogenesis of Chagas disease: time to move on

Machado¹,

Brant

Esper

et al. 2012

Front Biosci

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Trypanosoma cruzi is the etiologic agent of Chagas disease. The contributions of parasite and immune system for disease pathogenesis remain unresolved and controversial. The possibility that Chagas disease was an autoimmune progression triggered by T. cruzi infection led some to question the benefit of treating chronically T. cruzi-infected persons with drugs. Furthermore, it provided the rationale for not investing in research aimed at a vaccine which might carry a risk of inducing autoimmunity or exacerbating inflammation. This viewpoint was adopted by cash-strapped health systems in the developing economies where the disease is endemic and has been repeatedly challenged by researchers and clinicians in recent years and there is now a considerable body of evidence and broad consensus that parasite persistence is requisite for pathogenesis and that antiparasitic immunity can be protective against T. cruzi pathogenesis without eliciting autoimmune pathology. Thus, treatment of chronically infected patients is likely to yield positive outcomes and efforts to understand immunity and vaccine development should be recognized as a priority area of research for Chagas disease.

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Section: Toll-like Receptorsmentioning

confidence: 99%

Pathogenesis of Chagas disease: time to move on

Machado¹,

Brant

Esper

et al. 2012

Front Biosci

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show abstract

“…Such interaction sometimes produces visible signs called Romaña's sign or chagoma inoculation. The histology of this initial site of infection is defined by an elevated number of mononuclear cells [1]. This first sign of infection suggests that T. cruzi can stimulate skin cells to produce mediators that trigger a local inflammatory response.…”

Section: Immune Response To Trypanosoma Cruzi Infection In the Vermentioning

confidence: 99%

Lysophosphatidylcholine: A Novel Modulator ofTrypanosoma cruziTransmission

Silva-Neto

Carneiro

Silva-Cardoso

et al. 2012

Journal of Parasitology Research

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Lysophosphatidylcholine is a bioactive lipid that regulates a large number of cellular processes and is especially present during the deposition and infiltration of inflammatory cells and deposition of atheromatous plaque. Such molecule is also present in saliva and feces of the hematophagous organism Rhodnius prolixus, a triatominae bug vector of Chagas disease. We have recently demonstrated that LPC is a modulator of Trypanosoma cruzi transmission. It acts as a powerful chemoattractant for inflammatory cells at the site of the insect bite, which will provide a concentrated population of cells available for parasite infection. Also, LPC increases macrophage intracellular calcium concentrations that ultimately enhance parasite invasion. Finally, LPC inhibits NO production by macrophages stimulated by live T. cruzi, and thus interferes with the immune system of the vertebrate host. In the present paper, we discuss the main signaling mechanisms that are likely used by such molecule and their eventual use as targets to block parasite transmission and the pathogenesis of Chagas disease.

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“…En ese marco, la importancia de la enfermedad aumentaba a medida que crecía la recopilación de "casos agudos", que se vio favorecida por la identificación del "Signo de romaña" -inflamación del párpado como reacción ante la picadura de la vinchuca-que favoreció enormemente la difusión de la enfermedad entre los médicos no expertos (2,9,16,17,18). Y hacia fines de la década de 1930, la enfermedad comenzaba a ser reconocida como un problema sanitario de envergadura por parte del campo científico-médico, sustentado en la acumulación de casos certificados y en las intensas actividades de divulgación de mazza y sus colaboradores.…”

Section: Descubrimiento Redefinición Y Desaparición De La Enfermedadunclassified

La enfermedad en su laberinto: avances, desafíos y paradojas de cien años del Chagas en Argentina

Zabala¹

2012

Salud Colectiva

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ArtíCuLo / ArTiClE resumen El artículo analiza la persistencia de la enfermedad de Chagas en la Argentina durante más de un siglo, prestando atención a las diferentes dimensiones (biológica, de conocimiento, política, profesional y técnica) que participan en su definición. Se pone el acento en la identificación y discusión de algunas de las tensiones fundamentales que han marcado la historia de la enfermedad, con la intención de discutir cuáles han sido los condicionamientos concretos que han marcado, por un lado, la continuidad de la enfermedad dentro de la consideración política pero, al mismo tiempo, la imposibilidad de alcanzar una situación de control definitivo.

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Cecílio Romaña, o sinal de Romaña e a doença de Chagas

Cited by 23 publications

References 2 publications

Pathogenesis of Chagas disease: time to move on

Pathogenesis of Chagas disease: time to move on

Lysophosphatidylcholine: A Novel Modulator ofTrypanosoma cruziTransmission

La enfermedad en su laberinto: avances, desafíos y paradojas de cien años del Chagas en Argentina

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