Impact of Chagas Disease on Human Evolution: The Challenges Continue

Navarro, Elaine Cristina; Pereira, Paulo Câmara Marques

doi:10.4236/aa.2013.34a001

Cited by 2 publications

(3 citation statements)

References 36 publications

(33 reference statements)

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“…Also, information, education, and communication programs on CD still need to be strengthened at the community level (134). Thus, although public health authorities worldwide and in Latin America have made efforts to control the several forms of transmission of CD, there are still many challenges for the elimination of parasites in humans and domestic and wild reservoirs (134, 137).…”

Section: Future Implicationsmentioning

confidence: 99%

“…Additionally, necropsies of 92 elderly CD patients revealed SAH (37%), atherosclerosis (62%) and ischemic heart disease (6.5%) (148), indicating an overlap between these comorbidities and CD. Navarro and collaborators (137) reported 75.7% of dyslipidemia in patients with indeterminate form, suggesting an increased risk of progression to the symptomatic form of CD. Since one of the leading causes of mortality in patients with chronic CD is sudden death, these findings indicate that dyslipidemia and/or atherosclerosis may have a direct influence on patient survival (149).…”

Section: Future Implicationsmentioning

confidence: 99%

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Chagas Disease: From Discovery to a Worldwide Health Problem

Lidani

Andrade

Bavia

et al. 2019

Front. Public Health

406

329

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Carlos Chagas discovered American trypanosomiasis, also named Chagas disease (CD) in his honor, just over a century ago. He described the clinical aspects of the disease, characterized by its etiological agent ( Trypanosoma cruzi ) and identified its insect vector. Initially, CD occurred only in Latin America and was considered a silent and poorly visible disease. More recently, CD became a neglected worldwide disease with a high morbimortality rate and substantial social impact, emerging as a significant public health threat. In this context, it is crucial to better understand better the epidemiological scenarios of CD and its transmission dynamics, involving people infected and at risk of infection, diversity of the parasite, vector species, and T. cruzi reservoirs. Although efforts have been made by endemic and non-endemic countries to control, treat, and interrupt disease transmission, the cure or complete eradication of CD are still topics of great concern and require global attention. Considering the current scenario of CD, also affecting non-endemic places such as Canada, USA, Europe, Australia, and Japan, in this review we aim to describe the spread of CD cases worldwide since its discovery until it has become a global public health concern.

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Section: Future Implicationsmentioning

confidence: 99%

Section: Future Implicationsmentioning

confidence: 99%

Chagas Disease: From Discovery to a Worldwide Health Problem

Lidani

Andrade

Bavia

et al. 2019

Front. Public Health

406

329

View full text Add to dashboard Cite

show abstract

“…Chagas disease (CD) is a neglected tropical disease caused by the protozoan Trypanosoma cruzi which leads to higher rates of morbidity and mortality in Latin America than any other parasitic disease, resulting in significant decreases in the quality of life due to disability 1 . Although most infected individuals remain asymptomatic for their entire lives, about 20-30% develop chronic Chagas cardiomyopathy (CCC) 2 , 3 .…”

Section: Introductionmentioning

confidence: 99%

Clinical and epidemiological aspects of chronic Chagas disease from Southern Brazil

Lidani

Sandri

Castillo-Neyra

et al. 2020

Rev. Soc. Bras. Med. Trop.

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Introduction: Patients with Chagas disease (CD), caused by Trypanosoma cruzi, present a higher risk of developing other chronic diseases, which may contribute to CD severity. Since CD is underreported in the southern state of Paraná, Brazil, we aimed to characterize clinical and epidemiological aspects of individuals chronically infected with T. cruzi in Southern Brazil. Methods: A community hospital-based study was performed, recording clinical/demographic characteristics of 237 patients with CD from Southern Brazil. To estimate the association between different forms of CD and sociodemographic and clinical variables, multiple logistic regression models were built using the Akaike information criterion. Results: Mean age was 57.5 years and 59% were females. Most patients' (60%) place of origin/birth was within Paraná and they were admitted to the CD outpatient clinic after presenting with cardiac/digestive symptoms (64%). The predominant form of CD was cardiac (53%), followed by indeterminate (36%), and digestive (11%). The main electrocardiographic changes were in the right bundle branch block (39%) and left anterior fascicular block (32%). The average number of comorbidities per patient was 3.9±2.3; systemic arterial hypertension was most common (64%), followed by dyslipidemia (34%) and diabetes (19%); overlapping comorbidities were counted separately. Male sex was associated with symptomatic cardiac CD (OR=2.92; 95%CI: 1.05-8.12; p=0.040). Conclusions: This study provided greater understanding of the distribution and clinical profile of CD patients in Southern Brazil, indicating a high prevalence of comorbidities among these patients who are a vulnerable group due to advanced age and substantial risk of morbidity.

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Impact of Chagas Disease on Human Evolution: The Challenges Continue

Cited by 2 publications

References 36 publications

Chagas Disease: From Discovery to a Worldwide Health Problem

Chagas Disease: From Discovery to a Worldwide Health Problem

Clinical and epidemiological aspects of chronic Chagas disease from Southern Brazil

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