Treatment of severe chromoblastomycosis with itraconazole and 5-flucytosine association

Antonello, Vicente Sperb; Silva, Marcelo Campos Appel da; Cambruzzi, Eduardo; Kliemann, Dimas Alexandre; Santos, Breno; Queiroz‐Telles, Flávio

doi:10.1590/s0036-46652010000600008

Cited by 21 publications

(13 citation statements)

References 16 publications

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“…The main issue is that in most of the countries where CBM is present, 5-FC is not available. Moreover, patients need to take a large number of pills per day, resulting in more noncompliance (302)(303)(304).…”

Section: Combined Systemic Antifungal Treatmentmentioning

confidence: 99%

“…In addition, the PCZ oral solution is characterized by better pharmacodynamic and pharmacokinetic profiles than those of the ITZ capsule formulation. The recommended dose of the oral suspension of PCZ in patients with CBM is 800 mg/day divided into two doses for long periods of therapy (304). It is expected that in the future, recently licensed PCZ formulations, that is, oral tablets and intravenous solutions, may also be evaluated in PHM and CBM patients.…”

Section: Role Of Other Triazolesmentioning

confidence: 99%

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Chromoblastomycosis

et al. 2017

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SUMMARY Chromoblastomycosis (CBM), also known as chromomycosis, is one of the most prevalent implantation fungal infections, being the most common of the gamut of mycoses caused by melanized or brown-pigmented fungi. CBM is mainly a tropical or subtropical disease that may affect individuals with certain risk factors around the world. The following characteristics are associated with this disease: (i) traumatic inoculation by implantation from an environmental source, leading to an initial cutaneous lesion at the inoculation site; (ii) chronic and progressive cutaneous and subcutaneous tissular involvement associated with fibrotic and granulomatous reactions associated with microabscesses and often with tissue proliferation; (iii) a nonprotective T helper type 2 (Th2) immune response with ineffective humoral involvement; and (iv) the presence of muriform (sclerotic) cells embedded in the affected tissue. CBM lesions are clinically polymorphic and are commonly misdiagnosed as various other infectious and noninfectious diseases. In its more severe clinical forms, CBM may cause an incapacity for labor due to fibrotic sequelae and also due to a series of clinical complications, and if not recognized at an early stage, this disease can be refractory to antifungal therapy.

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Section: Combined Systemic Antifungal Treatmentmentioning

confidence: 99%

Section: Role Of Other Triazolesmentioning

confidence: 99%

Chromoblastomycosis

et al. 2017

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“…In refractory cases, the combination of these two drugs can be tempted 27 . Other effective treatments include posaconazole, 800 mg per day and the combination of itraconazole with 5-flucytosine 2 , 5 , 14 , 21 . The association of the latter with posaconazole may play an important role in the therapy of CBM.…”

Section: Therapymentioning

confidence: 99%

Chromoblastomycosis: A Neglected Tropical Disease

Queiroz‐Telles

2015

Rev. Inst. Med. trop. S. Paulo

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SUMMARYChromoblastomycosis (CMB) is a chronic fungal infection of the skin and the subcutaneous tissue caused by a transcutaneous traumatic inoculation of a specific group of dematiaceous fungi occurring mainly in tropical and subtropical zones worldwide. If not diagnosed at early stages, patients with CBM require long term therapy with systemic antifungals, sometimes associated with physical methods. Unlike other neglected endemic mycoses, comparative clinical trials have not been performed for this disease. Nowadays, therapy is based on a few open trials and on expert opinion. Itraconazole either as monotherapy or associated with other drugs, or with physical methods, is widely used. Recently, photodynamic therapy has been successfully employed in combination with antifungals in patients presenting with CBM. In the present revision the most used therapeutic options against CBM are reviewed as well as the several factors that may have impact on the patient's outcome.

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“…También se ha reportado el uso combinado de itraconazol con 5-flucitosina con muy buenos resultados (48,50).…”

Section: Tratamiento Esporotricosis Cromoblastomicosisunclassified

Esporotricosis y cromoblastomicosis: revisión de la literatura

Gaviria-Giraldo¹,

Cardona‐Castro²

2017

CES Med.

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ResumenLas micosis subcutáneas hacen referencia a infecciones producidas por hongos que se encuentran en la naturaleza, adquiridas por inoculación directa y limitadas a la dermis y tejido celular subcutáneo, pero pueden extenderse hacia la epidermis o hacia planos más profundos llegando a comprometer estructuras óseas, así como diseminarse y producir enfermedad sistémica. Dentro de las micosis subcutáneas más importantes en nuestro medio y de las cuales se hablarán en este artículo están la esporotricosis y la cromoblastomicosis; mientras que las menos frecuentes incluyen micetoma, quistes faeomicóticos, lacaziosis y la zigomicosis subcutánea.Palabras clave: Dermatomicosis, Esporotricosis, Cromoblastomicosis, Micosis subcutáneas. AbstractSubcutaneous mycoses, refer to infections caused by fungi which the ecologic niche is the nature, they are acquired by direct inoculation, limited to the dermis and subcutaneous tissue, but may extend into the epidermis or deeper levels reaching compromise bone structures and systemic spread and cause disease. Among the most important in our country, and which will discuss in this article, subcutaneous mycoses are sporotrichosis and chromoblastomycosis, mycetoma include less frequent, the faeomycosis, lacaziosis, and subcutaneous zygomycosis.Keywords: Dermatomycoses, Sporotrichosis, Chromoblastomycosis, Subcutaneous mycosis. IntroducciónLas infecciones micóticas incluyen un amplio grupo que van desde entidades superficiales hasta infecciones profundas asociadas a planos más profundos, que incluso llegan a comprometer estructuras óseas o diseminarse y producir enfermedad sistémica. Dentro de las micosis subcutáneas más importantes en nuestro medio están la esporotricosis y la cromoblastomicosis; las menos frecuentes son micetoma, quistes faeomicóticos, lacaziosis y zigomicosis subcutánea. Los microrganismos causantes se inoculan en la piel luego de un trauma con material vegetal contaminado con el hongo y por esto también han sido llamadas micosis de implantación (1,2).

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Treatment of severe chromoblastomycosis with itraconazole and 5-flucytosine association

Cited by 21 publications

References 16 publications

Chromoblastomycosis

Chromoblastomycosis

Chromoblastomycosis: A Neglected Tropical Disease

Esporotricosis y cromoblastomicosis: revisión de la literatura

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