Cromoblastomicose no Rio Grande do Sul: relato de 12 casos

Matte, Shirley M.W.; Lopes, Jorge O.; Melo, Ivanir S.; Espadim, Luís Eduardo R.; Pinto, Maximiliano Soares

doi:10.1590/s0037-86821997000400006

Cited by 14 publications

(21 citation statements)

References 9 publications

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“…The evolution of the disease is slow and frequentely patients only seek for a doctor some years after the initial symptoms. 5 The segment of the body mostly affected were the lower limbs which is in accordance with the bibliographical revision, 1, 2, 4,6,7,9,10,11 although in some works other sites are more prevailing. 5,16 In underdeveloped countries, people work without equipmentsfor protection, favouring the direct contact with the fungi habitat.…”

Section: Discussionsupporting

confidence: 75%

“…5 The segment of the body mostly affected were the lower limbs which is in accordance with the bibliographical revision, 1, 2, 4,6,7,9,10,11 although in some works other sites are more prevailing. 5,16 In underdeveloped countries, people work without equipmentsfor protection, favouring the direct contact with the fungi habitat. 2 The predominant location of lesions on the lower limbs and history of previous local trauma is directly correlated with the type of activity performed and reinforces the hypothesis of traumatic implantation of the fungus in the tissues to produce such infection.…”

Section: Discussionsupporting

confidence: 75%

“…In Brazil, Rio Grande do Sul, São Paulo, Rio de Janeiro, Minas Gerais, and states from the Amazonian region are endemic areas. 5 The majority of 4,12,13 Age related to the begining of the lesions in men was lower than in women. We inferred that this is due to the fact that the begining of professional activity for men, most of the time, is more precocious, exposing them to the etiologic agents.…”

Section: Discussionmentioning

confidence: 97%

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Cromoblastomicose: relato de 27 casos e revisão da literatura

Correia

Valente

Criado

et al. 2010

An. Bras. Dermatol.

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BACKGROUND: Chromoblastomycosis is a subcutaneous mycosis that occurs mainly in rural workers although is being more commonly found among people working in other sectors. The fungus penetrates the skin after its inoculation and the most frequently isolated agent is the Fonsecaea pedrosoi. OBJECTIVES: This study aims at evaluating patients suffering from chromoblastomycosis admitted into the Department of Dermatology of the University Hospital of the Faculty of Medicine of São Paulo State during the ten-year period from 1997 to 2007. METHODS: It is a retrospective study and the medical report cards of 27 Brazilian patients diagnosed as suffering from Chromoblastomycosis from 1997 to 2007 at the Dermatology Department of the Medical School, University of Sao Paulo were reviewed. The following items were analyzed: previous therapeutic approaches; treatment implemented by the group; length of time between the appearing of the lesion and diagnosis; age; gender; profession; origin; site of lesions; isolated agents found in culture and histopathology. RESULTS: Twenty two patients were from the state of Sao Paulo whereas the others came from the states of Bahia and Rondonia. 37% of them were rural workers. Men were more frequently infected (85%). Lesions were more commonly found on the lower limbs (59.2%). In 52% of the cases the isolated agent was the dematiaceous fungus Fonsecaea. pedrosoi. Biopsies showed sclerotic bodies in 92.5% of the cases. CONCLUSION: Data found are in accordance with medical literature on the subject. The disease had been previously studied in our institution in 1983 by Cucé et al. This present study is the second retrospective one about the characteristics of patients suffering from chromoblastmycosis which has been published in indexed medical literature in the state of Sao Paulo. Keywords: Chromoblastomycosis; Epidemiology; Fungi Resumo: FUNDAMENTOS: A cromoblastomicose é uma micose subcutânea que acomete principalmente homens trabalhadores rurais, sendo cada vez mais observada em outras atividades profissionais. O fungo penetra na pele após inoculação, e o agente mais frequentemente isolado é a Fonsecaea pedrosoi. OBJETIVOS: Este estudo visa a avaliar os pacientes com cromoblastomicose admitidos no departamento de dermatologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo no período de 1997 a 2007. MÉTODOS: É um estudo retrospectivo, utilizando a revisão de prontuários, e inclui 27 pacientes. Analisaram-se os tratamentos prévios e os atuais instituídos, o tempo entre o aparecimento das lesões e o diagnóstico, a idade, o gênero, a profissão, a procedência, a localização das lesões e os agentes isolados em cultivo. RESULTADOS: Vinte e dois pacientes eram procedentes do estado de São Paulo. Os demais eram procedentes da Bahia e Rondônia. A maioria dos pacientes estudados eram trabalhadores rurais (37%). Os homens foram os mais acometidos (85%). A maior parte dos pacientes apresentava lesões nos membros inferiores (59,2%). Em 52% dos casos foi isolado ...

