Disseminated toxoplasmosis presenting as sepsis in two AIDS patients

Abstract

SUMMARYThis report describes two patients who presented acute disseminated and severe toxoplasmosis as the first opportunistic disease related to acquired immunodeficiency syndrome. At admission, clinical and laboratory findings were similar to sepsis or septic shock and a fast evolutive course to death occurred in both cases. At necropsy, an inflammatory reaction and presence of a great number of Toxoplasma gondii cysts and tachyzoites were observed in most organs examined.

Seroprevalence and Sources of Toxoplasmosis among Orang Asli (Indigenous) Communities in Peninsular Malaysia

“…Significantly, toxoplasmosis may cause serious complications in fetuses of infected pregnant mothers 2 and in immunocompromised patients who have undergone solid organ transplants 3 or have human immunodeficiency virus (HIV)/AIDS. 4 In Malaysia, the prevalence rate of toxoplasmosis in the general population was reported to be at 28.1% in 2002. 5 Seroprevalence of toxoplasmosis among HIV/AIDS patients was higher, with rates recorded at 51.2% ( N = 406) 6 and 44.8% ( N = 505).…”

Anti-Toxoplasma gondii activity of GAS in vitro

“…In individuals with AIDS and other immunosuppressive disorders, Toxoplasma gondii may cause serious complications, such as necrotizing encephalitis, pneumonitis and myocarditis (Barbosa et al, 2007;Carruthers and Suzuki, 2007;Novoselov et al, 2007), even death (Castilho-Pelloso et al, 2007;Yuan et al, 2007). Toxoplasma gondii can also cause miscarriage in infected pregnant women, or congenital toxoplasmosis (Kravetz and Federman, 2002).…”

Prevalence of Zoonotic and Other Intestinal Protozoan Parasites in Stray Cats (Felis domesticus) of Kerman, South-East of Iran

“…T. gondii is a protozoan capable of infecting a large number of animals and has felines as its definitive host. This parasite represents a great risk to the human population, causing diverse infection and mortality levels, especially among immunosuppressed people and pregnant women (Barbosa et al, 2007).…”