Comentários sôbre caso de transmissão da doença de chagas por transfusão de sangue e longo período de incubação

Amato, Vicente; Dias, Anderson Fernandes

doi:10.1590/s0037-86821969000500008

Cited by 7 publications

(2 citation statements)

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“…In addition, outside the transplant setting, CDR has been described as single case reports in 12 patients from 1968 to 2015 ( Table 5 ), more frequently in non-Hodgkin lymphoma and Hodgkin lymphoma 37 - 48 . Reactivation occurred during the induction phase or chemotherapy in the majority.…”

Section: Resultsmentioning

confidence: 99%

Multiple myeloma and Chagas disease: qPCR as a marker for preemptive antiparasitic therapy: a case reports series and review

Carvalho,

Freitas,

Seguro

et al. 2024

Rev. Inst. Med. trop. S. Paulo

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Multiple myeloma (MM) associated with Chagas disease is rarely described. This disease and its therapy suppress T cell and macrophage functions and increase regulatory T cell function, allowing the increase of parasitemia and the risk of Chagas Disease Reactivation (CDR). We aimed to analyze the role of conventional (cPCR) and quantitative Polymerase Chain Reaction (qPCR) for prospective monitoring of T. cruzi parasitemia, searching for markers of preemptive antiparasitic therapy in MM patients with Chagas disease. Moreover, we investigated the incidence and management of hematological diseases and CDR both inside and outside the transplant setting in the MEDLINE database. We found 293 studies and included 31 of them. Around 1.9–2.0% of patients with Chagas disease were reported in patients undergoing Stem Cell Transplantation. One case of CDR was described in eight cases of MM and Chagas disease . We monitored nine MM and Chagas disease patients, seven under Autologous Stem Cell Transplantation (ASCT), during 44.56±32.10 months (mean±SD) using parasitological methods, cPCR, and qPCR. From these patients, three had parasitemia. In the first, up to 256 par Eq/mL were detected, starting from 28 months after ASCT. The second patient dropped out and died soon after the detection of 161.0 par Eq/mL. The third patient had a positive blood culture. Benznidazole induced fast negativity in two cases; followed by notably lower levels in one of them. Increased T. cruzi parasitemia was related to the severity of the underlying disease. We recommend parasitemia monitoring by qPCR for early introduction of preemptive antiparasitic therapy to avoid CDR.

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Section: Resultsmentioning

confidence: 99%

Multiple myeloma and Chagas disease: qPCR as a marker for preemptive antiparasitic therapy: a case reports series and review

Carvalho,

Freitas,

Seguro

et al. 2024

Rev. Inst. Med. trop. S. Paulo

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show abstract

“…O período de incubação varia de 20 a 40 dias -um pouco mais prolongado do que o observado por transmissão vetorial -embora períodos bem mais curtos (8 dias) ou longos (120 dias) (AMATO NETO et al, 1969) tenham sido descritos.…”

Section: Doença De Chagas Transfusional: Quadro Clínicounclassified

Clínica e terapêutica da doença de Chagas: uma abordagem prática para o clínico geral

Dias¹,

Coura²

1997

103

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Diagnosis of Trypanosoma cruzi Infection

Luquetti

Schmuñis

2010

American Trypanosomiasis

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Comentários sôbre caso de transmissão da doença de chagas por transfusão de sangue e longo período de incubação

Cited by 7 publications

References 0 publications

Multiple myeloma and Chagas disease: qPCR as a marker for preemptive antiparasitic therapy: a case reports series and review

Multiple myeloma and Chagas disease: qPCR as a marker for preemptive antiparasitic therapy: a case reports series and review

Clínica e terapêutica da doença de Chagas: uma abordagem prática para o clínico geral

Diagnosis of Trypanosoma cruzi Infection

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