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Section: Discussionsupporting

confidence: 75%

Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 97%

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Cromoblastomicose: relato de 27 casos e revisão da literatura

Correia

Valente

Criado

et al. 2010

An. Bras. Dermatol.

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“…The lower limbs are the area of the body that would be most likely to be in contact with material contaminated by fungi. 1,3,7,9,10,11 The polymorphism of chromoblastomycosis lesions has attracted the attention of various authors simple visualization of the structures of the etiological agent is related to the fact that this is an infection in which the fungal elements are eliminated through the skin (transepidermal elimination); hence they can be obtained by simply scraping the lesions.…”

mentioning

confidence: 99%

Clinical, epidemiological and mycological report on 65 patients from the Eastern Amazon region with chromoblastomycosis

Pires

Xavier

Quaresma

et al. 2012

An. Bras. Dermatol.

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BACKGROUND: Chromoblastomycosis is a chronic fungal infection caused by fungi from the Dematiaceae family. According to several studies, Fonsecaea pedrosoi is the most common of these fungi. The infection is more common in tropical countries, with the Brazilian state of Pará having one of the largest infected populations worldwide. The disease is difficult to treat and recurrences are common. OBJECTIVES: To describe the epidemiological and mycological aspects of cases of chromoblastomycosis and its clinical forms in the state of Pará, Brazil. METHODS: Mycological exams (direct mycological examinations, culture and microculture) were performed and a clinical/epidemiological evaluation was made of 65 patients receiving care at the Dermatology Department of the Federal University of Pará between 2000 and 2007. The clinical classification proposed by Carrión in 1950 was used in this study. RESULTS: The majority of the patients were male (93.8%), agricultural workers (89.2%) of 45 to 55 years of age, and the majority of lesions (55.4%) were of the verrucous type, located principally on the lower limbs (81.5%). In the majority of the cases investigated (61.5%), the infection had been present for a long time, with a mean duration of 11 years. Direct mycological examination was performed in 86.2% of the patients (n=56). Of these, 96.4% (n=54) tested positive. Culture and microculture were performed in vitro in 47 cases of those that tested positive at direct microscopy, results showing Fonsecaea pedrosoi to be the only agent present in this sample. CONCLUSION: This study highlighted the extent to which chromoblastomycosis still affects the quality of life of the local population, principally individuals working in agriculture. This is a chronic disease for which there is no effective treatment. The importance of continuing to investigate this disease should be emphasized, as further studies may lead to new clinical or epidemiological findings.

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“…Chromoblastomycosis (CBM) is a chronic human melanized fungi infection of subcutaneous tissue caused by traumatic inoculation of a specific group of dematiaceous fungi (usually Fonsecaea pedrosoi or Cladophialophora carrionii) through the skin 1,14 . It has been described worldwide, but it is most commonly seen in tropical or subtropical climates 18 .…”

Section: Introductionmentioning

confidence: 99%

Treatment of severe chromoblastomycosis with itraconazole and 5-flucytosine association

Antonello

Silva

Cambruzzi

et al. 2010

Rev. Inst. Med. trop. S. Paulo

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SUMMARYChromoblastomycosis is a chronic human melanized fungi infection of the subcutaneous tissue caused by traumatic inoculation of a specific group of dematiaceous fungi through the skin, often found in barefooted agricultural workers, in tropical and subtropical climate countries. We report the case of a male patient presenting a slow-growing pruriginous lesion on the limbs for 20 years, mistreated over that time, which was diagnosed and successfully treated as chromoblastomycosis. Besides the prevalence of this disease, treatment is still a clinical challenge.

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Cromoblastomicose no Rio Grande do Sul: relato de 12 casos

Cited by 14 publications

References 9 publications

Cromoblastomicose: relato de 27 casos e revisão da literatura

Cromoblastomicose: relato de 27 casos e revisão da literatura

Clinical, epidemiological and mycological report on 65 patients from the Eastern Amazon region with chromoblastomycosis

Treatment of severe chromoblastomycosis with itraconazole and 5-flucytosine association

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