Leishmaniose cutânea experimental: II - aspectos evolutivos da infecção no primata Cebus apella (Cebidae) pela Leishmania (V.) Braziliensis e L. (L.) Amazonensis

Sílveira, Fernando Tobias; Lainson, Ralph; Shaw, Jeffrey Jon; Garcez, Lourdes Maria; Souza, Álvaro Nogueira de; Braga, R. R.; Ishikawa, Edna Aoba Yassui

doi:10.1590/s0037-86821990000100002

Cited by 14 publications

(6 citation statements)

References 6 publications

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“…Previous studies showed that S. apella primates infected with the L. ( L. ) amazonensis and L. ( V. ) braziliensis parasites develop clinical and histopathological skin lesions which spontaneously self-heal and resemble human localized cutaneous lesions [8, 9, 11]. Therefore, S. apella primates represent an experimental model of the host resistance since they are able to cure the infection with the parasite elimination.…”

Section: Discussionmentioning

confidence: 99%

Dynamic of the Cellular Immune Response at the Dermal Site ofLeishmania (L.) amazonensisandLeishmania (V.) braziliensisInfection inSapajus apellaPrimate

Laurenti

Passero

Tomokane

et al. 2014

BioMed Research International

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The purpose of this study was to characterize the immunopathological response in the skin of S. apella infected with Leishmania (L.) amazonensis and L. (V.) braziliensis parasites, the main causative agents of localized cutaneous leishmaniasis in South America. In infected animals, amastigote forms of L. (L.) amazonensis could be detected till 120 days postinfection (PI), while, in L. (V.) braziliensis infection, parasites could be detected until 180 days PI in the skin sections. CD20+ cells were detected throughout the experimental time in both groups as well as in CD3+ cells, which appeared to be activated because high densities of inducible nitric oxide synthase (iNOS+) cells were detected at 60 and 90 days PI in both studied groups. After 60 and 120 days PI, decrease in iNOS+ cells was observed in L. (L.) amazonensis and L. (V.) braziliensis, respectively, which was associated with parasite clearance. Increase in lysozyme+ cells was observed during the experimental infections, which also can be associated with parasite killing.

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Section: Discussionmentioning

confidence: 99%

Dynamic of the Cellular Immune Response at the Dermal Site ofLeishmania (L.) amazonensisandLeishmania (V.) braziliensisInfection inSapajus apellaPrimate

Laurenti

Passero

Tomokane

et al. 2014

BioMed Research International

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“…Cross immunity experiments in monkeys with these different cutaneous parasites showed complex patterns of protection 42,43 . One surprising result was that the localization of the primary infection site affected subsequent clinical immunity.…”

Section: Continued Funding and Illustrious Visitorsmentioning

confidence: 99%

A partnership that worked: the Wellcome Trust and the Instituto Evandro Chagas and beyond

Shaw

2016

Revista Pan-Amazônica de Saúde

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“…The advantage of Euler hyetographs over Chicago hyetographs is a very simple designany form of IDF or DDF curves can be used. In the case of Chicago hyetographs, the IDF or DDF curve must be described by a specific equation [10].…”

Section: Introductionmentioning

confidence: 99%

A determination of the synthetic hyetograph parameters for flow capacity assessment concerning stormwater systems

Mazurkiewicz

Skotnicki

2018

E3S Web Conf.

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The paper presents the results of an analysis of the influence of synthetic rainfall duration and location of rainfall intensity peak on the rate of the flood volume in surcharged storm sewers. The analyzed rainfalls had durations from 15 minutes to 180 minutes. It was assumed, that the rainfall peak location would change between the beginning and the end of the rainfall with increments of 10% of the rainfall duration. Outflow simulations were performed with the use of SWMM5.1.012 for three models of real urban catchments with surfaces from 1.6 km 2 to 6.7 km 2 . An assessment of the influence of rainfall parameters was made on the basis of the flood volume rates. Short rainfalls with peaks located at the beginning of rainfall duration do not generate flooding. For other rainfalls it was found that for a specified rainfall duration the flood volume increases with the increase of time of the rainfall peak location. The maximum flood volume varied from 5% to 12% of the total runoff volume, depending on the catchment area, and is generated by the rainfall, whose intensity peak occurs right after the time corresponding to the flow time through the catchment.

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Leishmaniose cutânea experimental: II - aspectos evolutivos da infecção no primata Cebus apella (Cebidae) pela Leishmania (V.) Braziliensis e L. (L.) Amazonensis

Cited by 14 publications

References 6 publications

Dynamic of the Cellular Immune Response at the Dermal Site ofLeishmania (L.) amazonensisandLeishmania (V.) braziliensisInfection inSapajus apellaPrimate

Dynamic of the Cellular Immune Response at the Dermal Site ofLeishmania (L.) amazonensisandLeishmania (V.) braziliensisInfection inSapajus apellaPrimate

A partnership that worked: the Wellcome Trust and the Instituto Evandro Chagas and beyond

A determination of the synthetic hyetograph parameters for flow capacity assessment concerning stormwater systems

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