Seroprevalence of Chagasic Infection in Young Individuals in a Blood Center in the State of Sao Paulo, Brazil

Abstract

SUMMARYThis study aimed at estimating the number of cases of non-negative serological reactions to Chagas disease in blood donors at the Blood Center of Botucatu, São Paulo, Brazil, from 2003 to 2010 and at relating them to their cities of origin. Five hundred and seventy-four non-negative results for Chagas disease were evaluated. Of these, 371 (64.8%) were reagent, and 203 (35.4%) were inconclusive. The prevalence of Chagas disease in blood donors was 0.05%. There were, on average, 72 cases/year, and a prevalence of males was observed (64.8%). Forty-three (7.49%) individuals were 18 to 30 years old; 92 (16.02%) were 31 to 40; 147 (25.61%) 41 to 50, and 292 (50.87%) were older than 50 years. It was observed that 29.3% of females with reagent serology were at their fertile age (18 and 45 years). The majority of donors were originally from cities in the southwestern and central regions of São Paulo, but individuals from other states contributed with 20%. The provenance of most donors was the city of Botucatu/SP, followed by the city of Taquarituba/SP. Therefore, the profile of donors at this blood center favors the occurrence of a larger number of non-negative serological reactions. Although there has been a significant reduction in the number of new cases/year for this disease, it is still a public-health problem, and results suggest the need for new epidemiological assessments in the studied region.

Prevalência da Infecção pelo Trypanosoma cruzi em Doadores de Sangue

“…Embora outros estudos também mostrem essa predominância do sexo masculino nos indivíduos portadores da DC, não existe uma correlação positiva entre o sexo do doador e a sorologia reagente para a doença, pois ela afeta indistintamente homens e mulheres, mas pode ser justificada pelo fato que muitos homens trabalhavam em áreas rurais, tendo mais chances de entrar em contato com o triatomíneo, como também devido a diferenças culturais na prática da doação de sangue que comumente atribui aos homens o papel de doador por excelência. 28,[32][33][34] Quanto à naturalidade, sabe-se que muitos indivíduos sabidamente infectados moram ou moraram em regiões interioranas, que constituem os ecótopos naturais do inseto vetor e, posteriormente, muitos acabam migrando para os grandes centros urbanos como Fortaleza fugindo da seca e em busca de emprego e oportunidades. 35 Apesar do certificado de erradicação da doença de Chagas por Triatoma infestans é importante deixar claro que essa espécie nunca foi encontrada no estado do Ceará, portanto o risco de transmissão da DC no Ceará é devido as espécies de triatomíneos mais prevalentes o Triatoma brasiliensis e o Triatoma pseudomaculata.…”

Impact of Chagas Disease on Human Evolution: The Challenges Continue

“…The main inconvenient of these tests would be the occurrence of cross reaction (false positive), but the kits used have been presenting a growing efficiency. The authors of this study performed, at the Blood center of Botucatu (FMB/ UNESP), a lifting of non-negative serological reactions for Chagas Disease (positive and inconclusive) between the years 2003 and 2010 and the average of inconclusive negative reactions was below 35% (Navarro et al, 2013a). Another study made in the same work evaluated the inconclusive serological reactions through different methods (ELISA, HAI, IFI and immunoblotting TESA-cruzi) and concluded that TESA-cruzi is the best method to confirm the positive serology of individuals that present over two inconclusive reactions (Picka et al, 2007).…”

“…In study performed by Navarro et al (2013a) at the Hemocenter of Botucatu, town inside of the State of São Paulo, the prevalence of no negative reactions (positives and inconclusive) was of 0.5%, which is the biggest national average (0.2%)- (MoraesSouza & Ferreira-Silva, 2011).…”

Hallazgos clínicos, ecocardiográficos y electrocardiográficos en donantes de sangre seropositivos para Trypanosoma cruzi en un centro de referencia del sur de Colombia

“…Diversos estudios han documentado de manera clara las anormalidades electrocardiográficas en pacientes en la fase indeterminada, en pacientes con serologías positivas en bancos de sangre por diversos métodos. Además, han evaluado la evolución ecocardiográfica y progresión a enfermedad cardiaca sintomática, como también la respuesta al tratamiento en la fase indeterminada, evidenciando un efecto positivo del mismo en los distintos reportes [11][12][13][14][15][16][17][18] . El objeto del presente estudio fue evaluar las características clínicas y hallazgos electrocardiográficos como de ecocardiografía en pacientes quienes tenían una serología positiva en el banco de datos de un centro de referencia del sur de Colombia.…”