A partnership that worked: the Wellcome Trust and the Instituto Evandro Chagas and beyond

Shaw, Jeffrey Jon

doi:10.5123/s2176-62232016000500004

Cited by 4 publications

(4 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the contrary, they are not widely used for CL due to their low sensitivity and variable specificity, as cutaneous lesions often show lower levels of antibodies [ 1 , 183 ]. This could be since antibodies are partly species specific, and if a heterologous antigen is used, its detection may be low or undetectable [ 184 ]. Nonetheless, in the diagnosis of CL, Dot-Blot [ 138 ], and IFAT [ 185 ] have demonstrated high sensitivity.…”

Section: Diagnostic Tools For Leishmaniasesmentioning

confidence: 99%

One Health Approach to Leishmaniases: Understanding the Disease Dynamics through Diagnostic Tools

et al. 2020

Self Cite

View full text Add to dashboard Cite

Leishmaniases are zoonotic vector-borne diseases caused by protozoan parasites of the genus Leishmania that affect millions of people around the globe. There are various clinical manifestations, ranging from self-healing cutaneous lesions to potentially fatal visceral leishmaniasis, all of which are associated with different Leishmania species. Transmission of these parasites is complex due to the varying ecological relationships between human and/or animal reservoir hosts, parasites, and sand fly vectors. Moreover, vector-borne diseases like leishmaniases are intricately linked to environmental changes and socioeconomic risk factors, advocating the importance of the One Health approach to control these diseases. The development of an accurate, fast, and cost-effective diagnostic tool for leishmaniases is a priority, and the implementation of various control measures such as animal sentinel surveillance systems is needed to better detect, prevent, and respond to the (re-)emergence of leishmaniases.

show abstract

Section: Diagnostic Tools For Leishmaniasesmentioning

confidence: 99%

One Health Approach to Leishmaniases: Understanding the Disease Dynamics through Diagnostic Tools

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…aegypti mosquitoes [182] and An. gambiae [183], has led to the use of innovative technologies to create other products free of DEET that are marketed in the form of sprays or creams and include other active ingredients [184], such as picaridin [185] and IR 3535 [186], and a wide range of essential oils, which synergistically use various components and have been reported to provide a higher repellent activity than single isolated components [187]. Recently, a mixture of compounds isolated from Xenorhabdus budapestensis (entomopathogenic-associated bacteria) exhibited potent feeding-deterrent activity against three mosquito species considered to be the most important vectors of diseases affecting public health.…”

Section: Bacterial-based Feeding Deterrents and Repellentsmentioning

confidence: 99%

Translational Research for Zoonotic Parasites: New Findings toward Improved Diagnostics, Therapy and Prevention

2021

View full text Add to dashboard Cite

show abstract

“…During his life in Belém, Ralph hosted many friends, fellow scientists and illustrious visitors (Shaw 2016), but I felt that the very special one for him was Cyril Garnham's visit in 1969. He stayed with Ralph, and during the first days he was unwell-perhaps it was the strain of the journey combined with the humid heat.…”

Section: Back To Tropical America: Belém Pará Brazil 1965-2015mentioning

confidence: 99%

“…Compared with that, covering his 50 years in Belém is a truly daunting assignment. The focus of the following text is to expand on previously published accounts ((8); Shaw 2016, 2019), and it includes key historical events that moulded the Brazilian society and ended up affecting Ralph's daily life.…”

Section: Careermentioning

confidence: 99%

Ralph Lainson. 21 February 1927—5 May 2015

Shaw

2020

Biogr. Mems Fell. R. Soc.

Self Cite

View full text Add to dashboard Cite

Ralph Lainson was a distinguished protozoologist and a parasitologist of many abilities. Above all, he was a naturalist, as reflected both by his approach to work and by his two principal hobbies, fishing and collecting butterflies. Besides this, he had a strong artistic streak, expressed by his love of playing the trombone and painting. Many of his published works are exquisitely illustrated with his own watercolour and pen and ink drawings. These talents are present throughout his scientific career. He was a ‘traditional protozoologist’, who wanted to find out how parasites were transmitted and related to each other. Although many of the organisms he discovered were associated with a disease, Ralph openly admitted that his ultimate interest would always be the parasite. His research methods were simple, but he would readily embrace a technology if it solved his problem. He admitted to not being good with equipment. As an example, he mentioned an aptitude test used by the British Army: to put together a dismantled bicycle tyre pump—for him this was an impossible task! This shows his ability to use such tales to get others to do tasks he preferred not to, as they distracted him. His self-control was remarkable; in the 30 years that we worked together, I cannot remember a single instance of him raising his voice to anybody. He was extremely dedicated to whatever he did, be it work, hobbies or play. His stories at the dinner table or around a campfire, when out in the field, were a source of joy that reflected his good nature.

show abstract

A partnership that worked: the Wellcome Trust and the Instituto Evandro Chagas and beyond

Cited by 4 publications

References 72 publications

One Health Approach to Leishmaniases: Understanding the Disease Dynamics through Diagnostic Tools

One Health Approach to Leishmaniases: Understanding the Disease Dynamics through Diagnostic Tools

Translational Research for Zoonotic Parasites: New Findings toward Improved Diagnostics, Therapy and Prevention

Ralph Lainson. 21 February 1927—5 May 2015

Contact Info

Product

Resources

About