The association of Schistosoma mansoni infection with hepatocellular carcinoma

Abstract

The association of Schistosoma mansoni infection with hepatocellular carcinoma (HCC) was studied in Espirito Santo State, Brazil. Schistosoma infection was diagnosed by stool examinations or by histological finding at autopsy. HCC was diagnosed by biopsy, laparoscopy and biopsy or at autopsy. Among 45 cases of HCC six had Schistosoma mansoni infection (13.04%). The occurrence of Schistosoma infection among HCC HBs Ag positive or negative was similar (13.3 3% and 13.63% respectively). The chi squared comparison showed no significant differences between the frequency of schistosomiasis in patients with HCC and the frequency of Schistosoma infection among people living in the Espirito Santo State (5.9% among children of elementary school from all the counties of the State and 6.7% in people that attended medical care in Vitoria, the capital of the State). Therefore, the authors believe that the association of schistosomiasis mansoni with HCC may be casual, specially in areas where the Schistosoma mansoni infection is frequent.

Metástase orbital como primeira manifestação clínica de hepatocarcinoma

“…Nossa paciente apresentava sorologia negativa para hepatites B e C. No que diz respeito à doença hepá-tica, a paciente tinha diagnóstico de hipertensão portal esquistossomótica. Apesar de já ter sido citada a associação entre esquistossomose mansônica e hepatocarcinoma (27) , não existe adequada evidência do potencial carcinogênico desta doença em humanos (28,29) . Os pacientes com metástase orbital secundária a hepatocarcinoma apresentam como manifestações típi-cas dor, proptose e perda visual (4,26) .…”